SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 1c9sB-3b4wA:
undetectable
1c9sC-3b4wA:
undetectable
1c9sB-3b4wA:
10.29
1c9sC-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.28A 1c9sC-3b4wA:
undetectable
1c9sD-3b4wA:
undetectable
1c9sC-3b4wA:
10.29
1c9sD-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 1c9sF-3b4wA:
undetectable
1c9sG-3b4wA:
undetectable
1c9sF-3b4wA:
10.29
1c9sG-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 1c9sS-3b4wA:
undetectable
1c9sT-3b4wA:
undetectable
1c9sS-3b4wA:
10.29
1c9sT-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 7 GLY A 417
ALA A 408
THR A 436
SER A 411
None
0.89A 1c9sT-3b4wA:
undetectable
1c9sU-3b4wA:
undetectable
1c9sT-3b4wA:
10.29
1c9sU-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 PHE A 161
THR A 231
GLY A 453
THR A 438
VAL A 289
GOL  A 602 (-4.0A)
NAD  A 500 (-4.1A)
None
None
GOL  A 602 ( 4.6A)
1.40A 1dz8A-3b4wA:
undetectable
1dz8A-3b4wA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 PHE A 161
THR A 231
GLY A 453
THR A 438
VAL A 289
GOL  A 602 (-4.0A)
NAD  A 500 (-4.1A)
None
None
GOL  A 602 ( 4.6A)
1.39A 1dz8B-3b4wA:
undetectable
1dz8B-3b4wA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 PHE A 161
THR A 231
GLY A 453
THR A 438
VAL A 289
GOL  A 602 (-4.0A)
NAD  A 500 (-4.1A)
None
None
GOL  A 602 ( 4.6A)
1.35A 1dz9B-3b4wA:
undetectable
1dz9B-3b4wA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 SER A 234
LEU A 415
TYR A 413
GLY A 232
PHE A 389
None
NAD  A 500 ( 4.6A)
None
NAD  A 500 (-3.0A)
NAD  A 500 (-3.9A)
1.46A 1fdsA-3b4wA:
4.9
1fdsA-3b4wA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 7 GLY A 417
ALA A 408
THR A 436
SER A 411
None
0.87A 1gtfL-3b4wA:
undetectable
1gtfM-3b4wA:
undetectable
1gtfL-3b4wA:
10.29
1gtfM-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 8 GLY A 417
ALA A 408
THR A 436
SER A 411
None
0.87A 1gtfN-3b4wA:
undetectable
1gtfO-3b4wA:
undetectable
1gtfN-3b4wA:
10.29
1gtfO-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 8 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 1gtnA-3b4wA:
undetectable
1gtnB-3b4wA:
undetectable
1gtnA-3b4wA:
10.29
1gtnB-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.37A 1gtnN-3b4wA:
undetectable
1gtnO-3b4wA:
undetectable
1gtnN-3b4wA:
10.29
1gtnO-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 346
GLU A 340
GLY A 341
GLY A 357
GLY A 358
None
1.00A 1mxdA-3b4wA:
undetectable
1mxdA-3b4wA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 11 GLY A 346
GLU A 340
GLY A 341
GLY A 357
GLY A 358
None
1.01A 1mxgA-3b4wA:
undetectable
1mxgA-3b4wA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.23A 1utdA-3b4wA:
undetectable
1utdB-3b4wA:
undetectable
1utdA-3b4wA:
10.29
1utdB-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 8 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.26A 1utdB-3b4wA:
undetectable
1utdC-3b4wA:
undetectable
1utdB-3b4wA:
10.29
1utdC-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.26A 1utdD-3b4wA:
undetectable
1utdE-3b4wA:
undetectable
1utdD-3b4wA:
10.29
1utdE-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 8 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.25A 1utdJ-3b4wA:
undetectable
1utdK-3b4wA:
undetectable
1utdJ-3b4wA:
10.29
1utdK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 5 PRO A 391
VAL A 281
VAL A 312
ILE A 327
None
1.06A 1z2bC-3b4wA:
undetectable
1z2bC-3b4wA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 7 MET A 108
GLY A 280
THR A 292
ILE A 388
GOL  A 602 ( 4.9A)
None
None
None
0.90A 2bdmA-3b4wA:
undetectable
2bdmA-3b4wA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 6 LEU A 160
LEU A 192
PRO A 181
VAL A 208
None
1.15A 2dqyC-3b4wA:
undetectable
2dqyC-3b4wA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 6 SER A 411
