SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 8 ALA A 136
LEU A  11
LEU A  20
ALA A  19
 None
 0.80A 1e7cA-3b1fA:
undetectable		 1e7cA-3b1fA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 7 HIS A  26
LEU A 166
SER A 167
ASP A 164
 None
 1.17A 1ismB-3b1fA:
3.0		 1ismB-3b1fA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 7 LEU A  83
ILE A  82
PHE A  79
ALA A  61
 None
 0.93A 1oniB-3b1fA:
undetectable
1oniC-3b1fA:
undetectable		 1oniB-3b1fA:
20.00
1oniC-3b1fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 5 PRO A  72
GLY A  10
ASN A  35
GLY A  12
 NAD  A1001 (-3.8A)
NAD  A1001 ( 3.8A)
NAD  A1001 (-3.1A)
NAD  A1001 (-3.4A)
 1.16A 1zlqA-3b1fA:
undetectable		 1zlqA-3b1fA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 11 GLY A 121
SER A 122
LEU A 162
ILE A  80
ALA A 108
 None
 1.37A 2a58A-3b1fA:
4.0
2a58E-3b1fA:
4.0		 2a58A-3b1fA:
18.21
2a58E-3b1fA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 11 ILE A  80
ALA A 108
GLY A 121
SER A 122
LEU A 162
 None
 1.38A 2a58C-3b1fA:
3.9
2a58D-3b1fA:
4.0		 2a58C-3b1fA:
18.21
2a58D-3b1fA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 12 PHE A  79
ILE A  22
LEU A 166
GLY A  15
ILE A   8
 None
 1.11A 2e7fA-3b1fA:
undetectable		 2e7fA-3b1fA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 12 PHE A  79
ILE A  22
LEU A 166
GLY A  15
ILE A   8
 None
 1.13A 2e7fB-3b1fA:
undetectable		 2e7fB-3b1fA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 5 ARG A 222
MET A 224
THR A 225
LEU A 199
 None
 1.41A 2eimJ-3b1fA:
undetectable		 2eimJ-3b1fA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 5 ARG A 222
MET A 224
THR A 225
LEU A 199
 None
 1.43A 2eimW-3b1fA:
undetectable		 2eimW-3b1fA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 12 LEU A 112
LYS A 115
ILE A  94
ILE A  67
ALA A  64
 None
 1.27A 2gj5A-3b1fA:
undetectable		 2gj5A-3b1fA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 12 PHE A  79
ILE A  22
LEU A 166
GLY A  15
ILE A   8
 None
 1.11A 2ogyA-3b1fA:
undetectable		 2ogyA-3b1fA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 12 PHE A  79
ILE A  22
LEU A 166
GLY A  15
ILE A   8
 None
 1.17A 2ogyB-3b1fA:
3.0		 2ogyB-3b1fA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 12 PHE A  79
ILE A  22
LEU A 166
GLY A  15
ILE A   8
 None
 1.14A 2ycjA-3b1fA:
2.7		 2ycjA-3b1fA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 5 ARG A 222
MET A 224
THR A 225
LEU A 199
 None
 1.39A 3ag1J-3b1fA:
undetectable		 3ag1J-3b1fA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 12 VAL A  32
ALA A  44
LEU A  20
LEU A  11
ALA A 133
 None
 1.00A 3fc6C-3b1fA:
undetectable		 3fc6C-3b1fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 12 ILE A 104
ASN A 242
VAL A 246
ILE A 194
ILE A  73
 None
None
None
None
NAD  A1001 (-4.8A)
 1.17A 3ohtA-3b1fA:
undetectable
3ohtB-3b1fA:
undetectable		 3ohtA-3b1fA:
21.34
3ohtB-3b1fA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		3 / 3 ARG A 256
PRO A 192
PHE A 253
 None
 0.87A 3thrC-3b1fA:
5.8		 3thrC-3b1fA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 12 ILE A 250
ILE A 238
ILE A 194
ASP A 248
ALA A 245
 None
 1.29A 3uj7A-3b1fA:
4.9		 3uj7A-3b1fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 10 ALA A  53
THR A  54
ALA A  55
VAL A  50
GLY A  10
 None
None
None
None
NAD  A1001 ( 3.8A)
 0.97A 4qvyK-3b1fA:
undetectable
4qvyL-3b1fA:
undetectable		 4qvyK-3b1fA:
22.22
4qvyL-3b1fA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 10 ALA A  53
THR A  54
ALA A  55
VAL A  50
GLY A  10
 None
None
None
None
NAD  A1001 ( 3.8A)
 0.97A 4qvyY-3b1fA:
undetectable
4qvyZ-3b1fA:
undetectable		 4qvyY-3b1fA:
22.22
4qvyZ-3b1fA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 5 LEU A 166
TYR A 146
ALA A  97
ILE A  14
 None
None
NAD  A1001 (-4.7A)
NAD  A1001 (-4.0A)
 0.86A 4y03B-3b1fA:
undetectable		 4y03B-3b1fA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 11 LEU A 162
VAL A  66
ILE A  67
ALA A 108
ILE A  80
 None
 0.96A 5d75A-3b1fA:
undetectable		 5d75A-3b1fA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 11 LEU A 162
VAL A  66
ILE A  67
ALA A 108
ILE A  80
 None
 0.95A 5gpgA-3b1fA:
undetectable		 5gpgA-3b1fA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 7 LEU A 140
ALA A 135
ILE A  49
LEU A  20
 None
 0.96A 5te8C-3b1fA:
undetectable		 5te8C-3b1fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		5 / 12 ILE A  68
ALA A   9
ALA A  44
ILE A  43
GLY A 132
 None
None
None
None
NAD  A1001 (-3.5A)
 1.01A 5veuB-3b1fA:
undetectable		 5veuB-3b1fA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 5 ARG A 222
MET A 224
THR A 225
LEU A 199
 None
 1.36A 5w97J-3b1fA:
undetectable		 5w97J-3b1fA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 5 ARG A 222
MET A 224
THR A 225
LEU A 199
 None
 1.29A 5z86J-3b1fA:
undetectable		 5z86J-3b1fA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		3 / 3 ALA A  62
VAL A  32
TYR A   7
 None
 0.66A 5zmqH-3b1fA:
undetectable		 5zmqH-3b1fA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 7 LEU A  86
ALA A  62
ALA A  61
THR A  54
 None
 0.70A 6a7jA-3b1fA:
undetectable		 6a7jA-3b1fA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 7 VAL A 105
ILE A  80
GLY A  12
ALA A  97
 None
None
NAD  A1001 (-3.4A)
NAD  A1001 (-4.7A)
 0.84A 6hd6B-3b1fA:
undetectable		 6hd6B-3b1fA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b1f PUTATIVE PREPHENATE
DEHYDROGENASE
(Streptococcus
mutans) 		4 / 5 ARG A 222
MET A 224
THR A 225
LEU A 199
 None
 1.22A 6nknW-3b1fA:
undetectable		 6nknW-3b1fA:
11.50