SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		4 / 6 PRO A  29
ASP A  62
ASP A  78
TYR A 355
 None
 1.48A 1hpkA-3b98A:
undetectable		 1hpkA-3b98A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		3 / 3 ARG A  22
GLY A 360
ASP A 361
 None
 0.57A 1kf6A-3b98A:
undetectable
1kf6B-3b98A:
undetectable		 1kf6A-3b98A:
21.30
1kf6B-3b98A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		3 / 3 PHE A 106
PHE A 200
PHE A 197
 None
 0.88A 2od9A-3b98A:
undetectable		 2od9A-3b98A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		3 / 3 PHE A 106
PHE A 200
PHE A 197
 None
 0.88A 2qqgA-3b98A:
undetectable		 2qqgA-3b98A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		5 / 12 THR A 328
ALA A 282
ALA A 427
GLY A 464
PRO A 413
 None
None
HEM  A 600 ( 3.7A)
None
None
 1.27A 2ve3B-3b98A:
33.0		 2ve3B-3b98A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		5 / 12 ASN A 277
PRO A 280
GLY A 279
LEU A 227
PHE A 180
 HEM  A 600 (-4.1A)
None
None
None
None
 1.49A 3r24A-3b98A:
undetectable		 3r24A-3b98A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		3 / 3 PRO A 205
ILE A 193
SER A 459
 None
 0.80A 5fsaA-3b98A:
30.3		 5fsaA-3b98A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		5 / 10 VAL A 285
LEU A 329
THR A 332
ALA A 333
PRO A 413
 None
None
None
HEM  A 600 ( 4.4A)
None
 1.30A 5tt3A-3b98A:
undetectable		 5tt3A-3b98A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		5 / 10 VAL A 285
LEU A 329
THR A 332
ALA A 333
PRO A 413
 None
None
None
HEM  A 600 ( 4.4A)
None
 1.25A 5tt3C-3b98A:
undetectable		 5tt3C-3b98A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		5 / 12 LEU A 142
THR A 174
GLY A 175
PRO A 280
ILE A 438
 None
 1.18A 5tuiB-3b98A:
undetectable		 5tuiB-3b98A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		4 / 4 PHE A 442
LEU A 171
LEU A 166
VAL A 435
 None
 1.37A 5xxiA-3b98A:
29.6		 5xxiA-3b98A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3b98 PROSTAGLANDIN I2
SYNTHASE
(Danio
rerio) 		4 / 7 LEU A 466
ALA A  49
ALA A  50
THR A  54
 None
 0.84A 6a7jA-3b98A:
26.4		 6a7jA-3b98A:
10.89