SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bc9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		6 / 12 LEU A 315
ASP A 350
ALA A 351
HIS A 446
ASP A 447
ARG A 450
 None
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
GLC  A 805 (-3.1A)
 1.10A 1dedA-3bc9A:
27.1		 1dedA-3bc9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		6 / 12 TYR A 184
LEU A 315
ASP A 350
ALA A 351
HIS A 446
ASP A 447
 ACI  A 806 ( 4.0A)
None
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.70A 1dedA-3bc9A:
27.1		 1dedA-3bc9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 TYR A 184
ARG A 348
ASP A 350
ALA A 351
GLU A 380
HIS A 446
ARG A 450
 ACI  A 806 ( 4.0A)
ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
GLC  A 805 (-3.1A)
 1.03A 1dedB-3bc9A:
24.4		 1dedB-3bc9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 TYR A 184
ARG A 348
ASP A 350
ALA A 351
GLU A 380
HIS A 446
ASP A 447
 ACI  A 806 ( 4.0A)
ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.71A 1dedB-3bc9A:
24.4		 1dedB-3bc9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 6 GLY A 534
TYR A 503
ALA A 500
TYR A 506
 None
 0.95A 1dmaB-3bc9A:
undetectable		 1dmaB-3bc9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA651_1
(AMYLOMALTASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 TYR A 184
HIS A 354
HIS A 446
ASP A 447
TRP A 131
 ACI  A 806 ( 4.0A)
GLD  A 807 ( 3.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
None
 1.30A 1eswA-3bc9A:
14.8		 1eswA-3bc9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 8 HIS A 567
ALA A 468
ILE A 539
THR A 565
 None
 0.77A 1gtnP-3bc9A:
1.7
1gtnQ-3bc9A:
1.5		 1gtnP-3bc9A:
7.95
1gtnQ-3bc9A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 TRP A 131
GLY A 317
ALA A 351
GLU A 380
ASP A 447
 None
ACI  A 803 (-3.3A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-2.9A)
 0.86A 1kxhA-3bc9A:
27.5		 1kxhA-3bc9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 TRP A 131
HIS A 233
ALA A 351
GLU A 380
ASP A 447
 None
ACI  A 806 (-4.4A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-2.9A)
 0.81A 1kxhA-3bc9A:
27.5		 1kxhA-3bc9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		10 / 12 TRP A 131
TYR A 184
HIS A 233
ARG A 348
ASP A 350
LYS A 353
GLU A 380
TRP A 382
HIS A 446
ASP A 447
 None
ACI  A 806 ( 4.0A)
ACI  A 806 (-4.4A)
ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLC  A 808 (-2.9A)
GLD  A 807 ( 2.8A)
GLC  A 808 (-3.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.43A 1mxdA-3bc9A:
39.8		 1mxdA-3bc9A:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 ALA A 214
ILE A 215
VAL A 167
ALA A 166
PHE A 344
 None
 1.09A 1udtA-3bc9A:
undetectable		 1udtA-3bc9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 10 ALA A 214
ILE A 215
VAL A 167
ALA A 166
PHE A 344
 None
 1.10A 1xp0A-3bc9A:
undetectable		 1xp0A-3bc9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 10 LEU A 211
ILE A 215
VAL A 167
ALA A 166
PHE A 344
 None
 1.10A 1xp0A-3bc9A:
undetectable		 1xp0A-3bc9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		3 / 3 ASP A 283
ASP A 246
ASN A 324
 CA  A 701 ( 2.2A)
None
None
 0.81A 2bm9D-3bc9A:
undetectable		 2bm9D-3bc9A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 ALA A 214
ILE A 215
VAL A 167
ALA A 166
PHE A 344
 None
 1.07A 2h42B-3bc9A:
undetectable		 2h42B-3bc9A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWC_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 11 TYR A 184
ASP A 350
HIS A 446
ASP A 447
TRP A 131
 ACI  A 806 ( 4.0A)
ACI  A 806 (-3.1A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
None
 0.95A 2owcA-3bc9A:
