SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bdw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 7 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.80A 1dvxA-3bdwB:
undetectable		 1dvxA-3bdwB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 7 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.80A 1dvxB-3bdwB:
undetectable		 1dvxB-3bdwB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 6 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.95A 1ictB-3bdwB:
undetectable		 1ictB-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 5 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 1.03A 1tt6B-3bdwB:
undetectable		 1tt6B-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 7 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.84A 1tyrB-3bdwB:
undetectable		 1tyrB-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 7 LEU B 216
THR B 188
LEU B 211
SER B 173
 None
 0.99A 1tyrB-3bdwB:
undetectable		 1tyrB-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 6 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.99A 1tz8C-3bdwB:
undetectable
1tz8D-3bdwB:
undetectable		 1tz8C-3bdwB:
21.43
1tz8D-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 7 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.99A 3d2tA-3bdwB:
undetectable		 3d2tA-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 6 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.96A 4d7bB-3bdwB:
undetectable		 4d7bB-3bdwB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 6 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.96A 4i89A-3bdwB:
undetectable		 4i89A-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 6 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.97A 4pwjA-3bdwB:
undetectable		 4pwjA-3bdwB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 7 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.97A 4pwjB-3bdwB:
undetectable		 4pwjB-3bdwB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 211
PHE B 194
HIS B 196
GLU B 162
LEU B 166
 None
 1.13A 4r88A-3bdwB:
undetectable		 4r88A-3bdwB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 211
PHE B 194
HIS B 196
GLU B 162
LEU B 166
 None
 1.12A 4r88B-3bdwB:
undetectable		 4r88B-3bdwB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 211
PHE B 194
HIS B 196
GLU B 162
LEU B 166
 None
 1.13A 4r88C-3bdwB:
undetectable		 4r88C-3bdwB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 211
PHE B 194
HIS B 196
GLU B 162
LEU B 166
 None
 1.12A 4r88D-3bdwB:
undetectable		 4r88D-3bdwB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 211
PHE B 194
HIS B 196
GLU B 162
LEU B 166
 None
 1.10A 4r88E-3bdwB:
undetectable		 4r88E-3bdwB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU B 211
PHE B 194
HIS B 196
GLU B 162
LEU B 166
 None
 1.13A 4r88F-3bdwB:
undetectable		 4r88F-3bdwB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 6 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.94A 5bojA-3bdwB:
undetectable		 5bojA-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 7 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.93A 5bojB-3bdwB:
undetectable		 5bojB-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 6 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.93A 5l4iA-3bdwB:
undetectable		 5l4iA-3bdwB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3bdw NKG2-A/NKG2-B TYPE
II INTEGRAL MEMBRANE
PROTEIN
(Homo
sapiens) 		4 / 6 LEU B 216
ALA B 209
LEU B 211
SER B 173
 None
 0.92A 5l4iB-3bdwB:
undetectable		 5l4iB-3bdwB:
21.43