SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 11 ASN A 235
GLY A 226
GLY A 280
PHE A 237
ASP A 275
None
1.22A 1ho5A-3b59A:
undetectable
1ho5A-3b59A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q72_H_COCH401_1
(FAB M82G2, HEAVY
CHAIN
FAB M82G2, LIGHT
CHAIN)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 10 ASN A 234
GLN A 276
GLY A 228
HIS A 198
TYR A 239
None
None
None
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
1.42A 1q72H-3b59A:
0.0
1q72L-3b59A:
0.0
1q72H-3b59A:
22.46
1q72L-3b59A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
4 / 8 ARG A  10
LEU A  70
LEU A 196
VAL A 199
None
0.93A 2bdmA-3b59A:
undetectable
2bdmA-3b59A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
4 / 6 MET A 210
HIS A 214
ASP A 222
TYR A 250
None
1.42A 2lh8A-3b59A:
undetectable
2lh8A-3b59A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
4 / 6 PHE A  19
ARG A  58
ASN A  63
LEU A 147
None
1.30A 2nyrA-3b59A:
undetectable
2nyrA-3b59A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
4 / 4 GLY A 226
GLY A 282
GLY A 283
GLY A 224
None
0.67A 3bogC-3b59A:
undetectable
3bogC-3b59A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
3 / 3 SER A 252
ASP A 202
ASP A 207
None
0.65A 3iv6A-3b59A:
undetectable
3iv6A-3b59A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
3 / 3 SER A 252
ASP A 202
ASP A 207
None
0.65A 3iv6C-3b59A:
undetectable
3iv6C-3b59A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 12 ALA A 188
LEU A 147
ASN A 197
ILE A   9
ILE A  68
None
1.01A 3ut5B-3b59A:
undetectable
3ut5B-3b59A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
4 / 8 VAL A 146
HIS A 144
PRO A 284
TRP A 225
None
MN  A 602 (-3.5A)
None
None
1.25A 3v35A-3b59A:
undetectable
3v35A-3b59A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 12 TYR A 201
ILE A 142
VAL A  55
THR A 242
ILE A 145
None
1.21A 3vrjA-3b59A:
undetectable
3vrjC-3b59A:
undetectable
3vrjA-3b59A:
22.40
3vrjC-3b59A:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 11 HIS A 198
TYR A 239
GLU A 249
HIS A 144
ALA A 188
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
MN  A 602 (-3.5A)
None
0.52A 4ir0A-3b59A:
7.8
4ir0B-3b59A:
8.1
4ir0A-3b59A:
16.67
4ir0B-3b59A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 11 HIS A 144
ALA A 188
HIS A 198
TYR A 239
GLU A 249
MN  A 602 (-3.5A)
None
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
0.44A 4ir0A-3b59A:
7.8
4ir0B-3b59A:
8.1
4ir0A-3b59A:
16.67
4ir0B-3b59A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 12 HIS A 198
TYR A 239
GLU A 249
HIS A 144
ALA A 188
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
MN  A 602 (-3.5A)
None
0.45A 4jd1A-3b59A:
7.9
4jd1B-3b59A:
8.0
4jd1A-3b59A:
16.67
4jd1B-3b59A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 12 HIS A 144
ALA A 188
HIS A 198
TYR A 239
GLU A 249
MN  A 602 (-3.5A)
None
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
0.55A 4jd1A-3b59A:
7.9
4jd1B-3b59A:
8.0
4jd1A-3b59A:
16.67
4jd1B-3b59A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 12 HIS A 198
TYR A 239
GLU A 249
HIS A 144
ALA A 188
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
MN  A 602 (-3.5A)
None
0.44A 4jh3A-3b59A:
7.8
4jh3B-3b59A:
8.0
4jh3A-3b59A:
18.06
4jh3B-3b59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 11 HIS A 144
ALA A 188
HIS A 198
TYR A 239
GLU A 249
