SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.04A 1fk9A-3b4tA:
undetectable		 1fk9A-3b4tA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 0.93A 1fkoA-3b4tA:
undetectable		 1fkoA-3b4tA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.02A 1fkpA-3b4tA:
undetectable		 1fkpA-3b4tA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.06A 1jkhA-3b4tA:
undetectable
1jkhB-3b4tA:
undetectable		 1jkhA-3b4tA:
18.72
1jkhB-3b4tA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.03A 1lw0A-3b4tA:
undetectable		 1lw0A-3b4tA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.12A 1lwcA-3b4tA:
undetectable		 1lwcA-3b4tA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 0.91A 1lwfA-3b4tA:
undetectable		 1lwfA-3b4tA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 230
PHE A 231
ALA A 232
LEU A  12
 None
 0.94A 1ukbA-3b4tA:
undetectable		 1ukbA-3b4tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 4 HIS A  35
ASP A 176
ASN A 190
ASP A 123
 None
None
PO4  A 260 ( 4.6A)
None
 1.48A 1wg8A-3b4tA:
undetectable		 1wg8A-3b4tA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.07A 2hndA-3b4tA:
undetectable		 2hndA-3b4tA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.11A 2hnyA-3b4tA:
undetectable		 2hnyA-3b4tA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 177
PRO A 178
ARG A 172
 None
 0.64A 2qd4B-3b4tA:
undetectable		 2qd4B-3b4tA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 119
GLY A 125
THR A 126
ALA A 129
 None
PO4  A 260 ( 3.7A)
PO4  A 260 ( 2.8A)
None
 0.69A 3aruA-3b4tA:
undetectable		 3aruA-3b4tA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
ALA A 107
GLY A  56
SER A 152
LEU A 151
 None
 1.31A 3gyqA-3b4tA:
undetectable
3gyqB-3b4tA:
undetectable		 3gyqA-3b4tA:
23.83
3gyqB-3b4tA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.17A 3lp0A-3b4tA:
undetectable		 3lp0A-3b4tA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.09A 3lp1A-3b4tA:
undetectable		 3lp1A-3b4tA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 0.93A 3mecA-3b4tA:
undetectable		 3mecA-3b4tA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 0.98A 3medA-3b4tA:
undetectable
3medB-3b4tA:
undetectable		 3medA-3b4tA:
18.72
3medB-3b4tA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.06A 3qipA-3b4tA:
undetectable		 3qipA-3b4tA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 134
ILE A  95
LEU A  99
ALA A  42
 None
 0.82A 3r9sA-3b4tA:
undetectable		 3r9sA-3b4tA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		3 / 3 TYR A  64
THR A 126
GLU A  90
 None
PO4  A 260 ( 2.8A)
None
 0.62A 4df3A-3b4tA:
undetectable		 4df3A-3b4tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		3 / 3 TYR A  64
THR A 126
GLU A  90
 None
PO4  A 260 ( 2.8A)
None
 0.62A 4df3B-3b4tA:
undetectable		 4df3B-3b4tA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  38
VAL A 136
PHE A  33
VAL A 192
VAL A  15
 None
 1.28A 4ib4A-3b4tA:
undetectable		 4ib4A-3b4tA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 5 SER A   1
LYS A   2
ARG A   3
LEU A   8
 None
 1.46A 4ifxA-3b4tA:
0.9		 4ifxA-3b4tA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 8 ARG A  87
ASP A 188
GLU A 207
ARG A 127
 PO4  A 260 ( 2.6A)
None
None
PO4  A 260 ( 3.9A)
 1.32A 4kr4C-3b4tA:
undetectable		 4kr4C-3b4tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 184
ARG A   3
ASP A 123
ARG A   7
 None
 1.22A 4kr4C-3b4tA:
undetectable		 4kr4C-3b4tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 4 ILE A  17
VAL A  38
VAL A  29
ARG A  19
 None
 1.05A 4m6tA-3b4tA:
undetectable		 4m6tA-3b4tA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 216
VAL A 166
VAL A 187
LEU A 220
 None
 0.97A 4pwdA-3b4tA:
undetectable		 4pwdA-3b4tA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  10
GLU A  11
ASP A   9
SER A   1
 None
 1.19A 4uhxA-3b4tA:
undetectable		 4uhxA-3b4tA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  10
GLU A  11
ASP A   9
SER A   1
 None
 1.19A 4uhxA-3b4tA:
undetectable		 4uhxA-3b4tA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  99
LEU A  60
GLY A  96
SER A  92
ALA A 137
 None
 1.01A 4xj7C-3b4tA:
undetectable
4xj7D-3b4tA:
undetectable		 4xj7C-3b4tA:
24.83
4xj7D-3b4tA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 6 ARG A  81
ARG A  87
GLY A  86
GLU A  90
 None
PO4  A 260 ( 2.6A)
PO4  A 259 ( 3.8A)
None
 0.98A 5cdqA-3b4tA:
undetectable
5cdqC-3b4tA:
undetectable
5cdqD-3b4tA:
undetectable		 5cdqA-3b4tA:
20.42
5cdqC-3b4tA:
20.42
5cdqD-3b4tA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 119
ALA A  65
ILE A  91
THR A  88
 None
 1.17A 5e4dB-3b4tA:
undetectable		 5e4dB-3b4tA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.14A 6bsgA-3b4tA:
undetectable		 6bsgA-3b4tA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3b4t RIBONUCLEASE PH
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.13A 6bsjA-3b4tA:
undetectable		 6bsjA-3b4tA:
13.36