SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bbj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		4 / 5 PRO A  72
LEU A  25
THR A  99
ARG A  66
 None
None
None
SO4  A 272 (-4.2A)
 1.24A 1i2wA-3bbjA:
undetectable		 1i2wA-3bbjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		3 / 3 THR A 169
GLU A 172
ASP A 251
 None
 0.78A 1nt2A-3bbjA:
undetectable		 1nt2A-3bbjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		4 / 6 LEU A 101
GLU A 218
LEU A  40
VAL A 198
 None
 1.12A 1sn5A-3bbjA:
undetectable		 1sn5A-3bbjA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		6 / 12 LEU A  25
GLY A  28
GLY A  32
ILE A  31
PRO A  67
ALA A  68
 None
None
CL  A 274 ( 3.7A)
None
None
None
 1.28A 2nmzB-3bbjA:
undetectable		 2nmzB-3bbjA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		3 / 3 ASP A 251
THR A 169
GLU A 172
 None
 0.81A 2zifB-3bbjA:
undetectable		 2zifB-3bbjA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		5 / 10 ASP A  26
TYR A  39
ARG A 149
ALA A 148
GLY A  38
 None
 1.45A 4lb9A-3bbjA:
0.0		 4lb9A-3bbjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		5 / 12 ALA A  68
LEU A  40
GLY A  71
PRO A  72
ALA A  73
 None
 1.10A 4ypmA-3bbjA:
undetectable		 4ypmA-3bbjA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		5 / 9 ALA A  68
GLY A  71
LEU A  25
LEU A  40
GLU A  74
 None
 1.19A 5dqfA-3bbjA:
undetectable		 5dqfA-3bbjA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		3 / 3 ARG A  46
PHE A  94
LEU A  25
 None
 0.77A 5veuA-3bbjA:
undetectable		 5veuA-3bbjA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		4 / 4 VAL A 198
LEU A 252
LEU A 232
ASP A 178
 None
 1.43A 5xv7A-3bbjA:
1.4		 5xv7A-3bbjA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3bbj PUTATIVE
THIOESTERASE II
(Thermobifida
fusca) 		4 / 5 SER A 180
ARG A 182
ASP A 183
ARG A 149
 None
 1.26A 6dwdA-3bbjA:
undetectable		 6dwdA-3bbjA:
21.01