SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 3b43 TITIN
(Oryctolagus
cuniculus) 		5 / 10 VAL A 253
GLY A 238
LEU A 254
TYR A 264
ILE A 234
 None
 1.45A 1sq5D-3b43A:
undetectable		 1sq5D-3b43A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 7 ILE A 234
LYS A 214
PHE A 213
GLY A 211
 None
 1.14A 3sj0X-3b43A:
undetectable		 3sj0X-3b43A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 6 LEU A 205
VAL A 203
PHE A 213
VAL A 253
 None
 1.16A 3soaA-3b43A:
undetectable		 3soaA-3b43A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 6 LEU A 345
MET A 347
THR A 305
ARG A 297
 None
 1.12A 3thrB-3b43A:
undetectable		 3thrB-3b43A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 3b43 TITIN
(Oryctolagus
cuniculus) 		3 / 3 SER A 278
PHE A 196
LYS A 199
 None
 0.99A 3u88A-3b43A:
undetectable		 3u88A-3b43A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 6 VAL A 129
TRP A 131
PHE A 100
GLU A 118
 None
 1.40A 3ufrA-3b43A:
undetectable
3ufrB-3b43A:
undetectable		 3ufrA-3b43A:
21.12
3ufrB-3b43A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3b43 TITIN
(Oryctolagus
cuniculus) 		3 / 3 ASP A 417
GLU A 450
GLY A 449
 None
 0.49A 3w9tA-3b43A:
undetectable		 3w9tA-3b43A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 8 GLU A 361
ASN A 364
GLY A 367
SER A 368
 None
 0.90A 4f93B-3b43A:
4.2		 4f93B-3b43A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 8 GLY A 499
ALA A 553
LYS A 471
GLU A 552
 None
 0.85A 4hyfB-3b43A:
undetectable		 4hyfB-3b43A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 7 LYS A 214
THR A 248
THR A 243
VAL A 245
 None
 0.78A 4ik7A-3b43A:
undetectable		 4ik7A-3b43A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3b43 TITIN
(Oryctolagus
cuniculus) 		5 / 12 LEU A 375
LEU A 293
LEU A 345
MET A 336
ILE A 328
 None
 1.11A 4o2bB-3b43A:
undetectable		 4o2bB-3b43A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 4 ASN A 541
SER A 535
ALA A 537
VAL A 487
 None
 1.06A 4x1kC-3b43A:
undetectable		 4x1kC-3b43A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 7 THR A 250
LEU A 251
LEU A 254
THR A 212
 None
 0.96A 4z91F-3b43A:
undetectable
4z91G-3b43A:
undetectable
4z91H-3b43A:
undetectable
4z91I-3b43A:
undetectable
4z91J-3b43A:
undetectable		 4z91F-3b43A:
19.61
4z91G-3b43A:
19.61
4z91H-3b43A:
19.61
4z91I-3b43A:
19.61
4z91J-3b43A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 4 ASN A 541
SER A 535
ALA A 537
VAL A 487
 None
 1.22A 5nm5A-3b43A:
undetectable		 5nm5A-3b43A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3b43 TITIN
(Oryctolagus
cuniculus) 		4 / 7 GLU A 340
SER A 341
VAL A 339
ARG A 306
 None
 1.36A 6av6C-3b43A:
undetectable
6av6D-3b43A:
undetectable		 6av6C-3b43A:
11.89
6av6D-3b43A:
11.89