SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 135
VAL A  78
PHE A   9
VAL A  22
ILE A  25
 None
 1.13A 1c9hA-3b54A:
undetectable		 1c9hA-3b54A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A  14
GLY A 110
ASN A 116
SER A  71
GLY A 114
 None
None
PO4  A 154 ( 4.3A)
None
None
 1.13A 1ffyA-3b54A:
undetectable		 1ffyA-3b54A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 119
ILE A  74
LEU A  48
 PO4  A 154 (-3.6A)
None
None
 0.68A 2kceA-3b54A:
undetectable		 2kceA-3b54A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ARG A  19
LEU A  21
ILE A  91
GLY A 103
VAL A 117
ILE A  25
 None
 1.31A 2q64B-3b54A:
undetectable		 2q64B-3b54A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		5 / 9 ARG A  19
ILE A  91
GLY A 103
VAL A 117
ILE A  25
 None
 1.19A 2r5qA-3b54A:
undetectable		 2r5qA-3b54A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		5 / 9 ARG A  19
ILE A  91
GLY A 103
VAL A 117
ILE A  25
 None
 1.19A 2r5qC-3b54A:
undetectable		 2r5qC-3b54A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ARG A  19
LEU A  21
ILE A  91
GLY A 103
VAL A 117
ILE A  25
 None
 1.31A 3em6B-3b54A:
undetectable		 3em6B-3b54A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 122
ARG A  89
ARG A 129
 None
PO4  A 154 (-4.2A)
None
 0.98A 3k37A-3b54A:
undetectable		 3k37A-3b54A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		5 / 11 ARG A  19
ILE A  91
GLY A 103
VAL A 117
ILE A  25
 None
 1.08A 3oxvD-3b54A:
undetectable		 3oxvD-3b54A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  29
ILE A  91
GLY A 120
CYH A 118
 None
None
PO4  A 154 ( 4.8A)
None
 1.30A 3r0lD-3b54A:
undetectable		 3r0lD-3b54A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUM_A_CCSA375_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		4 / 4 GLN A 147
SER A 145
GLY A  33
LYS A  35
 None
 1.32A 3rumA-3b54A:
0.0		 3rumA-3b54A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 119
GLU A 130
ASP A 122
SER A 126
 PO4  A 154 (-3.6A)
None
None
None
 1.18A 4apjA-3b54A:
undetectable
4apjP-3b54A:
undetectable		 4apjA-3b54A:
14.72
4apjP-3b54A:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ARG A  19
LEU A  21
ILE A  91
GLY A 103
VAL A 117
ILE A  25
 None
 1.21A 4dqbA-3b54A:
undetectable		 4dqbA-3b54A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ARG A  19
LEU A  21
ILE A  91
GLY A 103
VAL A 117
ILE A  25
 None
 1.26A 4dqfA-3b54A:
undetectable		 4dqfA-3b54A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  21
ILE A  25
ARG A  28
 None
 0.67A 4mk4B-3b54A:
undetectable		 4mk4B-3b54A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ARG A  19
LEU A  21
ILE A  91
GLY A 103
VAL A 117
ILE A  25
 None
 1.19A 4q1xB-3b54A:
undetectable		 4q1xB-3b54A:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 135
VAL A  78
PHE A   9
VAL A  22
ILE A  25
 None
 1.16A 5hkgA-3b54A:
undetectable		 5hkgA-3b54A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  86
LYS A  82
TYR A  34
 None
 0.83A 6gnaA-3b54A:
undetectable		 6gnaA-3b54A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3b54 NUCLEOSIDE
DIPHOSPHATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  86
LYS A  82
TYR A  34
 None
 0.83A 6gnbA-3b54A:
undetectable		 6gnbA-3b54A:
21.23