SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 7 PHE A 154
ARG A  64
TYR A 102
ILE A  61
 None
 0.86A 1oniA-3b8oA:
undetectable
1oniB-3b8oA:
undetectable		 1oniA-3b8oA:
20.46
1oniB-3b8oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 7 TYR A 102
ILE A  61
PHE A 154
ARG A  64
 None
 1.03A 1oniD-3b8oA:
undetectable
1oniE-3b8oA:
undetectable		 1oniD-3b8oA:
20.46
1oniE-3b8oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 6 PHE A 154
ARG A  64
TYR A 102
ILE A  61
 None
 0.89A 1oniH-3b8oA:
undetectable
1oniI-3b8oA:
undetectable		 1oniH-3b8oA:
20.46
1oniI-3b8oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 7 TYR A 102
ILE A  61
PHE A 154
ARG A  64
 None
 0.77A 1oniG-3b8oA:
undetectable
1oniI-3b8oA:
undetectable		 1oniG-3b8oA:
20.46
1oniI-3b8oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 4 VAL A 180
TYR A 179
VAL A 162
SER A  58
 None
 1.42A 2x45B-3b8oA:
undetectable		 2x45B-3b8oA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 7 TRP A 119
SER A  58
GLN A 178
ILE A 147
 None
 1.15A 2xz5A-3b8oA:
undetectable
2xz5B-3b8oA:
undetectable		 2xz5A-3b8oA:
19.34
2xz5B-3b8oA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 8 TYR A 124
SER A  58
GLN A 178
ILE A 147
 None
 0.88A 2xz5B-3b8oA:
undetectable
2xz5E-3b8oA:
undetectable		 2xz5B-3b8oA:
19.34
2xz5E-3b8oA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 7 GLN A 178
ILE A 147
TYR A 124
TRP A 119
 None
 1.15A 2xz5D-3b8oA:
undetectable
2xz5E-3b8oA:
undetectable		 2xz5D-3b8oA:
19.34
2xz5E-3b8oA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 4 LEU A 109
LEU A 164
GLN A 185
GLU A 117
 None
 1.18A 4i41A-3b8oA:
undetectable		 4i41A-3b8oA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		5 / 12 VAL A 180
ALA A 181
TYR A 179
PHE A 105
THR A  62
 None
 1.34A 4mm4A-3b8oA:
undetectable		 4mm4A-3b8oA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE
(Escherichia
coli) 		4 / 5 ARG A 128
THR A 168
ALA A 166
ASP A 171
 None
 1.33A 5mfxA-3b8oA:
undetectable		 5mfxA-3b8oA:
20.62