MN  A 602 (-3.5A)
None
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
0.42A 4jh3A-3b59A:
7.8
4jh3B-3b59A:
8.0
4jh3A-3b59A:
18.06
4jh3B-3b59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 11 HIS A 198
TYR A 239
GLU A 249
HIS A 144
ALA A 188
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
MN  A 602 (-3.5A)
None
0.41A 4jh4A-3b59A:
7.9
4jh4B-3b59A:
7.8
4jh4A-3b59A:
18.06
4jh4B-3b59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 11 HIS A 144
ALA A 188
HIS A 198
TYR A 239
GLU A 249
MN  A 602 (-3.5A)
None
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
0.43A 4jh4A-3b59A:
7.9
4jh4B-3b59A:
7.8
4jh4A-3b59A:
18.06
4jh4B-3b59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 11 HIS A 198
TYR A 239
GLU A 249
HIS A 144
ALA A 188
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
MN  A 602 (-3.5A)
None
0.41A 4jh5A-3b59A:
7.9
4jh5B-3b59A:
7.7
4jh5A-3b59A:
18.06
4jh5B-3b59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 11 HIS A 144
ALA A 188
HIS A 198
TYR A 239
GLU A 249
MN  A 602 (-3.5A)
None
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
0.44A 4jh5A-3b59A:
7.9
4jh5B-3b59A:
7.7
4jh5A-3b59A:
18.06
4jh5B-3b59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 10 HIS A 198
TYR A 239
GLU A 249
HIS A 144
ALA A 188
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
MN  A 602 (-3.5A)
None
0.44A 4jh6A-3b59A:
8.0
4jh6B-3b59A:
7.9
4jh6A-3b59A:
18.06
4jh6B-3b59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 10 HIS A 144
ALA A 188
HIS A 198
TYR A 239
GLU A 249
MN  A 602 (-3.5A)
None
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
0.45A 4jh6A-3b59A:
8.0
4jh6B-3b59A:
7.9
4jh6A-3b59A:
18.06
4jh6B-3b59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 10 HIS A 198
TYR A 239
GLU A 249
HIS A 144
ALA A 188
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
MN  A 602 (-3.5A)
None
0.43A 4jh8A-3b59A:
7.9
4jh8B-3b59A:
7.8
4jh8A-3b59A:
18.06
4jh8B-3b59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 10 HIS A 144
ALA A 188
HIS A 198
TYR A 239
GLU A 249
MN  A 602 (-3.5A)
None
MN  A 602 (-3.3A)
MN  A 602 (-4.6A)
MN  A 602 (-2.6A)
0.43A 4jh8A-3b59A:
7.9
4jh8B-3b59A:
7.8
4jh8A-3b59A:
18.06
4jh8B-3b59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 12 ALA A 188
LEU A 147
ASN A 197
ILE A   9
ILE A  68
None
1.00A 4o2bB-3b59A:
undetectable
4o2bB-3b59A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 12 ALA A 188
LEU A 147
ASN A 197
ILE A   9
ILE A  68
None
1.01A 5itzB-3b59A:
undetectable
5itzB-3b59A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 12 GLU A 303
ASP A  66
GLY A  15
ASN A  63
ALA A  21
None
1.38A 5kbwA-3b59A:
undetectable
5kbwA-3b59A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
5 / 12 ALA A 188
LEU A 147
ASN A 197
ILE A   9
ILE A  68
None
0.97A 5mioB-3b59A:
undetectable
5mioB-3b59A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
4 / 5 HIS A 184
MET A 175
VAL A 266
LEU A 171
None
1.40A 5xdhB-3b59A:
undetectable
5xdhB-3b59A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
4 / 6 HIS A 184
MET A 175
VAL A 266
LEU A 171
None
1.36A 5xdhA-3b59A:
undetectable
5xdhC-3b59A:
undetectable
5xdhA-3b59A:
14.86
5xdhC-3b59A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans)
4 / 5 HIS A 184
MET A 175
VAL A 266
LEU A 171
None
1.30A 5xdhD-3b59A:
undetectable
5xdhD-3b59A:
14.86