SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 3b5n PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1
(Saccharomyces
cerevisiae) 		5 / 12 MET C 482
ALA C 489
ASP C 490
GLY A  73
LEU D 640
 None
 1.08A 2jfaB-3b5nC:
undetectable		 2jfaB-3b5nC:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3b5n PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  52
GLU D 630
ASN D 627
 None
 0.89A 3lp9B-3b5nA:
undetectable
3lp9D-3b5nA:
undetectable		 3lp9B-3b5nA:
13.95
3lp9D-3b5nA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3b5n PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  26
THR A  29
ILE D 594
 None
 0.91A 4e0fB-3b5nA:
undetectable		 4e0fB-3b5nA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3b5n PROTEIN TRANSPORT
PROTEIN SEC9
(Saccharomyces
cerevisiae) 		4 / 5 ASN D 639
ARG D 646
MET D 642
HIS D 641
 None
 1.36A 4g5jA-3b5nD:
undetectable		 4g5jA-3b5nD:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3b5n PROTEIN SSO1
PROTEIN TRANSPORT
PROTEIN SEC9
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 LEU B 200
LEU B 203
GLU B 204
ILE D 601
 None
 0.82A 4ww7A-3b5nB:
undetectable		 4ww7A-3b5nB:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3b5n PROTEIN SSO1
PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 7 THR A  29
LEU A  32
LEU B 203
THR C 444
 None
 0.75A 4z90A-3b5nA:
undetectable
4z90B-3b5nA:
undetectable
4z90C-3b5nA:
undetectable
4z90D-3b5nA:
undetectable
4z90E-3b5nA:
undetectable		 4z90A-3b5nA:
10.40
4z90B-3b5nA:
10.40
4z90C-3b5nA:
10.40
4z90D-3b5nA:
10.40
4z90E-3b5nA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3b5n PROTEIN SSO1
PROTEIN TRANSPORT
PROTEIN SEC9
PROTEIN TRANSPORT
PROTEIN SEC9
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ALA C 457
LEU B 220
ALA D 612
ASP B 216
LEU B 213
 None
 1.05A 5c0oE-3b5nC:
undetectable		 5c0oE-3b5nC:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3b5n SYNAPTOBREVIN
HOMOLOG 1
PROTEIN SSO1
PROTEIN TRANSPORT
PROTEIN SEC9
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 LEU C 462
ILE A  36
THR A  39
MET B 207
 None
 1.08A 5ljcA-3b5nC:
undetectable		 5ljcA-3b5nC:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3b5n PROTEIN SSO1
PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 479
VAL C 475
VAL B 235
ILE A  60
 None
 0.78A 5y9mA-3b5nC:
undetectable		 5y9mA-3b5nC:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 3b5n PROTEIN SSO1
PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1
(Saccharomyces
cerevisiae) 		5 / 9 LEU D 619
VAL A  50
PHE B 214
LEU B 213
ILE A  47
 None
 1.10A 6fdyU-3b5nD:
undetectable		 6fdyU-3b5nD:
13.31