SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  99
GLU A 298
ILE A 299
ARG A 160
LEU A 155
 None
 1.22A 1d1gA-3b74A:
undetectable		 1d1gA-3b74A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 195
TYR A 137
ILE A 131
TYR A 109
LEU A 149
 PEE  A 311 (-4.0A)
PEE  A 311 (-3.8A)
PEE  A 311 ( 4.4A)
PEE  A 311 ( 4.8A)
None
 1.13A 1p91B-3b74A:
undetectable		 1p91B-3b74A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 268
GLY A 267
LEU A 254
LEU A 123
LEU A 245
 None
 1.03A 1ya4C-3b74A:
undetectable		 1ya4C-3b74A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOT_A_2PMA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		5 / 10 PHE A  57
TYR A 207
VAL A 150
TRP A  78
TYR A 206
 None
 1.38A 2aotA-3b74A:
0.1		 2aotA-3b74A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 257
PHE A 125
GLY A 267
GLY A 268
 None
 0.74A 2qx6A-3b74A:
undetectable
2qx6B-3b74A:
undetectable		 2qx6A-3b74A:
20.37
2qx6B-3b74A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		3 / 3 SER A 187
TYR A 190
HIS A 191
 None
 0.71A 2r2vD-3b74A:
undetectable		 2r2vD-3b74A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 166
SER A   4
ASP A  50
PRO A 162
 None
 1.48A 3jqaA-3b74A:
undetectable		 3jqaA-3b74A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 166
SER A   4
ASP A  50
PRO A 162
 None
 1.43A 3jqaC-3b74A:
undetectable		 3jqaC-3b74A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 166
SER A   4
ASP A  50
PRO A 162
 None
 1.47A 3jqaD-3b74A:
undetectable		 3jqaD-3b74A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 102
GLU A 126
TYR A 195
 None
PEE  A 311 ( 4.1A)
PEE  A 311 (-4.0A)
 0.95A 3k37B-3b74A:
undetectable		 3k37B-3b74A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  49
LEU A  25
LEU A  33
GLY A  23
LEU A 171
 None
 1.12A 4dm8B-3b74A:
undetectable		 4dm8B-3b74A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 200
VAL A 230
MET A 226
PHE A 223
ILE A 216
 PEE  A 311 ( 4.3A)
None
PEE  A 311 ( 4.6A)
None
None
 1.21A 4j4vA-3b74A:
0.7		 4j4vA-3b74A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 200
VAL A 230
MET A 226
PHE A 223
ILE A 244
 PEE  A 311 ( 4.3A)
None
PEE  A 311 ( 4.6A)
None
None
 1.47A 4j4vD-3b74A:
0.0
4j4vE-3b74A:
undetectable		 4j4vD-3b74A:
19.70
4j4vE-3b74A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 199
TYR A 195
LEU A 128
LEU A 179
 None
PEE  A 311 (-4.0A)
PEE  A 311 (-4.6A)
None
 1.04A 4jtrA-3b74A:
undetectable		 4jtrA-3b74A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  33
CYH A  13
LEU A 171
ASP A  50
 None
 1.17A 5mafA-3b74A:
undetectable		 5mafA-3b74A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3b74 UNCHARACTERIZED
PROTEIN YKL091C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 196
VAL A 199
ILE A 184
VAL A 230
PHE A 214
 PEE  A 311 (-4.8A)
None
PEE  A 311 ( 3.9A)
None
PEE  A 311 ( 4.4A)
 1.42A 6j21A-3b74A:
undetectable		 6j21A-3b74A:
20.13