SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bdk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		4 / 6 GLY A  29
ALA A  51
TYR A  28
GLU A  84
 None
None
None
DNO  A 387 ( 4.8A)
 1.01A 1dmaB-3bdkA:
undetectable		 1dmaB-3bdkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		3 / 3 SER A 190
GLU A 191
GLU A 192
 None
 0.63A 1eqbD-3bdkA:
undetectable		 1eqbD-3bdkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		3 / 3 SER A 190
GLU A 191
GLU A 192
 None
 0.64A 1eqbB-3bdkA:
undetectable		 1eqbB-3bdkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		3 / 3 ASP A 264
THR A 235
GLU A 191
 None
 0.74A 1pj7A-3bdkA:
undetectable		 1pj7A-3bdkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		3 / 3 ARG A 242
ASP A 221
ASP A 130
 None
None
DNO  A 387 (-3.4A)
 0.73A 2ejtA-3bdkA:
0.8		 2ejtA-3bdkA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		3 / 3 ARG A 350
THR A  35
VAL A  34
 None
 0.94A 2q64A-3bdkA:
undetectable		 2q64A-3bdkA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		3 / 3 ARG A 350
THR A  35
VAL A  34
 None
 0.92A 2qakA-3bdkA:
undetectable		 2qakA-3bdkA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		5 / 12 VAL A  49
GLU A  84
HIS A 219
ASP A 222
ASP A 330
 None
DNO  A 387 ( 4.8A)
MN  A 388 (-3.6A)
DNO  A 387 (-3.9A)
MN  A 388 (-2.7A)
 1.35A 2xinC-3bdkA:
22.0		 2xinC-3bdkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		4 / 7 TYR A 225
ILE A 227
ASP A 222
SER A 263
 None
None
DNO  A 387 (-3.9A)
None
 1.20A 2xytI-3bdkA:
undetectable		 2xytI-3bdkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		3 / 3 LYS A 266
ILE A 218
PHE A 125
 None
 0.98A 3j7zS-3bdkA:
undetectable
3j7za-3bdkA:
undetectable		 3j7zS-3bdkA:
13.92
3j7za-3bdkA:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		3 / 3 ASP A  32
GLY A 346
TYR A  28
 None
 0.77A 3w9tC-3bdkA:
undetectable		 3w9tC-3bdkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		3 / 3 ASP A  32
GLY A 346
TYR A  28
 None
 0.77A 3w9tG-3bdkA:
undetectable		 3w9tG-3bdkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		4 / 6 ARG A  99
ASP A 193
ASN A 197
TYR A 200
 None
 1.21A 3wfaA-3bdkA:
8.5
3wfaB-3bdkA:
5.7		 3wfaA-3bdkA:
20.30
3wfaB-3bdkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		5 / 12 ASP A 308
LEU A 150
GLY A 307
ASN A 289
GLY A 259
 None
 0.99A 4dc3A-3bdkA:
undetectable		 4dc3A-3bdkA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		5 / 12 ASP A 308
LEU A 150
GLY A 307
ASN A 289
GLY A 259
 None
 1.02A 4n09B-3bdkA:
undetectable		 4n09B-3bdkA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		4 / 8 TYR A 123
ILE A 202
ILE A 205
ALA A 209
 None
 0.88A 4ou1A-3bdkA:
6.6		 4ou1A-3bdkA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		3 / 3 LEU A 317
ASP A 320
TYR A 321
 None
 0.66A 4qc6B-3bdkA:
undetectable		 4qc6B-3bdkA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		4 / 5 LEU A 360
TYR A 356
ASN A 289
ILE A 309
 None
 1.13A 4y03B-3bdkA:
undetectable		 4y03B-3bdkA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3bdk D-MANNONATE
DEHYDRATASE
(Streptococcus
suis) 		5 / 12 MET A  45
ALA A  41
LEU A  78
ILE A  48
VAL A  34
 None
 1.40A 5vlmE-3bdkA:
undetectable		 5vlmE-3bdkA:
18.09