SER A 458
LEU A 415
GLY A 414
None
None
NAD  A 500 ( 4.6A)
None
0.91A 2j2pA-3b4wA:
undetectable
2j2pC-3b4wA:
undetectable
2j2pA-3b4wA:
16.43
2j2pC-3b4wA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 6 SER A 411
SER A 458
LEU A 415
GLY A 414
None
None
NAD  A 500 ( 4.6A)
None
0.90A 2j2pD-3b4wA:
undetectable
2j2pF-3b4wA:
undetectable
2j2pD-3b4wA:
16.43
2j2pF-3b4wA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 GLY A 174
ALA A 173
LEU A 206
VAL A  52
LEU A 219
None
1.03A 2nyuA-3b4wA:
2.7
2nyuA-3b4wA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 LEU A  94
GLN A 286
LEU A 179
PRO A 181
VAL A 208
None
1.24A 2qd4A-3b4wA:
undetectable
2qd4A-3b4wA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 LEU A  94
GLN A 286
LEU A 179
PRO A 181
VAL A 208
None
1.27A 2qd4B-3b4wA:
2.0
2qd4B-3b4wA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
3 / 3 PHE A 452
ASN A 464
PHE A 161
NAD  A 500 (-4.6A)
None
GOL  A 602 (-4.0A)
0.94A 2zbuD-3b4wA:
undetectable
2zbuD-3b4wA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 TRP A 110
ALA A 168
ALA A 152
VAL A 154
LEU A  94
None
1.05A 3b0wB-3b4wA:
undetectable
3b0wB-3b4wA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 TYR A 444
GLY A 414
GLY A 437
VAL A 412
SER A 458
None
1.32A 3dlcA-3b4wA:
undetectable
3dlcA-3b4wA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 4 GLU A  97
GLY A  38
THR A   6
GLU A   7
None
0.98A 3e9xA-3b4wA:
undetectable
3e9xA-3b4wA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 LEU A 187
THR A 188
ALA A 191
GLU A 194
LEU A  94
None
1.07A 3hm1A-3b4wA:
undetectable
3hm1A-3b4wA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 LEU A 187
THR A 188
ALA A 191
LEU A  89
LEU A  94
None
1.10A 3hm1A-3b4wA:
undetectable
3hm1A-3b4wA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 GLY A 148
PRO A 146
ALA A 173
ILE A 225
PRO A  65
None
1.12A 3jayA-3b4wA:
undetectable
3jayA-3b4wA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 7 LEU A 393
ALA A 261
VAL A 267
ILE A 294
None
0.85A 3wsjB-3b4wA:
undetectable
3wsjB-3b4wA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 GLY A 390
ALA A 284
ASN A 283
ILE A 388
VAL A 339
None
1.23A 4azwA-3b4wA:
4.7
4azwA-3b4wA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 GLY A 211
ALA A  43
THR A  22
VAL A  48
ALA A 182
None
None
None
None
NAD  A 500 (-4.0A)
1.45A 4df3A-3b4wA:
3.5
4df3A-3b4wA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 GLY A 211
ALA A  43
THR A  22
VAL A  48
ALA A 182
None
None
None
None
NAD  A 500 (-4.0A)
1.44A 4df3B-3b4wA:
3.7
4df3B-3b4wA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 4 ALA A  50
ALA A  53
ALA A  54
ALA A  57
None
0.13A 4oadA-3b4wA:
undetectable
4oadA-3b4wA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 4 ALA A  50
ALA A  53
ALA A  54
ALA A  57
None
0.12A 4oaeA-3b4wA:
undetectable
4oaeA-3b4wA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
3 / 3 GLY A 328
PRO A 329
GLN A 286
None
0.45A 4oltB-3b4wA:
undetectable
4oltB-3b4wA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 5 THR A 438
THR A 252
HIS A 471
ASN A 464
None
None
GOL  A 603 (-3.7A)
None
1.22A 4pgfB-3b4wA:
3.3
4pgfB-3b4wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 GLY A 417
GLY A 440
ILE A 434
SER A 431
ALA A 416
None
1.05A 4qtuB-3b4wA:
4.0
4qtuB-3b4wA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 GLY A 417
GLY A 440
ILE A 434
SER A 431
ALA A 416
None
0.99A 4qtuD-3b4wA:
4.0
4qtuD-3b4wA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
3 / 3 GLY A 328
PRO A 329
GLN A 286
None
0.30A 4qwpB-3b4wA:
undetectable
4qwpB-3b4wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 GLY A 232
GLY A 256
GLY A 459
LEU A 253
GLU A 184
NAD  A 500 (-3.0A)
NAD  A 500 (-3.3A)
None
None
None
0.99A 5c0oG-3b4wA:
4.0