14.1		 2owcA-3bc9A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OWW_A_ACRA600_1
(4-ALPHA-GLUCANOTRANS
FERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 11 TYR A 184
ASP A 350
HIS A 446
ASP A 447
TRP A 131
 ACI  A 806 ( 4.0A)
ACI  A 806 (-3.1A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
None
 0.98A 2owwA-3bc9A:
14.2		 2owwA-3bc9A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		3 / 3 GLN A 197
THR A 186
TRP A 334
 None
 0.88A 2rctA-3bc9A:
undetectable		 2rctA-3bc9A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		6 / 12 ARG A 348
ASP A 350
GLU A 380
ARG A 409
HIS A 446
ASP A 447
 ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 ( 2.8A)
None
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 1.11A 3aicA-3bc9A:
13.6		 3aicA-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 LEU A 315
ARG A 348
ASP A 350
ALA A 351
GLU A 380
HIS A 446
ASP A 447
 None
ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.63A 3aicA-3bc9A:
13.6		 3aicA-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		6 / 12 ARG A 348
ASP A 350
GLU A 380
ARG A 409
HIS A 446
ASP A 447
 ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 ( 2.8A)
None
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 1.16A 3aicB-3bc9A:
13.6		 3aicB-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 LEU A 315
ARG A 348
ASP A 350
ALA A 351
GLU A 380
HIS A 446
ASP A 447
 None
ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.61A 3aicB-3bc9A:
13.6		 3aicB-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 ARG A 348
ASP A 350
ALA A 351
GLU A 380
HIS A 446
ASP A 447
TYR A 184
 ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
ACI  A 806 ( 4.0A)
 0.56A 3aicC-3bc9A:
13.7		 3aicC-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 ARG A 348
ASP A 350
GLU A 380
ARG A 409
HIS A 446
ASP A 447
TYR A 184
 ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 ( 2.8A)
None
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
ACI  A 806 ( 4.0A)
 1.10A 3aicC-3bc9A:
13.7		 3aicC-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		6 / 12 ARG A 348
ASP A 350
GLU A 380
ARG A 409
HIS A 446
ASP A 447
 ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 ( 2.8A)
None
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 1.19A 3aicD-3bc9A:
13.8		 3aicD-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 LEU A 315
ARG A 348
ASP A 350
ALA A 351
GLU A 380
HIS A 446
ASP A 447
 None
ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.65A 3aicD-3bc9A:
13.8		 3aicD-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		6 / 12 ARG A 348
ASP A 350
GLU A 380
ARG A 409
HIS A 446
ASP A 447
 ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 ( 2.8A)
None
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 1.14A 3aicE-3bc9A:
13.8		 3aicE-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 LEU A 315
ARG A 348
ASP A 350
ALA A 351
GLU A 380
HIS A 446
ASP A 447
 None
ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.64A 3aicE-3bc9A:
13.8		 3aicE-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		6 / 12 ARG A 348
ASP A 350
GLU A 380
ARG A 409
HIS A 446
ASP A 447
 ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 ( 2.8A)
None
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 1.15A 3aicF-3bc9A:
13.7		 3aicF-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 LEU A 315
ARG A 348
ASP A 350
ALA A 351
GLU A 380
HIS A 446
ASP A 447
 None
ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.62A 3aicF-3bc9A:
13.7		 3aicF-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		6 / 12 ARG A 348
ASP A 350
