SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.82A 1dvxA-3b8kA:
undetectable		 1dvxA-3b8kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.80A 1dvxB-3b8kA:
undetectable		 1dvxB-3b8kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 6 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.58A 1ictB-3b8kA:
undetectable		 1ictB-3b8kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 323
GLY A 325
ILE A 342
ARG A 343
ASN A 341
 None
 1.17A 2vdvE-3b8kA:
undetectable		 2vdvE-3b8kA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 11 GLY A 323
GLY A 325
ILE A 342
ARG A 343
ASN A 341
 None
 1.16A 2vdvF-3b8kA:
undetectable		 2vdvF-3b8kA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 6 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.92A 3cfqA-3b8kA:
undetectable		 3cfqA-3b8kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.88A 3cfqA-3b8kA:
undetectable
3cfqB-3b8kA:
undetectable		 3cfqA-3b8kA:
21.55
3cfqB-3b8kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 SER A 363
LEU A 482
ALA A 503
SER A 527
 None
 0.92A 3cfqA-3b8kA:
undetectable
3cfqB-3b8kA:
undetectable		 3cfqA-3b8kA:
21.55
3cfqB-3b8kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 323
GLY A 325
ILE A 342
ARG A 343
ASN A 341
 None
 1.13A 3ckkA-3b8kA:
undetectable		 3ckkA-3b8kA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.85A 3d2tA-3b8kA:
undetectable		 3d2tA-3b8kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 6 ALA A 503
ILE A 504
VAL A 427
ASN A 481
 None
 1.19A 3nneG-3b8kA:
undetectable		 3nneG-3b8kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 6 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.76A 4d7bB-3b8kA:
undetectable		 4d7bB-3b8kA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 6 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.84A 4i89A-3b8kA:
undetectable		 4i89A-3b8kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 430
ALA A 428
VAL A 427
 None
 0.60A 4o2bA-3b8kA:
undetectable		 4o2bA-3b8kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 430
ALA A 428
VAL A 427
 None
 0.52A 4o2bC-3b8kA:
undetectable		 4o2bC-3b8kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 7 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.75A 4pwjB-3b8kA:
undetectable		 4pwjB-3b8kA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 4 ILE A 479
ASN A 481
ILE A 487
VAL A 528
 None
 1.26A 4uy87-3b8kA:
undetectable		 4uy87-3b8kA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 430
ALA A 428
VAL A 427
 None
 0.60A 4x1iA-3b8kA:
undetectable		 4x1iA-3b8kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 430
ALA A 428
VAL A 427
 None
 0.52A 4x20C-3b8kA:
undetectable		 4x20C-3b8kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 6 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.84A 5bojA-3b8kA:
undetectable		 5bojA-3b8kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 430
ALA A 428
VAL A 427
 None
 0.58A 5eypA-3b8kA:
undetectable		 5eypA-3b8kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 5 ILE A 493
CYH A 500
LEU A 530
HIS A 359
 None
 1.50A 5hrqC-3b8kA:
undetectable
5hrqD-3b8kA:
undetectable
5hrqL-3b8kA:
undetectable		 5hrqC-3b8kA:
5.51
5hrqD-3b8kA:
8.44
5hrqL-3b8kA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		4 / 6 LEU A 482
ALA A 503
SER A 527
THR A 529
 None
 0.90A 5l4iA-3b8kA:
undetectable		 5l4iA-3b8kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
(Homo
sapiens) 		3 / 3 THR A 476
HIS A 421
ASN A 409
 None
 0.99A 5n4tA-3b8kA:
undetectable		 5n4tA-3b8kA:
25.09