SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA500_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392
(Methanocaldococc
us
jannaschii) 		4 / 4 ALA A  97
HIS A  58
HIS A  54
PRO A  99
 None
ZN  A 225 (-3.4A)
ZN  A 225 (-3.3A)
None
 1.48A 3mbgA-3b4rA:
1.4		 3mbgA-3b4rA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC900_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392
(Methanocaldococc
us
jannaschii) 		4 / 4 ALA A  97
HIS A  58
HIS A  54
PRO A  99
 None
ZN  A 225 (-3.4A)
ZN  A 225 (-3.3A)
None
 1.48A 3mbgC-3b4rA:
1.1		 3mbgC-3b4rA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392
(Methanocaldococc
us
jannaschii) 		3 / 4 SER A 102
GLY A 149
GLU A 207
 None
 0.56A 3raeA-3b4rA:
undetectable
3raeC-3b4rA:
undetectable		 3raeA-3b4rA:
19.96
3raeC-3b4rA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392
(Methanocaldococc
us
jannaschii) 		4 / 5 PHE A 202
ILE A 173
LEU A 177
LYS A 175
 None
 1.24A 3sueC-3b4rA:
undetectable		 3sueC-3b4rA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU A 193
ILE A 180
GLY A 185
PHE A 184
 None
 1.06A 4dc3A-3b4rA:
undetectable		 4dc3A-3b4rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392
(Methanocaldococc
us
jannaschii) 		3 / 4 SER A 102
GLY A 149
GLU A 207
 None
 0.60A 4juoA-3b4rA:
undetectable
4juoC-3b4rA:
undetectable		 4juoA-3b4rA:
19.96
4juoC-3b4rA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 157
ILE A 156
PHE A 145
LEU A 179
GLY A 149
 None
 1.16A 6a7pA-3b4rA:
3.5		 6a7pA-3b4rA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A 157
SER A 158
ARG A 154
PHE A 145
ILE A 169
 None
 1.14A 6ef6A-3b4rA:
undetectable		 6ef6A-3b4rA:
20.85