5c0oG-3b4wA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.28A 5eeuA-3b4wA:
undetectable
5eeuB-3b4wA:
undetectable
5eeuA-3b4wA:
10.29
5eeuB-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.25A 5eeuB-3b4wA:
undetectable
5eeuC-3b4wA:
undetectable
5eeuB-3b4wA:
10.29
5eeuC-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.26A 5eeuC-3b4wA:
undetectable
5eeuD-3b4wA:
undetectable
5eeuC-3b4wA:
10.29
5eeuD-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.30A 5eeuD-3b4wA:
undetectable
5eeuE-3b4wA:
undetectable
5eeuD-3b4wA:
10.29
5eeuE-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 5eeuE-3b4wA:
undetectable
5eeuF-3b4wA:
undetectable
5eeuE-3b4wA:
10.29
5eeuF-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eeuH-3b4wA:
undetectable
5eeuI-3b4wA:
undetectable
5eeuH-3b4wA:
10.29
5eeuI-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eeuJ-3b4wA:
undetectable
5eeuK-3b4wA:
undetectable
5eeuJ-3b4wA:
10.29
5eeuK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.24A 5eeuA-3b4wA:
undetectable
5eeuK-3b4wA:
undetectable
5eeuA-3b4wA:
10.29
5eeuK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.32A 5eeuP-3b4wA:
undetectable
5eeuQ-3b4wA:
undetectable
5eeuP-3b4wA:
10.29
5eeuQ-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 5eeuS-3b4wA:
undetectable
5eeuT-3b4wA:
undetectable
5eeuS-3b4wA:
10.29
5eeuT-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.25A 5eevB-3b4wA:
undetectable
5eevC-3b4wA:
undetectable
5eevB-3b4wA:
10.29
5eevC-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.26A 5eevC-3b4wA:
undetectable
5eevD-3b4wA:
undetectable
5eevC-3b4wA:
10.29
5eevD-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.30A 5eevD-3b4wA:
undetectable
5eevE-3b4wA:
undetectable
5eevD-3b4wA:
10.29
5eevE-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 5eevE-3b4wA:
undetectable
5eevF-3b4wA:
undetectable
5eevE-3b4wA:
10.29
5eevF-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eevH-3b4wA:
undetectable
5eevI-3b4wA:
undetectable
5eevH-3b4wA:
10.29
5eevI-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eevJ-3b4wA:
undetectable
5eevK-3b4wA:
undetectable
5eevJ-3b4wA:
10.29
5eevK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.24A 5eevA-3b4wA:
undetectable
5eevK-3b4wA:
undetectable
5eevA-3b4wA:
10.29
5eevK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.32A 5eevP-3b4wA:
undetectable
5eevQ-3b4wA:
undetectable
5eevP-3b4wA:
10.29
5eevQ-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 5eevS-3b4wA:
undetectable
5eevT-3b4wA:
undetectable
5eevS-3b4wA:
10.29
5eevT-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.25A 5eewB-3b4wA:
undetectable
5eewC-3b4wA:
undetectable
5eewB-3b4wA:
10.29
5eewC-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.26A 5eewC-3b4wA:
undetectable
5eewD-3b4wA:
undetectable
5eewC-3b4wA:
10.29
5eewD-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.30A 5eewD-3b4wA:
undetectable
5eewE-3b4wA:
undetectable
5eewD-3b4wA:
10.29
5eewE-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 5eewE-3b4wA:
undetectable
5eewF-3b4wA:
undetectable
5eewE-3b4wA:
10.29
5eewF-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eewH-3b4wA:
undetectable
5eewI-3b4wA:
undetectable
5eewH-3b4wA:
10.29
5eewI-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eewJ-3b4wA:
undetectable
5eewK-3b4wA:
undetectable
5eewJ-3b4wA:
10.29
5eewK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.24A 5eewA-3b4wA:
undetectable
5eewK-3b4wA:
undetectable
5eewA-3b4wA:
10.29
5eewK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.32A 5eewP-3b4wA:
undetectable
5eewQ-3b4wA:
undetectable
5eewP-3b4wA:
10.29
5eewQ-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 5eewS-3b4wA:
undetectable
5eewT-3b4wA:
undetectable
5eewS-3b4wA:
10.29
