SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3b49 LIN2189 PROTEIN
(Listeria
innocua) 		3 / 3 ASP A  97
ASP A  42
ASP A  92
 None
 0.72A 2igtA-3b49A:
undetectable		 2igtA-3b49A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3b49 LIN2189 PROTEIN
(Listeria
innocua) 		3 / 3 ASP A  97
ASP A  42
ASP A  92
 None
 0.74A 2igtB-3b49A:
undetectable		 2igtB-3b49A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3b49 LIN2189 PROTEIN
(Listeria
innocua) 		5 / 11 ILE A 186
GLY A  83
PHE A  32
PRO A  80
ILE A 104
 None
 1.24A 2y7kA-3b49A:
undetectable		 2y7kA-3b49A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3b49 LIN2189 PROTEIN
(Listeria
innocua) 		5 / 12 ILE A  60
GLU A  12
ILE A 186
GLU A  82
VAL A 111
 None
 1.26A 4a97B-3b49A:
undetectable
4a97C-3b49A:
undetectable		 4a97B-3b49A:
21.20
4a97C-3b49A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3b49 LIN2189 PROTEIN
(Listeria
innocua) 		5 / 12 PHE A   8
ILE A  60
GLU A  12
ILE A 186
VAL A 111
 None
 1.06A 4a97B-3b49A:
undetectable
4a97C-3b49A:
undetectable		 4a97B-3b49A:
21.20
4a97C-3b49A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3b49 LIN2189 PROTEIN
(Listeria
innocua) 		4 / 7 SER A  63
LYS A 120
LEU A 116
ALA A 119
 None
 1.03A 4ikkA-3b49A:
undetectable
4ikkB-3b49A:
undetectable		 4ikkA-3b49A:
21.96
4ikkB-3b49A:
21.96