SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 10 ASN A 133
VAL A  20
VAL A  25
GLY A  21
LEU A  97
 GNP  A 195 (-3.2A)
GNP  A 195 ( 4.1A)
None
GNP  A 195 (-3.3A)
None
 1.34A 1fkoA-3bc1A:
undetectable		 1fkoA-3bc1A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		4 / 7 TYR A 122
ILE A 181
PHE A  95
ALA A  92
 None
 1.06A 1oniG-3bc1A:
undetectable
1oniI-3bc1A:
undetectable		 1oniG-3bc1A:
22.50
1oniI-3bc1A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 12 THR A  41
GLY A  21
GLY A  19
GLY A  77
ASP A 136
 MG  A 194 ( 3.1A)
GNP  A 195 (-3.3A)
GNP  A 195 (-3.7A)
GNP  A 195 (-3.7A)
GNP  A 195 (-2.9A)
 1.07A 2b25A-3bc1A:
undetectable		 2b25A-3bc1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 12 ALA A  14
LEU A  15
LEU A  13
ILE A  10
LEU A 177
 None
 1.11A 2jfaA-3bc1A:
undetectable		 2jfaA-3bc1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 12 LEU A  98
ASP A  74
LEU A  26
ILE A 170
THR A  41
 None
MG  A 194 ( 4.0A)
None
None
MG  A 194 ( 3.1A)
 1.20A 3hj3A-3bc1A:
undetectable		 3hj3A-3bc1A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 10 ASN A 133
VAL A  20
VAL A  25
GLY A  21
LEU A  97
 GNP  A 195 (-3.2A)
GNP  A 195 ( 4.1A)
None
GNP  A 195 (-3.3A)
None
 1.43A 3lp1A-3bc1A:
undetectable		 3lp1A-3bc1A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		6 / 12 GLY A  94
ALA A  14
ARG A 184
ILE A  68
TYR A  53
LEU A 178
 None
 1.34A 3mb5A-3bc1A:
undetectable		 3mb5A-3bc1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 12 ILE A 128
VAL A 129
GLY A  94
LEU A  96
LEU A 178
 None
 0.88A 3mb5A-3bc1A:
undetectable		 3mb5A-3bc1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		3 / 3 GLU A 161
LEU A 101
LEU A 108
 None
 0.74A 3ohtA-3bc1A:
undetectable		 3ohtA-3bc1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		3 / 3 GLU A 161
LEU A 101
LEU A 108
 None
 0.70A 3ohtB-3bc1A:
undetectable		 3ohtB-3bc1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		3 / 3 GLY A  19
GLY A  21
THR A  23
 GNP  A 195 (-3.7A)
GNP  A 195 (-3.3A)
MG  A 194 ( 3.1A)
 0.42A 3si7B-3bc1A:
undetectable		 3si7B-3bc1A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		4 / 6 ASP A  17
GLY A  19
VAL A  20
ASP A 100
 None
GNP  A 195 (-3.7A)
GNP  A 195 ( 4.1A)
None
 1.15A 3vqrA-3bc1A:
undetectable		 3vqrA-3bc1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		4 / 5 ASP A  17
GLY A  19
VAL A  20
ASP A 100
 None
GNP  A 195 (-3.7A)
GNP  A 195 ( 4.1A)
None
 1.16A 3vqrB-3bc1A:
undetectable		 3vqrB-3bc1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 11 LEU A 177
LEU A 180
ILE A 181
LEU A 117
ILE A 157
 None
 1.18A 4dm8A-3bc1A:
undetectable		 4dm8A-3bc1A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		3 / 3 ASP A 127
SER A 123
TYR A 122
 None
 0.70A 5glmA-3bc1A:
undetectable		 5glmA-3bc1A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3bc1 RAS-RELATED PROTEIN
RAB-27A
(Mus
musculus) 		5 / 10 VAL A  51
LEU A  70
LEU A  72
LEU A 177
LEU A 178
 None
 0.94A 6f6nA-3bc1A:
undetectable
6f6nB-3bc1A:
undetectable		 6f6nA-3bc1A:
18.82
6f6nB-3bc1A:
18.42