SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		3 / 3 LYS A 310
ASP A 300
ASP A 345
 None
 1.06A 2br4A-3b3jA:
5.2		 2br4A-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		4 / 8 PHE A 344
ALA A 389
LEU A 349
ASP A 393
 None
 0.96A 2bxkA-3b3jA:
undetectable		 2bxkA-3b3jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 9 LEU A 295
LEU A 388
ILE A 453
PHE A 375
ILE A 373
 None
 1.08A 2f78A-3b3jA:
undetectable		 2f78A-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 9 LEU A 295
LEU A 388
ILE A 453
PHE A 375
ILE A 373
 None
 1.11A 2f78B-3b3jA:
undetectable		 2f78B-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 9 LEU A 295
LEU A 388
ILE A 453
PHE A 375
ILE A 373
 None
 1.09A 2f7aA-3b3jA:
undetectable		 2f7aA-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 9 LEU A 295
LEU A 388
ILE A 453
PHE A 375
ILE A 373
 None
 1.03A 2f7aB-3b3jA:
undetectable		 2f7aB-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 10 LEU A 295
LEU A 388
ILE A 453
PHE A 375
ILE A 373
 None
 1.08A 2f8dA-3b3jA:
undetectable		 2f8dA-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 10 LEU A 295
LEU A 388
ILE A 453
PHE A 375
ILE A 373
 None
 1.06A 2f8dB-3b3jA:
undetectable		 2f8dB-3b3jA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		4 / 7 ALA A 176
ASN A 180
PHE A 184
LEU A 405
 None
 0.98A 2hzqA-3b3jA:
undetectable		 2hzqA-3b3jA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		4 / 7 ARG A 235
ASP A 234
ILE A 211
PHE A 201
 None
 1.06A 2jc9A-3b3jA:
2.9		 2jc9A-3b3jA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		4 / 7 PRO A 297
LEU A 435
ALA A 429
PHE A 428
 None
 0.99A 2vcvL-3b3jA:
undetectable		 2vcvL-3b3jA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		4 / 6 ASP A 393
TYR A 356
PHE A 390
LEU A 441
 None
 0.92A 2w98A-3b3jA:
8.0
2w98B-3b3jA:
8.1		 2w98A-3b3jA:
19.76
2w98B-3b3jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 12 PRO A 339
LEU A 470
ILE A 451
GLN A 418
ALA A 389
 None
 1.16A 4a83A-3b3jA:
undetectable		 4a83A-3b3jA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 11 SER A 217
GLY A 241
VAL A 214
GLU A 215
VAL A 246
 None
 1.22A 4d9hA-3b3jA:
undetectable		 4d9hA-3b3jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 11 SER A 217
GLY A 241
VAL A 214
GLU A 215
VAL A 246
 None
 1.17A 4danA-3b3jA:
undetectable		 4danA-3b3jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 12 SER A 217
GLY A 241
VAL A 214
GLU A 215
VAL A 246
 None
 1.28A 4danA-3b3jA:
undetectable
4danB-3b3jA:
undetectable		 4danA-3b3jA:
20.38
4danB-3b3jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		4 / 6 ILE A 373
PRO A 374
PHE A 375
PHE A 377
 None
 0.86A 4fgkA-3b3jA:
undetectable		 4fgkA-3b3jA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		3 / 3 LYS A 281
PRO A 282
SER A 283
 None
 0.31A 4k50I-3b3jA:
undetectable		 4k50I-3b3jA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 10 PHE A 360
VAL A 293
ASP A 292
TYR A 356
GLY A 291
 BEN  A6001 (-4.8A)
BEN  A6001 ( 4.8A)
None
None
BEN  A6001 (-3.5A)
 1.22A 4xp1A-3b3jA:
undetectable		 4xp1A-3b3jA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 12 PHE A 336
PHE A 423
LEU A 435
THR A 460
GLY A 461
 None
 1.16A 4zjlA-3b3jA:
undetectable		 4zjlA-3b3jA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 12 GLY A 195
LEU A 270
ILE A 371
PHE A 360
GLY A 291
 None
None
None
BEN  A6001 (-4.8A)
BEN  A6001 (-3.5A)
 0.98A 5eskA-3b3jA:
undetectable		 5eskA-3b3jA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3b3j HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		4 / 5 PRO A 374
LEU A 467
TYR A 449
PHE A 265
 None
BEN  A1001 (-4.5A)
BEN  A6001 ( 4.1A)
BEN  A4001 ( 4.0A)
 1.49A 5igjA-3b3jA:
1.0		 5igjA-3b3jA:
20.33