SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 138
ALA A 145
HIS A  91
ILE A 142
GLY A  94
 None
 1.15A 1c9sN-3b8iA:
undetectable
1c9sO-3b8iA:
undetectable		 1c9sN-3b8iA:
13.45
1c9sO-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 138
ALA A 145
HIS A  91
ILE A 142
GLY A  94
 None
 1.15A 1c9sP-3b8iA:
undetectable
1c9sQ-3b8iA:
undetectable		 1c9sP-3b8iA:
13.45
1c9sQ-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 138
ALA A 145
HIS A  91
ILE A 142
GLY A  94
 None
 1.13A 1c9sQ-3b8iA:
undetectable
1c9sR-3b8iA:
undetectable		 1c9sQ-3b8iA:
13.45
1c9sR-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.16A 1c9sL-3b8iA:
undetectable
1c9sV-3b8iA:
undetectable		 1c9sL-3b8iA:
13.45
1c9sV-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.14A 1gtfJ-3b8iA:
undetectable
1gtfK-3b8iA:
undetectable		 1gtfJ-3b8iA:
13.45
1gtfK-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 138
ALA A 145
HIS A  91
ILE A 142
GLY A  94
 None
 1.20A 1gtfR-3b8iA:
undetectable
1gtfS-3b8iA:
undetectable		 1gtfR-3b8iA:
13.45
1gtfS-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 9 CYH A  44
LEU A   9
ILE A 111
THR A  25
ILE A  46
 None
 1.16A 1hzeA-3b8iA:
undetectable
1hzeB-3b8iA:
undetectable		 1hzeA-3b8iA:
17.07
1hzeB-3b8iA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 9 THR A  25
ILE A  46
CYH A  44
LEU A   9
ILE A 111
 None
 1.16A 1hzeA-3b8iA:
undetectable
1hzeB-3b8iA:
undetectable		 1hzeA-3b8iA:
17.07
1hzeB-3b8iA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 167
LEU A 196
THR A 160
ILE A 185
LEU A 203
 None
 1.12A 1qzfA-3b8iA:
undetectable		 1qzfA-3b8iA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 167
LEU A 196
THR A 160
ILE A 185
LEU A 203
 None
 1.12A 1qzfB-3b8iA:
undetectable		 1qzfB-3b8iA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 167
LEU A 196
THR A 160
ILE A 185
LEU A 203
 None
 1.12A 1qzfC-3b8iA:
undetectable		 1qzfC-3b8iA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 167
LEU A 196
THR A 160
ILE A 185
LEU A 203
 None
 1.12A 1qzfD-3b8iA:
undetectable		 1qzfD-3b8iA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 167
LEU A 196
THR A 160
ILE A 185
LEU A 203
 None
 1.12A 1qzfE-3b8iA:
undetectable		 1qzfE-3b8iA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 138
ALA A 145
HIS A  91
ILE A 142
GLY A  94
 None
 1.14A 1utdE-3b8iA:
undetectable
1utdF-3b8iA:
undetectable		 1utdE-3b8iA:
13.45
1utdF-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 138
ALA A 145
HIS A  91
ILE A 142
GLY A  94
 None
 1.15A 1utdH-3b8iA:
undetectable
1utdI-3b8iA:
undetectable		 1utdH-3b8iA:
13.45
1utdI-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  70
ALA A  74
ARG A  76
LEU A  47
 None
 1.15A 2bxkA-3b8iA:
undetectable		 2bxkA-3b8iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 108
VAL A 103
LEU A 114
ALA A 109
 None
 1.06A 2e1qC-3b8iA:
undetectable		 2e1qC-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 202
ILE A 199
LEU A 226
 None
 0.74A 2kceA-3b8iA:
undetectable		 2kceA-3b8iA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 156
ILE A  86
ILE A 205
ALA A  89
 None
 0.69A 2nniA-3b8iA:
undetectable		 2nniA-3b8iA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 154
ALA A 112
LEU A 106
LEU A  47
THR A  25
 None
 1.39A 2oaxF-3b8iA:
undetectable		 2oaxF-3b8iA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 222
TYR A  23
ASN A 233
 None
 0.72A 4ffwB-3b8iA:
undetectable		 4ffwB-3b8iA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 239
SER A  27
SER A  50
TYR A 238
 None
None
OXL  A 288 (-2.5A)
None
 1.17A 4lv9A-3b8iA:
4.2
4lv9B-3b8iA:
5.6		 4lv9A-3b8iA:
20.79
4lv9B-3b8iA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 238
PHE A 239
SER A  27
SER A  50
 None
None
None
OXL  A 288 (-2.5A)
 1.16A 4lv9A-3b8iA:
4.1
4lv9B-3b8iA:
5.4		 4lv9A-3b8iA:
20.79
4lv9B-3b8iA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  47
GLY A  48
ILE A  65
GLN A  73
 None
OXL  A 288 ( 3.7A)
None
None
 1.15A 4ma8C-3b8iA:
undetectable		 4ma8C-3b8iA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 143
GLY A 140
TYR A 177
GLY A 138
 None
 0.89A 4rdxA-3b8iA:
undetectable		 4rdxA-3b8iA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 260
PRO A 272
PHE A 271
GLU A 274
 None
 1.29A 5b8iA-3b8iA:
undetectable		 5b8iA-3b8iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.17A 5eevA-3b8iA:
undetectable
5eevB-3b8iA:
undetectable		 5eevA-3b8iA:
13.45
5eevB-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.17A 5eewA-3b8iA:
undetectable
5eewB-3b8iA:
undetectable		 5eewA-3b8iA:
13.45
5eewB-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.17A 5eexA-3b8iA:
undetectable
5eexB-3b8iA:
undetectable		 5eexA-3b8iA:
13.45
5eexB-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.17A 5eeyA-3b8iA:
undetectable
5eeyB-3b8iA:
undetectable		 5eeyA-3b8iA:
13.45
5eeyB-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.17A 5eezA-3b8iA:
undetectable
5eezB-3b8iA:
undetectable		 5eezA-3b8iA:
13.45
5eezB-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.17A 5ef0A-3b8iA:
undetectable
5ef0B-3b8iA:
undetectable		 5ef0A-3b8iA:
13.45
5ef0B-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.17A 5ef1A-3b8iA:
undetectable
5ef1B-3b8iA:
undetectable		 5ef1A-3b8iA:
13.45
5ef1B-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.17A 5ef2A-3b8iA:
undetectable
5ef2B-3b8iA:
undetectable		 5ef2A-3b8iA:
13.45
5ef2B-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  94
GLY A 138
ALA A 145
HIS A  91
ILE A 142
 None
 1.17A 5ef3A-3b8iA:
undetectable
5ef3B-3b8iA:
undetectable		 5ef3A-3b8iA:
13.45
5ef3B-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 167
LEU A 217
HIS A 195
ALA A 198
ARG A 173
 None
None
None
None
GOL  A 291 (-4.2A)
 1.33A 5syfB-3b8iA:
3.4		 5syfB-3b8iA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3b8i PA4872 OXALOACETATE
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 210
THR A 115
LEU A  64
ALA A  63
TYR A 275
 None
 1.18A 6djzA-3b8iA:
undetectable		 6djzA-3b8iA:
23.15