SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.37A 1v55N-3b7yA:
undetectable
1v55W-3b7yA:
undetectable		 1v55N-3b7yA:
13.39
1v55W-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.36A 2eijN-3b7yA:
undetectable
2eijW-3b7yA:
undetectable		 2eijN-3b7yA:
13.39
2eijW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.50A 2eijN-3b7yA:
undetectable
2eijW-3b7yA:
undetectable		 2eijN-3b7yA:
13.39
2eijW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 7 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.41A 2eikA-3b7yA:
undetectable
2eikJ-3b7yA:
undetectable		 2eikA-3b7yA:
13.39
2eikJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.37A 2eikN-3b7yA:
undetectable
2eikW-3b7yA:
undetectable		 2eikN-3b7yA:
13.39
2eikW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.50A 2eikN-3b7yA:
undetectable
2eikW-3b7yA:
undetectable		 2eikN-3b7yA:
13.39
2eikW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.38A 2eilN-3b7yA:
undetectable
2eilW-3b7yA:
undetectable		 2eilN-3b7yA:
13.39
2eilW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.31A 2eimJ-3b7yA:
undetectable		 2eimJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.36A 2eimW-3b7yA:
undetectable		 2eimW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.34A 2einA-3b7yA:
undetectable
2einJ-3b7yA:
undetectable		 2einA-3b7yA:
13.39
2einJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.49A 2einA-3b7yA:
undetectable
2einJ-3b7yA:
undetectable		 2einA-3b7yA:
13.39
2einJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.27A 2y69C-3b7yA:
undetectable
2y69J-3b7yA:
undetectable		 2y69C-3b7yA:
21.35
2y69J-3b7yA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.33A 2y69P-3b7yA:
undetectable
2y69W-3b7yA:
undetectable		 2y69P-3b7yA:
21.35
2y69W-3b7yA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.32A 3abkA-3b7yA:
undetectable
3abkJ-3b7yA:
undetectable		 3abkA-3b7yA:
13.39
3abkJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.39A 3ablN-3b7yA:
undetectable
3ablW-3b7yA:
undetectable		 3ablN-3b7yA:
13.39
3ablW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.30A 3abmC-3b7yA:
undetectable
3abmJ-3b7yA:
undetectable		 3abmC-3b7yA:
21.35
3abmJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.31A 3abmP-3b7yA:
undetectable
3abmW-3b7yA:
undetectable		 3abmP-3b7yA:
21.35
3abmW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.37A 3abmN-3b7yA:
undetectable
3abmW-3b7yA:
undetectable		 3abmN-3b7yA:
13.39
3abmW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.35A 3ag1J-3b7yA:
undetectable		 3ag1J-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.38A 3ag2J-3b7yA:
undetectable		 3ag2J-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.25A 3ag3C-3b7yA:
undetectable
3ag3J-3b7yA:
undetectable		 3ag3C-3b7yA:
21.35
3ag3J-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.45A 3ag3N-3b7yA:
undetectable
3ag3W-3b7yA:
undetectable		 3ag3N-3b7yA:
13.39
3ag3W-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.41A 3ag4J-3b7yA:
undetectable		 3ag4J-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.39A 3asnN-3b7yA:
undetectable
3asnW-3b7yA:
undetectable		 3asnN-3b7yA:
13.39
3asnW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.35A 3asoN-3b7yA:
undetectable
3asoW-3b7yA:
undetectable		 3asoN-3b7yA:
13.39
3asoW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		3 / 3 GLU A 107
VAL A 106
CYH A 104
 None
 0.98A 3fbxA-3b7yA:
undetectable		 3fbxA-3b7yA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 10 LEU A 244
ARG A 124
THR A 163
TRP A 172
PHE A 189
 None
 1.35A 4driB-3b7yA:
undetectable		 4driB-3b7yA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 6 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.17A 5b1bC-3b7yA:
undetectable
5b1bJ-3b7yA:
undetectable		 5b1bC-3b7yA:
21.35
5b1bJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 7 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.39A 5b1bN-3b7yA:
undetectable
5b1bW-3b7yA:
undetectable		 5b1bN-3b7yA:
13.39
5b1bW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 7 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.47A 5b1bN-3b7yA:
undetectable
5b1bW-3b7yA:
undetectable		 5b1bN-3b7yA:
13.39
5b1bW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 7 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.31A 5b3sN-3b7yA:
undetectable
5b3sW-3b7yA:
undetectable		 5b3sN-3b7yA:
13.39
5b3sW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 7 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.44A 5b3sN-3b7yA:
undetectable
5b3sW-3b7yA:
undetectable		 5b3sN-3b7yA:
13.39
5b3sW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 9 LEU A 244
ARG A 124
THR A 163
TRP A 172
PHE A 189
 None
 1.44A 5gpgB-3b7yA:
undetectable		 5gpgB-3b7yA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 7 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.37A 5iy5N-3b7yA:
undetectable
5iy5W-3b7yA:
undetectable		 5iy5N-3b7yA:
13.39
5iy5W-3b7yA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.27A 5w97J-3b7yA:
undetectable		 5w97J-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.23A 5wauC-3b7yA:
undetectable
5wauJ-3b7yA:
undetectable		 5wauC-3b7yA:
21.35
5wauJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.26A 5wauc-3b7yA:
undetectable
5wauj-3b7yA:
undetectable		 5wauc-3b7yA:
21.35
5wauj-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.30A 5wauJ-3b7yA:
undetectable		 5wauJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.37A 5x1fW-3b7yA:
undetectable		 5x1fW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.28A 5xdqC-3b7yA:
undetectable
5xdqJ-3b7yA:
undetectable		 5xdqC-3b7yA:
21.35
5xdqJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 PHE A 109
PHE A 178
LEU A 187
PHE A 189
 None
 1.30A 5xdqP-3b7yA:
undetectable
5xdqW-3b7yA:
undetectable		 5xdqP-3b7yA:
21.35
5xdqW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.32A 5xdxN-3b7yA:
undetectable
5xdxW-3b7yA:
undetectable		 5xdxN-3b7yA:
13.39
5xdxW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.30A 5z86J-3b7yA:
undetectable		 5z86J-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.38A 5zcoA-3b7yA:
undetectable
5zcoJ-3b7yA:
undetectable		 5zcoA-3b7yA:
13.39
5zcoJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.49A 5zcoA-3b7yA:
undetectable
5zcoJ-3b7yA:
undetectable		 5zcoA-3b7yA:
13.39
5zcoJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.33A 5zcpN-3b7yA:
undetectable
5zcpW-3b7yA:
undetectable		 5zcpN-3b7yA:
13.39
5zcpW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.49A 5zcpN-3b7yA:
undetectable
5zcpW-3b7yA:
undetectable		 5zcpN-3b7yA:
13.39
5zcpW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.36A 5zcqN-3b7yA:
undetectable
5zcqW-3b7yA:
undetectable		 5zcqN-3b7yA:
13.39
5zcqW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 8 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.50A 5zcqN-3b7yA:
undetectable
5zcqW-3b7yA:
undetectable		 5zcqN-3b7yA:
13.39
5zcqW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		5 / 11 LEU A 231
VAL A 206
VAL A 191
ALA A 127
LEU A 246
 None
 1.10A 6h1lB-3b7yA:
undetectable		 6h1lB-3b7yA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.45A 6nknJ-3b7yA:
undetectable		 6nknJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4
(Homo
sapiens) 		4 / 5 ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.30A 6nknW-3b7yA:
undetectable		 6nknW-3b7yA:
21.80