SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 LEU A 140
ALA A 143
VAL A  64
TYR A 112
 None
GOL  A 146 ( 4.6A)
GOL  A 146 ( 4.8A)
GOL  A 145 (-4.4A)
 0.83A 1epbA-3b8lA:
undetectable		 1epbA-3b8lA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 GLY A  85
ASP A   7
GLY A 122
THR A 126
 None
 0.92A 1hxbB-3b8lA:
undetectable		 1hxbB-3b8lA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 10 HIS A  71
ALA A  66
PHE A  65
GLY A  56
PHE A  60
 GOL  A 146 (-4.0A)
None
None
None
None
 1.29A 1uhoA-3b8lA:
undetectable		 1uhoA-3b8lA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 11 GLY A  98
ALA A 143
PHE A  60
LEU A 140
VAL A  22
 GOL  A 146 ( 4.4A)
GOL  A 146 ( 4.6A)
None
None
None
 1.11A 1ukbA-3b8lA:
undetectable		 1ukbA-3b8lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 LEU A  14
GLY A  85
ALA A  10
ILE A  11
 None
 0.84A 2aohB-3b8lA:
undetectable		 2aohB-3b8lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 TYR A 112
MET A 130
THR A 129
LEU A  43
 GOL  A 145 (-4.4A)
GOL  A 145 ( 3.8A)
None
None
 1.25A 2eimJ-3b8lA:
undetectable		 2eimJ-3b8lA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 TYR A 112
MET A 130
THR A 129
LEU A  43
 GOL  A 145 (-4.4A)
GOL  A 145 ( 3.8A)
None
None
 1.28A 2eimW-3b8lA:
undetectable		 2eimW-3b8lA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 6 THR A 119
ARG A 117
THR A  36
ASP A  27
 None
 1.30A 2okcA-3b8lA:
undetectable		 2okcA-3b8lA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 ALA A 125
TYR A  18
ALA A  39
TYR A 128
 None
GOL  A 145 (-4.7A)
None
GOL  A 145 (-4.7A)
 1.24A 2wlkA-3b8lA:
undetectable
2wlkB-3b8lA:
undetectable		 2wlkA-3b8lA:
18.58
2wlkB-3b8lA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 TYR A 112
MET A 130
THR A 129
LEU A  43
 GOL  A 145 (-4.4A)
GOL  A 145 ( 3.8A)
None
None
 1.27A 3ag2J-3b8lA:
undetectable		 3ag2J-3b8lA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 TYR A 112
MET A 130
THR A 129
LEU A  43
 GOL  A 145 (-4.4A)
GOL  A 145 ( 3.8A)
None
None
 1.26A 3ag4J-3b8lA:
undetectable		 3ag4J-3b8lA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 VAL A  94
ASP A  23
LEU A  75
ILE A  46
 None
 0.91A 3avpA-3b8lA:
undetectable		 3avpA-3b8lA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 4 GLY A  85
ASP A   7
GLY A 122
THR A 126
 None
 0.91A 3k4vC-3b8lA:
undetectable		 3k4vC-3b8lA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 ARG A 117
LEU A  14
ILE A  57
PHE A  35
 None
 1.03A 3ln1C-3b8lA:
undetectable		 3ln1C-3b8lA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 ARG A 117
LEU A  14
ILE A  57
PHE A  35
 None
 1.04A 3ln1D-3b8lA:
undetectable		 3ln1D-3b8lA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 PHE A  41
TYR A 128
PHE A 114
ILE A  57
 None
GOL  A 145 (-4.7A)
None
None
 1.26A 4jx1E-3b8lA:
undetectable		 4jx1E-3b8lA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 ARG A   8
ILE A  11
PRO A   4
ILE A   5
 None
 1.01A 4w5oA-3b8lA:
undetectable		 4w5oA-3b8lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 ARG A   8
ILE A  11
PRO A   4
ILE A   5
 None
 1.00A 4z4eA-3b8lA:
undetectable		 4z4eA-3b8lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 7 ARG A   8
ILE A  11
PRO A   4
ILE A   5
 None
 1.00A 4z4gA-3b8lA:
undetectable		 4z4gA-3b8lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 ASN A  63
ASP A 102
GLY A 100
 None
 0.68A 5fctB-3b8lA:
undetectable		 5fctB-3b8lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A  46
LEU A  43
GLY A 110
GLY A  96
TYR A 112
 None
None
None
GOL  A 146 (-4.0A)
GOL  A 145 (-4.4A)
 1.24A 5nnaA-3b8lA:
undetectable		 5nnaA-3b8lA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A  46
LEU A  43
GLY A 110
GLY A  96
TYR A 112
 None
None
None
GOL  A 146 (-4.0A)
GOL  A 145 (-4.4A)
 1.23A 5nnaD-3b8lA:
undetectable		 5nnaD-3b8lA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 TYR A 112
MET A 130
THR A 129
LEU A  43
 GOL  A 145 (-4.4A)
GOL  A 145 ( 3.8A)
None
None
 1.22A 5wauJ-3b8lA:
undetectable		 5wauJ-3b8lA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		4 / 5 TYR A 112
MET A 130
THR A 129
LEU A  43
 GOL  A 145 (-4.4A)
GOL  A 145 ( 3.8A)
None
None
 1.27A 5z86J-3b8lA:
undetectable		 5z86J-3b8lA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3b8l UNCHARACTERIZED
PROTEIN
(Novosphingobium
aromaticivorans) 		3 / 3 LEU A 136
GLY A  47
PHE A  60
 None
 0.65A 6exiC-3b8lA:
undetectable		 6exiC-3b8lA:
17.79