GLU A 380
ARG A 409
HIS A 446
ASP A 447
 ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 ( 2.8A)
None
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 1.15A 3aicG-3bc9A:
13.8		 3aicG-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 LEU A 315
ARG A 348
ASP A 350
ALA A 351
GLU A 380
HIS A 446
ASP A 447
 None
ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.60A 3aicG-3bc9A:
13.8		 3aicG-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 ARG A 348
ASP A 350
ALA A 351
GLU A 380
ARG A 409
HIS A 446
ASP A 447
 ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
None
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 1.13A 3aicH-3bc9A:
13.7		 3aicH-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		7 / 12 LEU A 315
ARG A 348
ASP A 350
ALA A 351
GLU A 380
HIS A 446
ASP A 447
 None
ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 (-3.6A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.68A 3aicH-3bc9A:
13.7		 3aicH-3bc9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		3 / 3 GLY A 534
GLY A 507
GLY A 526
 None
None
CA  A 705 ( 4.1A)
 0.42A 3bogC-3bc9A:
undetectable		 3bogC-3bc9A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		3 / 3 GLY A 534
GLY A 507
GLY A 526
 None
None
CA  A 705 ( 4.1A)
 0.38A 3bogD-3bc9A:
undetectable		 3bogD-3bc9A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 8 GLU A 511
TYR A 522
LEU A 537
TYR A 469
 None
 1.13A 3rqwF-3bc9A:
undetectable
3rqwJ-3bc9A:
undetectable		 3rqwF-3bc9A:
21.13
3rqwJ-3bc9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 LEU A  52
PHE A  78
ILE A 104
PRO A  82
VAL A  29
 None
 1.41A 3w1wB-3bc9A:
undetectable		 3w1wB-3bc9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		3 / 3 TYR A 455
ARG A 450
SER A 454
 GLD  A 807 (-3.7A)
GLC  A 805 (-3.1A)
None
 0.95A 4dr2I-3bc9A:
undetectable
4dr2J-3bc9A:
undetectable		 4dr2I-3bc9A:
12.79
4dr2J-3bc9A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 6 GLY A 476
VAL A 430
GLY A 509
GLU A 511
 None
 0.89A 4dxuA-3bc9A:
undetectable		 4dxuA-3bc9A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 11 GLY A 428
ASN A 431
ARG A 425
VAL A 430
PHE A 412
 None
 1.21A 4j4vA-3bc9A:
undetectable		 4j4vA-3bc9A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 10 GLY A 428
ASN A 431
ARG A 425
VAL A 430
PHE A 412
 None
 1.21A 4j4vA-3bc9A:
undetectable
4j4vE-3bc9A:
undetectable		 4j4vA-3bc9A:
17.01
4j4vE-3bc9A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 6 GLU A 141
TYR A 486
GLU A 144
GLU A 145
 None
 1.45A 4mi4A-3bc9A:
undetectable		 4mi4A-3bc9A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 7 TYR A 455
ASN A 232
TYR A 184
GLU A 380
 GLD  A 807 (-3.7A)
CA  A 702 (-3.1A)
ACI  A 806 ( 4.0A)
GLD  A 807 ( 2.8A)
 1.05A 4mi4A-3bc9A:
undetectable
4mi4C-3bc9A:
undetectable		 4mi4A-3bc9A:
15.99
4mi4C-3bc9A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 ASN A 221
ILE A 223
ALA A 214
VAL A 167
VAL A 225
 None
 1.03A 4nkvA-3bc9A:
undetectable		 4nkvA-3bc9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 ASN A 221
ILE A 223
ALA A 214
VAL A 167
VAL A 225
 None
 1.03A 4nkvD-3bc9A:
undetectable		 4nkvD-3bc9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 11 ILE A 223
LEU A 152
LEU A 169
ALA A 128
LEU A 126
 None
 1.11A 4p65E-3bc9A:
undetectable
4p65F-3bc9A:
undetectable
4p65J-3bc9A:
undetectable
4p65L-3bc9A:
undetectable		 4p65E-3bc9A:
2.58
4p65F-3bc9A:
4.47
4p65J-3bc9A:
4.47
4p65L-3bc9A:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 TYR A 504
GLY A 534
TYR A 562
GLU A 560
GLN A 110
 None
 1.47A 4qc6B-3bc9A:
