SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 267
ALA A 372
THR A 376
LEU A 413
TYR A 418
 None
 1.25A 1cbrA-3b40A:
undetectable		 1cbrA-3b40A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 267
ALA A 372
THR A 376
LEU A 413
TYR A 418
 None
 1.25A 1cbrB-3b40A:
undetectable		 1cbrB-3b40A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 165
ALA A 147
LEU A 432
PHE A 153
 None
 1.18A 1q97B-3b40A:
undetectable		 1q97B-3b40A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 346
GLU A 344
ALA A 351
PRO A 111
 None
 0.94A 2ejfA-3b40A:
undetectable		 2ejfA-3b40A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		6 / 12 ARG A 129
GLY A  79
ASP A 402
GLY A 396
GLY A 395
ILE A  60
 None
 1.26A 2fxeA-3b40A:
undetectable		 2fxeA-3b40A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 130
GLY A 135
THR A 134
ASP A 139
 None
 1.05A 2g70A-3b40A:
undetectable		 2g70A-3b40A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 267
SER A 266
ALA A 263
ALA A 372
GLY A 297
 None
 1.15A 2igtA-3b40A:
undetectable		 2igtA-3b40A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 267
SER A 266
ALA A 263
ALA A 372
GLY A 297
 None
 1.14A 2igtB-3b40A:
undetectable		 2igtB-3b40A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 PRO A  63
ILE A  60
PRO A  78
GLY A  79
 None
 1.00A 2y7kA-3b40A:
undetectable		 2y7kA-3b40A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 282
ASP A 280
TYR A 375
 None
 0.88A 2yvlB-3b40A:
undetectable		 2yvlB-3b40A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 334
GLU A 349
TYR A 350
 None
MG  A 449 (-2.2A)
None
 0.74A 2zmbA-3b40A:
undetectable		 2zmbA-3b40A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 261
SER A 266
GLY A 193
LEU A 233
ASN A 234
 None
 1.17A 2zw9A-3b40A:
undetectable		 2zw9A-3b40A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 230
ILE A 240
ILE A 261
SER A 289
 None
 0.85A 3deuA-3b40A:
undetectable		 3deuA-3b40A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 SER A 257
VAL A 262
SER A 289
GLY A 290
GLY A 291
 None
 0.98A 3ixlA-3b40A:
undetectable		 3ixlA-3b40A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 297
GLY A 396
ALA A 267
LEU A 366
LEU A 302
 None
 1.03A 3mteB-3b40A:
undetectable		 3mteB-3b40A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 266
ASP A 241
LEU A 169
ASP A 390
 None
 1.17A 3n2oC-3b40A:
5.8
3n2oD-3b40A:
7.0		 3n2oC-3b40A:
21.46
3n2oD-3b40A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 297
GLY A 396
ALA A 267
LEU A 366
LEU A 302
 None
 1.03A 3p2kA-3b40A:
undetectable		 3p2kA-3b40A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 297
GLY A 396
ALA A 267
LEU A 366
LEU A 302
 None
 1.02A 3p2kB-3b40A:
undetectable		 3p2kB-3b40A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 297
GLY A 396
ALA A 267
LEU A 366
LEU A 302
 None
 1.06A 3p2kD-3b40A:
undetectable		 3p2kD-3b40A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 277
ALA A 267
ARG A 303
ALA A 300
 None
 1.15A 3twpA-3b40A:
undetectable		 3twpA-3b40A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 236
LEU A 233
LEU A 178
SER A 179
 None
 0.96A 3vhuA-3b40A:
undetectable		 3vhuA-3b40A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		6 / 11 ILE A 261
ASP A 241
ILE A 240
GLY A 193
PHE A 194
GLY A 226
 None
 1.18A 4ac9B-3b40A:
2.5
4ac9C-3b40A:
2.2		 4ac9B-3b40A:
23.35
4ac9C-3b40A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 396
ASP A 390
GLY A 394
VAL A 296
 None
 0.93A 4c5nA-3b40A:
4.2		 4c5nA-3b40A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 396
GLY A 399
TYR A  38
GLU A 405
 None
 0.93A 4fgzA-3b40A:
undetectable		 4fgzA-3b40A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 396
GLY A 399
TYR A  38
GLU A 405
 None
 0.92A 4fgzB-3b40A:
undetectable		 4fgzB-3b40A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 263
LEU A 250
SER A 246
SER A 257
LEU A 222
 None
 1.07A 4ky8C-3b40A:
undetectable		 4ky8C-3b40A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 263
LEU A 250
SER A 246
SER A 257
LEU A 222
 None
 1.10A 4ky8D-3b40A:
undetectable		 4ky8D-3b40A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 262
ASP A 241
SER A 388
ALA A  97
 None
 1.13A 4nedA-3b40A:
undetectable		 4nedA-3b40A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  97
GLN A 294
GLY A 386
 None
 0.60A 4odoC-3b40A:
undetectable		 4odoC-3b40A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 263
LEU A 250
SER A 246
SER A 257
LEU A 222
 None
 1.12A 4q0dC-3b40A:
undetectable		 4q0dC-3b40A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 263
LEU A 250
SER A 246
SER A 257
LEU A 222
 None
 1.12A 4q0dD-3b40A:
undetectable		 4q0dD-3b40A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 405
ASP A 402
LEU A  81
GLU A  47
GLY A  87
 None
 1.27A 4xe5A-3b40A:
undetectable		 4xe5A-3b40A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 386
ASP A 422
TYR A 418
HIS A  50
ILE A  53
 None
 1.35A 4ypeA-3b40A:
undetectable		 4ypeA-3b40A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 221
ASP A 204
ALA A 203
PHE A 194
VAL A 253
 None
 1.37A 5c8tB-3b40A:
undetectable		 5c8tB-3b40A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 TYR A 375
ASP A 280
VAL A 385
ILE A 293
LEU A 278
 None
 1.33A 5hw8C-3b40A:
undetectable
5hw8H-3b40A:
undetectable		 5hw8C-3b40A:
15.78
5hw8H-3b40A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 THR A  61
SER A 389
SER A 388
SER A 243
 None
 1.10A 5l5fY-3b40A:
undetectable
5l5fZ-3b40A:
undetectable		 5l5fY-3b40A:
19.22
5l5fZ-3b40A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 369
GLY A 297
SER A 389
SER A 388
 None
 1.37A 5uunA-3b40A:
undetectable		 5uunA-3b40A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3b40 PROBABLE DIPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 233
ASN A 200
LEU A 222
 None
 0.77A 6exiD-3b40A:
undetectable		 6exiD-3b40A:
13.00