SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 12 VAL A 272
ALA A 333
LEU A 254
PHE A 243
PHE A 344
None
1.06A 1nw3A-3b5iA:
4.5
1nw3A-3b5iA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
3 / 3 ASP A 235
PHE A 365
ASN A 361
None
0.75A 1sg9B-3b5iA:
7.4
1sg9B-3b5iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
3 / 3 PRO A 167
SER A 169
ASN A 269
None
None
MG  A 601 (-3.2A)
0.85A 3lslG-3b5iA:
undetectable
3lslG-3b5iA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
4 / 6 LEU A 145
GLU A 214
PRO A 147
ARG A 211
None
1.40A 3ltwA-3b5iA:
undetectable
3ltwA-3b5iA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
4 / 7 ARG A 324
GLY A 328
VAL A 331
SER A 340
None
0.81A 4a3uB-3b5iA:
undetectable
4a3uB-3b5iA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
3 / 3 ARG A 350
HIS A 246
SER A 349
None
1.03A 4mjwA-3b5iA:
undetectable
4mjwB-3b5iA:
undetectable
4mjwA-3b5iA:
22.30
4mjwB-3b5iA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
3 / 3 SER A 349
ARG A 350
HIS A 246
None
0.98A 4mjwA-3b5iA:
undetectable
4mjwB-3b5iA:
undetectable
4mjwA-3b5iA:
22.30
4mjwB-3b5iA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.48A 4qvmV-3b5iA:
undetectable
4qvmb-3b5iA:
undetectable
4qvmV-3b5iA:
20.74
4qvmb-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.48A 4qvpV-3b5iA:
undetectable
4qvpb-3b5iA:
undetectable
4qvpV-3b5iA:
20.74
4qvpb-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.47A 4qvpH-3b5iA:
undetectable
4qvpN-3b5iA:
undetectable
4qvpH-3b5iA:
20.74
4qvpN-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 10 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.48A 4qvvV-3b5iA:
undetectable
4qvvb-3b5iA:
undetectable
4qvvV-3b5iA:
20.74
4qvvb-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 10 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.49A 4qvvH-3b5iA:
0.3
4qvvN-3b5iA:
undetectable
4qvvH-3b5iA:
20.74
4qvvN-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.47A 4qvyV-3b5iA:
undetectable
4qvyb-3b5iA:
undetectable
4qvyV-3b5iA:
20.74
4qvyb-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.47A 4qvyH-3b5iA:
0.0
4qvyN-3b5iA:
undetectable
4qvyH-3b5iA:
20.74
4qvyN-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.49A 4qw1V-3b5iA:
undetectable
4qw1b-3b5iA:
undetectable
4qw1V-3b5iA:
20.74
4qw1b-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.48A 4qw1H-3b5iA:
undetectable
4qw1N-3b5iA:
undetectable
4qw1H-3b5iA:
20.74
4qw1N-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.48A 4qwuV-3b5iA:
undetectable
4qwub-3b5iA:
undetectable
4qwuV-3b5iA:
20.74
4qwub-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.48A 4qwuH-3b5iA:
undetectable
4qwuN-3b5iA:
undetectable
4qwuH-3b5iA:
20.74
4qwuN-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 9 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.47A 5cz7V-3b5iA:
undetectable
5cz7b-3b5iA:
0.0
5cz7V-3b5iA:
20.74
5cz7b-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.49A 5d0xH-3b5iA:
undetectable
5d0xN-3b5iA:
undetectable
5d0xH-3b5iA:
20.74
5d0xN-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
4 / 5 VAL A  57
VAL A 137
GLY A 136
PHE A 146
None
0.93A 5d4nA-3b5iA:
undetectable
5d4nC-3b5iA:
undetectable
5d4nA-3b5iA:
14.48
5d4nC-3b5iA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.46A 5l5fV-3b5iA:
0.0
5l5fb-3b5iA:
undetectable
5l5fV-3b5iA:
20.74
5l5fb-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.46A 5l5fH-3b5iA:
undetectable
5l5fN-3b5iA:
undetectable
5l5fH-3b5iA:
20.74
5l5fN-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.47A 5l66V-3b5iA:
undetectable
5l66b-3b5iA:
undetectable
5l66V-3b5iA:
20.74
5l66b-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 11 SER A 175
THR A 192
THR A 193
THR A 194
ARG A 180
None
1.48A 5l66H-3b5iA:
undetectable
5l66N-3b5iA:
undetectable
5l66H-3b5iA:
20.74
5l66N-3b5iA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
5 / 12 ILE A 270
GLY A 267
PHE A 268
ALA A 177
ASP A 249
None
1.10A 5x66A-3b5iA:
undetectable
5x66B-3b5iA:
undetectable
5x66A-3b5iA:
20.92
5x66B-3b5iA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
4 / 8 LEU A 160
GLY A 139
ARG A 143
TYR A 142
None
None
None
SAH  A 401 (-4.2A)
0.84A 6ce2A-3b5iA:
undetectable
6ce2A-3b5iA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana)
3 / 3 LYS A 191
SER A 169
SER A 175
None
1.08A 6gbfA-3b5iA:
undetectable
6gbfA-3b5iA:
23.09