SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		4 / 8 GLY A  78
GLU A 130
SER A 132
HIS A  81
 None
None
None
GOL  A 302 (-3.9A)
 0.96A 1ax9A-3bczA:
undetectable		 1ax9A-3bczA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		4 / 5 ILE A 133
SER A 123
ARG A 121
LEU A 157
 None
 1.14A 1y0xX-3bczA:
undetectable		 1y0xX-3bczA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		4 / 7 GLY A  78
GLU A 130
SER A 132
HIS A  81
 None
None
None
GOL  A 302 (-3.9A)
 0.93A 2ackA-3bczA:
undetectable		 2ackA-3bczA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		4 / 7 ARG A   8
ASP A 102
GLY A  21
PRO A 138
 None
 0.83A 2fxdB-3bczA:
undetectable		 2fxdB-3bczA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		5 / 12 ALA A  19
SER A  20
ALA A  10
PRO A 138
GLY A  14
 None
 1.10A 2igtA-3bczA:
undetectable		 2igtA-3bczA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		5 / 12 ALA A  19
SER A  20
ALA A  10
PRO A 138
GLY A  14
 None
 1.13A 2igtB-3bczA:
2.2		 2igtB-3bczA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		5 / 12 ALA A  19
SER A  20
ALA A  10
PRO A 138
GLY A  14
 None
 1.13A 2igtC-3bczA:
2.3		 2igtC-3bczA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		5 / 12 ARG A   8
ASP A 102
GLY A  21
PRO A 138
LEU A 137
 None
 1.00A 2o4nA-3bczA:
undetectable		 2o4nA-3bczA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		3 / 3 ILE A  74
ILE A  45
LEU A 113
 None
 0.42A 2prgA-3bczA:
undetectable		 2prgA-3bczA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		4 / 5 GLU A 166
PRO A 248
ILE A 249
GLY A 250
 GOL  A 303 (-3.7A)
None
None
GOL  A 303 ( 4.4A)
 1.01A 2qeuA-3bczA:
undetectable
2qeuC-3bczA:
undetectable		 2qeuA-3bczA:
20.41
2qeuC-3bczA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		5 / 10 ILE A 154
PHE A 173
TYR A  96
VAL A 158
LEU A  77
 None
 1.41A 2w98A-3bczA:
undetectable		 2w98A-3bczA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		3 / 3 HIS A  49
HIS A  81
HIS A 131
 GOL  A 302 (-4.0A)
GOL  A 302 (-3.9A)
GOL  A 302 (-4.0A)
 0.76A 3abkA-3bczA:
undetectable		 3abkA-3bczA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		3 / 3 HIS A  49
HIS A  81
HIS A 131
 GOL  A 302 (-4.0A)
GOL  A 302 (-3.9A)
GOL  A 302 (-4.0A)
 0.73A 3abkN-3bczA:
undetectable		 3abkN-3bczA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		4 / 7 ILE A  45
ILE A 243
LEU A 183
LEU A 253
 None
 0.88A 3adxA-3bczA:
undetectable		 3adxA-3bczA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		3 / 3 HIS A  49
HIS A  81
HIS A 131
 GOL  A 302 (-4.0A)
GOL  A 302 (-3.9A)
GOL  A 302 (-4.0A)
 0.75A 3ag1N-3bczA:
undetectable		 3ag1N-3bczA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		3 / 3 HIS A  49
HIS A  81
HIS A 131
 GOL  A 302 (-4.0A)
GOL  A 302 (-3.9A)
GOL  A 302 (-4.0A)
 0.73A 3ag4A-3bczA:
undetectable		 3ag4A-3bczA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		4 / 8 ARG A   8
ASP A 102
GLY A  21
PRO A 138
 None
 0.77A 3el9A-3bczA:
undetectable		 3el9A-3bczA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		5 / 9 ARG A   8
ASP A 102
GLY A  21
PRO A 138
LEU A 137
 None
 0.81A 3u7sB-3bczA:
undetectable		 3u7sB-3bczA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		5 / 12 ILE A  46
VAL A 186
LEU A  77
GLY A 170
LEU A 253
 None
 0.98A 4o1zA-3bczA:
undetectable		 4o1zA-3bczA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		3 / 3 GLU A 166
ILE A 224
ALA A 255
 GOL  A 303 (-3.7A)
None
None
 0.60A 4wnwB-3bczA:
undetectable		 4wnwB-3bczA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		5 / 12 LEU A 177
ALA A 255
LEU A 253
ALA A  44
ILE A 224
 None
 1.04A 4x20B-3bczA:
undetectable		 4x20B-3bczA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		5 / 12 LEU A 157
PHE A 270
PHE A 190
GLY A 220
LEU A 236
 None
 1.24A 5eshA-3bczA:
undetectable		 5eshA-3bczA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		4 / 4 ASP A 189
HIS A  49
HIS A  81
HIS A 192
 GOL  A 302 (-3.7A)
GOL  A 302 (-4.0A)
GOL  A 302 (-3.9A)
GOL  A 302 (-4.0A)
 1.19A 5ncdD-3bczA:
undetectable		 5ncdD-3bczA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		3 / 3 HIS A  49
HIS A  81
HIS A 131
 GOL  A 302 (-4.0A)
GOL  A 302 (-3.9A)
GOL  A 302 (-4.0A)
 0.75A 5waua-3bczA:
undetectable		 5waua-3bczA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		3 / 3 HIS A  49
HIS A  81
HIS A 131
 GOL  A 302 (-4.0A)
GOL  A 302 (-3.9A)
GOL  A 302 (-4.0A)
 0.60A 6giqa-3bczA:
undetectable		 6giqa-3bczA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3bcz PROTEIN MEMO1
(Homo
sapiens) 		3 / 3 HIS A  49
HIS A  81
HIS A 131
 GOL  A 302 (-4.0A)
GOL  A 302 (-3.9A)
GOL  A 302 (-4.0A)
 0.73A 6nmfN-3bczA:
undetectable		 6nmfN-3bczA:
19.02