5eewT-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.25A 5eexB-3b4wA:
undetectable
5eexC-3b4wA:
undetectable
5eexB-3b4wA:
10.29
5eexC-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.26A 5eexC-3b4wA:
undetectable
5eexD-3b4wA:
undetectable
5eexC-3b4wA:
10.29
5eexD-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.30A 5eexD-3b4wA:
undetectable
5eexE-3b4wA:
undetectable
5eexD-3b4wA:
10.29
5eexE-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 5eexE-3b4wA:
undetectable
5eexF-3b4wA:
undetectable
5eexE-3b4wA:
10.29
5eexF-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eexH-3b4wA:
undetectable
5eexI-3b4wA:
undetectable
5eexH-3b4wA:
10.29
5eexI-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eexJ-3b4wA:
undetectable
5eexK-3b4wA:
undetectable
5eexJ-3b4wA:
10.29
5eexK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.24A 5eexA-3b4wA:
undetectable
5eexK-3b4wA:
undetectable
5eexA-3b4wA:
10.29
5eexK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.32A 5eexP-3b4wA:
undetectable
5eexQ-3b4wA:
undetectable
5eexP-3b4wA:
10.29
5eexQ-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.29A 5eexQ-3b4wA:
undetectable
5eexR-3b4wA:
undetectable
5eexQ-3b4wA:
10.29
5eexR-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 5eexS-3b4wA:
undetectable
5eexT-3b4wA:
undetectable
5eexS-3b4wA:
10.29
5eexT-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.25A 5eeyB-3b4wA:
undetectable
5eeyC-3b4wA:
undetectable
5eeyB-3b4wA:
10.29
5eeyC-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.26A 5eeyC-3b4wA:
undetectable
5eeyD-3b4wA:
undetectable
5eeyC-3b4wA:
10.29
5eeyD-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.30A 5eeyD-3b4wA:
undetectable
5eeyE-3b4wA:
undetectable
5eeyD-3b4wA:
10.29
5eeyE-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 5eeyE-3b4wA:
undetectable
5eeyF-3b4wA:
undetectable
5eeyE-3b4wA:
10.29
5eeyF-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eeyH-3b4wA:
undetectable
5eeyI-3b4wA:
undetectable
5eeyH-3b4wA:
10.29
5eeyI-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eeyJ-3b4wA:
undetectable
5eeyK-3b4wA:
undetectable
5eeyJ-3b4wA:
10.29
5eeyK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.24A 5eeyA-3b4wA:
undetectable
5eeyK-3b4wA:
undetectable
5eeyA-3b4wA:
10.29
5eeyK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.32A 5eeyP-3b4wA:
undetectable
5eeyQ-3b4wA:
undetectable
5eeyP-3b4wA:
10.29
5eeyQ-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.29A 5eeyQ-3b4wA:
undetectable
5eeyR-3b4wA:
undetectable
5eeyQ-3b4wA:
10.29
5eeyR-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 5eeyS-3b4wA:
undetectable
5eeyT-3b4wA:
undetectable
5eeyS-3b4wA:
10.29
5eeyT-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.25A 5eezB-3b4wA:
undetectable
5eezC-3b4wA:
undetectable
5eezB-3b4wA:
10.29
5eezC-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.26A 5eezC-3b4wA:
undetectable
5eezD-3b4wA:
undetectable
5eezC-3b4wA:
10.29
5eezD-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.30A 5eezD-3b4wA:
undetectable
5eezE-3b4wA:
undetectable
5eezD-3b4wA:
10.29
5eezE-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 5eezE-3b4wA:
undetectable
5eezF-3b4wA:
undetectable
5eezE-3b4wA:
10.29
5eezF-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eezH-3b4wA:
undetectable
5eezI-3b4wA:
undetectable
5eezH-3b4wA:
10.29
5eezI-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5eezJ-3b4wA:
undetectable
5eezK-3b4wA:
undetectable
5eezJ-3b4wA:
10.29
5eezK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.24A 5eezA-3b4wA:
undetectable
5eezK-3b4wA:
undetectable
5eezA-3b4wA:
10.29
5eezK-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 8 SER A 411
GLY A 417
ALA A 408
THR A 436
None
0.86A 5eezL-3b4wA:
undetectable
5eezV-3b4wA:
undetectable
