SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bbh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
LEU A  63
LEU A  88
MET A 107
LEU A  12
 None
 1.16A 1sqnB-3bbhA:
undetectable		 1sqnB-3bbhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  14
ILE A  80
THR A  82
LYS A  86
LEU A  88
 None
 0.90A 1tw4A-3bbhA:
undetectable		 1tw4A-3bbhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 138
ILE A 160
LEU A 126
THR A 125
LEU A 129
 None
 0.98A 2bdmA-3bbhA:
undetectable		 2bdmA-3bbhA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 130
ILE A 171
ILE A 138
ILE A 140
 None
 0.66A 2bu8A-3bbhA:
undetectable		 2bu8A-3bbhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  57
ILE A  80
THR A  82
LYS A  86
LEU A  88
 None
 0.99A 2qo5A-3bbhA:
undetectable		 2qo5A-3bbhA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A  12
ILE A  33
TYR A 100
ARG A  54
 None
 0.96A 3b9lA-3bbhA:
undetectable		 3b9lA-3bbhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A 159
VAL A 176
ILE A 171
 None
 0.61A 4emaA-3bbhA:
undetectable		 4emaA-3bbhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A 129
ALA A 135
VAL A 176
ILE A 183
 None
 0.90A 4eyrA-3bbhA:
undetectable		 4eyrA-3bbhA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 126
THR A 158
ILE A 133
ILE A 171
ILE A 138
 None
None
GOL  A 209 ( 4.7A)
None
None
 1.20A 4rp8C-3bbhA:
undetectable		 4rp8C-3bbhA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  66
LEU A  63
LEU A  88
ILE A 119
LEU A 111
 None
 1.06A 4zowA-3bbhA:
undetectable		 4zowA-3bbhA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 161
GLY A 162
SER A 184
LEU A 190
VAL A 195
 SFG  A 206 ( 4.7A)
SFG  A 206 (-3.2A)
SFG  A 206 (-3.3A)
SFG  A 206 (-4.4A)
SFG  A 206 (-4.8A)
 0.47A 5twjA-3bbhA:
6.2		 5twjA-3bbhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 161
GLY A 162
SER A 184
LEU A 190
VAL A 195
 SFG  A 206 ( 4.7A)
SFG  A 206 (-3.2A)
SFG  A 206 (-3.3A)
SFG  A 206 (-4.4A)
SFG  A 206 (-4.8A)
 0.48A 5twjC-3bbhA:
6.4		 5twjC-3bbhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 138
ILE A 140
LEU A 169
ILE A 133
ASN A  77
 None
None
None
GOL  A 209 ( 4.7A)
GOL  A 209 (-4.6A)
 1.31A 5vkqA-3bbhA:
undetectable
5vkqD-3bbhA:
undetectable		 5vkqA-3bbhA:
7.94
5vkqD-3bbhA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 133
ASN A  77
ILE A 138
ILE A 140
LEU A 169
 GOL  A 209 ( 4.7A)
GOL  A 209 (-4.6A)
None
None
None
 1.29A 5vkqA-3bbhA:
undetectable
5vkqB-3bbhA:
undetectable		 5vkqA-3bbhA:
7.94
5vkqB-3bbhA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 133
ASN A  77
ILE A 138
ILE A 140
LEU A 169
 GOL  A 209 ( 4.7A)
GOL  A 209 (-4.6A)
None
None
None
 1.30A 5vkqC-3bbhA:
undetectable
5vkqD-3bbhA:
undetectable		 5vkqC-3bbhA:
7.94
5vkqD-3bbhA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 185
SER A  61
TRP A 193
ILE A 198
CYH A 196
 SFG  A 206 (-4.5A)
None
None
None
None
 1.24A 6gsdA-3bbhA:
undetectable		 6gsdA-3bbhA:
17.16