undetectable		 4qc6B-3bc9A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 GLU A 323
ASP A 305
GLU A 301
GLY A 284
ALA A 318
 CA  A 701 (-3.3A)
CA  A 701 ( 3.0A)
None
None
None
 1.22A 4retC-3bc9A:
undetectable		 4retC-3bc9A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 ARG A 348
ASP A 350
GLU A 380
HIS A 446
ASP A 447
 ACI  A 806 (-3.3A)
ACI  A 806 (-3.1A)
GLD  A 807 ( 2.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.35A 5csyB-3bc9A:
5.8		 5csyB-3bc9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 4 ALA A 177
PRO A 171
LEU A 231
HIS A 233
 None
None
None
ACI  A 806 (-4.4A)
 1.11A 5eskA-3bc9A:
undetectable		 5eskA-3bc9A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 7 PHE A 527
ILE A 116
GLY A 532
TYR A 562
 None
 0.90A 5h3aA-3bc9A:
undetectable		 5h3aA-3bc9A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 7 GLU A 241
TYR A 239
ALA A 318
GLY A 284
 None
GLC  A1002 (-3.7A)
None
None
 0.67A 5uxdA-3bc9A:
undetectable		 5uxdA-3bc9A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 4 SER A 291
THR A 285
ASP A 283
ASP A 251
 None
None
CA  A 701 ( 2.2A)
None
 1.35A 5vimA-3bc9A:
undetectable		 5vimA-3bc9A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		4 / 6 PHE A 527
ILE A 116
GLY A 532
TYR A 562
 None
 0.91A 5x5qE-3bc9A:
undetectable		 5x5qE-3bc9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		6 / 7 LYS A 198
GLY A 236
TRP A 260
ASP A 286
TRP A 287
MET A 316
 G6D  A 801 (-3.5A)
GLC  A 802 ( 3.3A)
G6D  A 801 ( 3.6A)
ACI  A 803 (-2.6A)
GLC  A 802 ( 4.3A)
GLC  A 805 (-3.7A)
 0.38A 6ag0A-3bc9A:
48.4		 6ag0A-3bc9A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		10 / 12 TRP A 131
TYR A 184
HIS A 233
LEU A 315
MET A 316
ASP A 350
LYS A 353
HIS A 354
HIS A 446
ASP A 447
 None
ACI  A 806 ( 4.0A)
ACI  A 806 (-4.4A)
None
GLC  A 805 (-3.7A)
ACI  A 806 (-3.1A)
GLC  A 808 (-2.9A)
GLD  A 807 ( 3.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.43A 6ag0A-3bc9A:
48.4		 6ag0A-3bc9A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_0
(ALPHA-AMYLASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		8 / 12 TRP A 131
LEU A 315
MET A 316
ASP A 350
LYS A 353
HIS A 354
HIS A 446
ASP A 447
 None
None
GLC  A 805 (-3.7A)
ACI  A 806 (-3.1A)
GLC  A 808 (-2.9A)
GLD  A 807 ( 3.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
 0.45A 6ag0C-3bc9A:
48.4		 6ag0C-3bc9A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		6 / 7 LYS A 198
GLY A 236
TRP A 260
ASP A 286
TRP A 287
MET A 316
 G6D  A 801 (-3.5A)
GLC  A 802 ( 3.3A)
G6D  A 801 ( 3.6A)
ACI  A 803 (-2.6A)
GLC  A 802 ( 4.3A)
GLC  A 805 (-3.7A)
 0.38A 6ag0C-3bc9A:
48.4		 6ag0C-3bc9A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_A_NCTA501_1
(AMINE OXIDASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 10 LEU A 537
TYR A 520
GLU A 511
THR A 472
ASN A 431
 None
 1.42A 6c71A-3bc9A:
0.1		 6c71A-3bc9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 8 LEU A 537
TYR A 520
GLU A 511
THR A 472
ASN A 431
 None
 1.45A 6c71B-3bc9A:
undetectable		 6c71B-3bc9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_D_NCTD501_1
(AMINE OXIDASE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 9 LEU A 537
TYR A 520
GLU A 511
THR A 472
ASN A 431
 None
 1.47A 6c71D-3bc9A:
0.0		 6c71D-3bc9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		3 / 3 LEU A 429
GLY A 476
PHE A 376
 None
 0.60A 6exiC-3bc9A:
undetectable		 6exiC-3bc9A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3bc9 ALPHA AMYLASE,
CATALYTIC REGION
(Halothermothrix
orenii) 		5 / 12 ASN A  71
ILE A  44
ILE A  39
VAL A  92
PHE A  17
 None
 1.31A 6j21A-3bc9A:
undetectable		 6j21A-3bc9A:
21.79