5eezL-3b4wA:
10.29
5eezV-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.32A 5eezP-3b4wA:
undetectable
5eezQ-3b4wA:
undetectable
5eezP-3b4wA:
10.29
5eezQ-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.29A 5eezQ-3b4wA:
undetectable
5eezR-3b4wA:
undetectable
5eezQ-3b4wA:
10.29
5eezR-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 5eezS-3b4wA:
undetectable
5eezT-3b4wA:
undetectable
5eezS-3b4wA:
10.29
5eezT-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.25A 5ef0B-3b4wA:
undetectable
5ef0C-3b4wA:
undetectable
5ef0B-3b4wA:
10.29
5ef0C-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.26A 5ef0C-3b4wA:
undetectable
5ef0D-3b4wA:
undetectable
5ef0C-3b4wA:
10.29
5ef0D-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.30A 5ef0D-3b4wA:
undetectable
5ef0E-3b4wA:
undetectable
5ef0D-3b4wA:
10.29
5ef0E-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 5ef0E-3b4wA:
undetectable
5ef0F-3b4wA:
undetectable
5ef0E-3b4wA:
10.29
5ef0F-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5ef0H-3b4wA:
undetectable
5ef0I-3b4wA:
undetectable
5ef0H-3b4wA:
10.29
5ef0I-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5ef0J-3b4wA:
undetectable
5ef0K-3b4wA:
undetectable
5ef0J-3b4wA:
10.29
5ef0K-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.24A 5ef0A-3b4wA:
undetectable
5ef0K-3b4wA:
undetectable
5ef0A-3b4wA:
10.29
5ef0K-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.32A 5ef0P-3b4wA:
undetectable
5ef0Q-3b4wA:
undetectable
5ef0P-3b4wA:
10.29
5ef0Q-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.29A 5ef0Q-3b4wA:
undetectable
5ef0R-3b4wA:
undetectable
5ef0Q-3b4wA:
10.29
5ef0R-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 5ef0S-3b4wA:
undetectable
5ef0T-3b4wA:
undetectable
5ef0S-3b4wA:
10.29
5ef0T-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.25A 5ef1B-3b4wA:
undetectable
5ef1C-3b4wA:
undetectable
5ef1B-3b4wA:
10.29
5ef1C-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.26A 5ef1C-3b4wA:
undetectable
5ef1D-3b4wA:
undetectable
5ef1C-3b4wA:
10.29
5ef1D-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.30A 5ef1D-3b4wA:
undetectable
5ef1E-3b4wA:
undetectable
5ef1D-3b4wA:
10.29
5ef1E-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 5ef1E-3b4wA:
undetectable
5ef1F-3b4wA:
undetectable
5ef1E-3b4wA:
10.29
5ef1F-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5ef1H-3b4wA:
undetectable
5ef1I-3b4wA:
undetectable
5ef1H-3b4wA:
10.29
5ef1I-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5ef1J-3b4wA:
undetectable
5ef1K-3b4wA:
undetectable
5ef1J-3b4wA:
10.29
5ef1K-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.24A 5ef1A-3b4wA:
undetectable
5ef1K-3b4wA:
undetectable
5ef1A-3b4wA:
10.29
5ef1K-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 8 SER A 411
GLY A 417
ALA A 408
THR A 436
None
0.86A 5ef1L-3b4wA:
undetectable
5ef1V-3b4wA:
undetectable
5ef1L-3b4wA:
10.29
5ef1V-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.32A 5ef1P-3b4wA:
undetectable
5ef1Q-3b4wA:
undetectable
5ef1P-3b4wA:
10.29
5ef1Q-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.29A 5ef1Q-3b4wA:
undetectable
5ef1R-3b4wA:
undetectable
5ef1Q-3b4wA:
10.29
5ef1R-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 5ef1S-3b4wA:
undetectable
5ef1T-3b4wA:
undetectable
5ef1S-3b4wA:
10.29
5ef1T-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.25A 5ef2B-3b4wA:
undetectable
5ef2C-3b4wA:
undetectable
5ef2B-3b4wA:
10.29
5ef2C-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.26A 5ef2C-3b4wA:
undetectable
5ef2D-3b4wA:
undetectable
5ef2C-3b4wA:
10.29
5ef2D-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.30A 5ef2D-3b4wA:
undetectable
5ef2E-3b4wA:
undetectable
5ef2D-3b4wA:
10.29
5ef2E-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 5ef2E-3b4wA:
