SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 332
LEU A   6
LEU A  69
SER A  34
 None
 0.95A 1dvtA-3b4yA:
undetectable
1dvtB-3b4yA:
undetectable		 1dvtA-3b4yA:
16.82
1dvtB-3b4yA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 8 PRO A  77
SER A 135
VAL A  74
GLY A 104
 None
None
F42  A 338 (-4.3A)
None
 1.13A 2qd3A-3b4yA:
undetectable		 2qd3A-3b4yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 227
ARG A 212
VAL A 211
 None
 0.83A 2r2vC-3b4yA:
undetectable
2r2vD-3b4yA:
undetectable		 2r2vC-3b4yA:
10.78
2r2vD-3b4yA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 108
PRO A  77
LEU A 132
 F42  A 338 (-3.7A)
None
None
 0.60A 3hcpB-3b4yA:
undetectable		 3hcpB-3b4yA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		3 / 3 THR A 204
LYS A 259
GLU A 201
 None
FLC  A 337 (-2.8A)
None
 0.81A 3ijdB-3b4yA:
14.0		 3ijdB-3b4yA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 102
ASP A 226
TYR A 173
LEU A  68
 None
 0.85A 3jq7B-3b4yA:
2.2		 3jq7B-3b4yA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 102
ASP A 226
TYR A 173
LEU A  68
 None
 0.85A 3jq7C-3b4yA:
undetectable		 3jq7C-3b4yA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 104
TYR A 173
GLY A 191
ASP A 190
 None
 1.01A 3kl3A-3b4yA:
10.4		 3kl3A-3b4yA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		3 / 3 THR A 195
SER A 196
ARG A 283
 FLC  A 337 ( 3.4A)
None
FLC  A 337 (-2.8A)
 0.75A 3phnA-3b4yA:
undetectable		 3phnA-3b4yA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 7 ARG A  45
ALA A 250
TRP A 249
ALA A 272
 None
 1.28A 3tx2A-3b4yA:
undetectable		 3tx2A-3b4yA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 317
PHE A 320
TYR A   8
 None
 0.88A 3ucjB-3b4yA:
undetectable		 3ucjB-3b4yA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 317
PHE A 320
TYR A   8
 None
 0.92A 3ucjA-3b4yA:
undetectable		 3ucjA-3b4yA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 317
GLN A  14
ASN A 245
THR A 246
 None
 1.06A 4d1yA-3b4yA:
undetectable
4d1yB-3b4yA:
undetectable		 4d1yA-3b4yA:
22.74
4d1yB-3b4yA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 177
ARG A 283
MET A 208
PHE A 192
 F42  A 338 (-3.4A)
FLC  A 337 (-2.8A)
None
None
 0.99A 4j4vC-3b4yA:
undetectable		 4j4vC-3b4yA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 181
ALA A 185
PHE A 192
TYR A 203
 F42  A 338 (-4.3A)
None
None
None
 0.92A 4lb2A-3b4yA:
1.2		 4lb2A-3b4yA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  68
GLY A  62
SER A  34
VAL A  37
ALA A  24
 None
 1.00A 5o96G-3b4yA:
4.4		 5o96G-3b4yA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 235
ASP A 291
ASP A 327
 None
 0.79A 5x6yA-3b4yA:
2.2		 5x6yA-3b4yA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  96
THR A  59
GLY A  62
ARG A 100
 CSO  A  95 ( 4.3A)
None
None
None
 1.30A 6gtqB-3b4yA:
undetectable
6gtqD-3b4yA:
undetectable		 6gtqB-3b4yA:
19.60
6gtqD-3b4yA:
9.22