SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b97'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 11 LEU A 258
PHE A 250
VAL A 288
LEU A 223
LEU A 275
 None
 1.07A 1mx1B-3b97A:
undetectable		 1mx1B-3b97A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		4 / 4 SER A 114
VAL A  21
PHE A 379
VAL A 343
 None
 1.41A 1o86A-3b97A:
undetectable		 1o86A-3b97A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		4 / 7 TYR A 406
ILE A 169
PRO A 171
ALA A 180
 None
 1.00A 1oniD-3b97A:
undetectable
1oniE-3b97A:
undetectable		 1oniD-3b97A:
20.62
1oniE-3b97A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 10 GLN A 313
MET A 367
VAL A 289
LEU A 170
VAL A 239
 None
 1.45A 2c12D-3b97A:
0.0		 2c12D-3b97A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		3 / 3 ILE A 183
ILE A 230
LEU A 403
 None
 0.53A 2prgA-3b97A:
undetectable		 2prgA-3b97A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		4 / 7 LEU A 170
LEU A 162
LEU A 226
LEU A 275
 None
 0.89A 3g8iA-3b97A:
undetectable		 3g8iA-3b97A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		4 / 7 VAL A  21
ILE A  89
THR A 350
GLY A 112
 None
 0.99A 3gssA-3b97A:
undetectable		 3gssA-3b97A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		4 / 5 GLU A  85
GLN A  86
HIS A 132
GLY A 121
 None
 1.13A 3pp1A-3b97A:
undetectable		 3pp1A-3b97A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 10 THR A 204
ASN A 205
GLY A 159
GLY A 200
ALA A 203
 None
 1.44A 3pp7B-3b97A:
6.6		 3pp7B-3b97A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 12 LEU A 339
LEU A 340
ILE A 380
ILE A 392
LEU A 387
 None
 1.23A 4j24C-3b97A:
undetectable		 4j24C-3b97A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 12 LEU A 339
LEU A 340
ILE A 380
ILE A 392
LEU A 387
 None
 1.16A 4j26B-3b97A:
undetectable		 4j26B-3b97A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		4 / 8 ARG A 402
ASP A 208
ALA A  38
SER A  39
 None
None
SO4  A 436 (-3.7A)
MG  A 435 ( 2.3A)
 1.01A 4lv9A-3b97A:
2.5
4lv9B-3b97A:
2.9		 4lv9A-3b97A:
25.82
4lv9B-3b97A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		4 / 4 PHE A 250
VAL A 245
ALA A 163
PHE A 167
 None
 1.48A 4w5qA-3b97A:
undetectable		 4w5qA-3b97A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 12 ALA A  32
ASP A 377
LEU A  23
HIS A 132
LEU A 129
 None
 1.13A 4xi3A-3b97A:
undetectable		 4xi3A-3b97A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		4 / 6 PHE A 260
LEU A 162
ASN A 215
ARG A 252
 None
 1.16A 4yv5B-3b97A:
undetectable		 4yv5B-3b97A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		4 / 6 PHE A 260
LEU A 162
ASN A 215
ARG A 252
 None
 1.18A 4yv5A-3b97A:
undetectable		 4yv5A-3b97A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 9 ASN A 150
HIS A 157
GLY A 154
GLY A 155
ASP A 208
 None
SO4  A 436 (-4.1A)
None
None
None
 1.41A 5f8yA-3b97A:
undetectable		 5f8yA-3b97A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 9 HIS A 157
GLY A 154
GLY A 155
ASP A 208
ASN A 150
 SO4  A 436 (-4.1A)
None
None
None
None
 1.43A 5f8yA-3b97A:
undetectable		 5f8yA-3b97A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 9 HIS A 157
GLY A 154
GLY A 155
ASP A 208
ASN A 150
 SO4  A 436 (-4.1A)
None
None
None
None
 1.43A 5f8yB-3b97A:
undetectable		 5f8yB-3b97A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 9 ASN A 150
HIS A 157
GLY A 154
GLY A 155
ASP A 208
 None
SO4  A 436 (-4.1A)
None
None
None
 1.41A 5f8yB-3b97A:
undetectable		 5f8yB-3b97A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		5 / 12 VAL A 245
LEU A 170
ARG A 428
GLY A 316
LEU A 340
 None
 1.29A 5ogcB-3b97A:
undetectable		 5ogcB-3b97A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		4 / 8 LYS A 119
ALA A 120
VAL A 123
GLY A  28
 None
 0.88A 5v0vA-3b97A:
undetectable		 5v0vA-3b97A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 3b97 ALPHA-ENOLASE
(Homo
sapiens) 		3 / 3 ALA A 174
VAL A 187
TYR A 235
 None
 0.69A 5zmqH-3b97A:
undetectable		 5zmqH-3b97A:
19.25