undetectable
5ef2F-3b4wA:
undetectable
5ef2E-3b4wA:
10.29
5ef2F-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5ef2H-3b4wA:
undetectable
5ef2I-3b4wA:
undetectable
5ef2H-3b4wA:
10.29
5ef2I-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5ef2J-3b4wA:
undetectable
5ef2K-3b4wA:
undetectable
5ef2J-3b4wA:
10.29
5ef2K-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.24A 5ef2A-3b4wA:
undetectable
5ef2K-3b4wA:
undetectable
5ef2A-3b4wA:
10.29
5ef2K-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 8 SER A 411
GLY A 417
ALA A 408
THR A 436
None
0.86A 5ef2L-3b4wA:
undetectable
5ef2V-3b4wA:
undetectable
5ef2L-3b4wA:
10.29
5ef2V-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.32A 5ef2P-3b4wA:
undetectable
5ef2Q-3b4wA:
undetectable
5ef2P-3b4wA:
10.29
5ef2Q-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.29A 5ef2Q-3b4wA:
undetectable
5ef2R-3b4wA:
undetectable
5ef2Q-3b4wA:
10.29
5ef2R-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 5ef2S-3b4wA:
undetectable
5ef2T-3b4wA:
undetectable
5ef2S-3b4wA:
10.29
5ef2T-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.25A 5ef3B-3b4wA:
undetectable
5ef3C-3b4wA:
undetectable
5ef3B-3b4wA:
10.29
5ef3C-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.26A 5ef3C-3b4wA:
undetectable
5ef3D-3b4wA:
undetectable
5ef3C-3b4wA:
10.29
5ef3D-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.30A 5ef3D-3b4wA:
undetectable
5ef3E-3b4wA:
undetectable
5ef3D-3b4wA:
10.29
5ef3E-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.29A 5ef3E-3b4wA:
undetectable
5ef3F-3b4wA:
undetectable
5ef3E-3b4wA:
10.29
5ef3F-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5ef3H-3b4wA:
undetectable
5ef3I-3b4wA:
undetectable
5ef3H-3b4wA:
10.29
5ef3I-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
None
1.27A 5ef3J-3b4wA:
undetectable
5ef3K-3b4wA:
undetectable
5ef3J-3b4wA:
10.29
5ef3K-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.24A 5ef3A-3b4wA:
undetectable
5ef3K-3b4wA:
undetectable
5ef3A-3b4wA:
10.29
5ef3K-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.32A 5ef3P-3b4wA:
undetectable
5ef3Q-3b4wA:
undetectable
5ef3P-3b4wA:
10.29
5ef3Q-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.29A 5ef3Q-3b4wA:
undetectable
5ef3R-3b4wA:
undetectable
5ef3Q-3b4wA:
10.29
5ef3R-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 417
ALA A 408
THR A 436
ILE A 434
SER A 411
None
1.28A 5ef3S-3b4wA:
undetectable
5ef3T-3b4wA:
undetectable
5ef3S-3b4wA:
10.29
5ef3T-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
3 / 3 VAL A 377
ARG A 336
PRO A 391
None
0.87A 5koxA-3b4wA:
undetectable
5koxA-3b4wA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 ALA A  44
SER A  21
GLY A 216
ALA A 218
ASP A  49
None
None
NAD  A 500 (-3.5A)
None
None
1.15A 5l66K-3b4wA:
undetectable
5l66L-3b4wA:
undetectable
5l66K-3b4wA:
18.16
5l66L-3b4wA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 ALA A  44
SER A  21
GLY A 216
ALA A 218
ASP A  49
None
None
NAD  A 500 (-3.5A)
None
None
1.15A 5l66Y-3b4wA:
undetectable
5l66Z-3b4wA:
undetectable
5l66Y-3b4wA:
18.16
5l66Z-3b4wA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 7 LEU A 415
SER A 411
ILE A 388
GLU A 387
NAD  A 500 ( 4.6A)
None
None
NAD  A 500 (-2.8A)
0.99A 5n5dA-3b4wA:
5.3
5n5dA-3b4wA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 5 GLY A  62
PRO A  65
TRP A  64
CYH A 175
None
1.34A 5nn8A-3b4wA:
undetectable
5nn8A-3b4wA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 4 PRO A 297
MET A 276
GLY A 280
VAL A 308
None
1.17A 6ak3A-3b4wA:
undetectable
6ak3A-3b4wA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 8 GLY A 437
GLY A 257
SER A 259
ALA A 260
None
0.76A 6hu9H-3b4wA:
undetectable
6hu9e-3b4wA:
undetectable
6hu9H-3b4wA:
10.99
6hu9e-3b4wA:
14.29