SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3be5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		4 / 6 ALA A 299
LEU A 297
SER A 294
SER A 291
 None
 1.05A 1tz8C-3be5A:
undetectable
1tz8D-3be5A:
undetectable		 1tz8C-3be5A:
18.18
1tz8D-3be5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		5 / 8 ILE A 306
ILE A 302
ARG A 204
ILE A 181
ALA A 287
 None
 1.33A 2nniA-3be5A:
undetectable		 2nniA-3be5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		3 / 3 LEU A  53
PRO A  52
LEU A  56
 None
 0.60A 2po5B-3be5A:
2.2		 2po5B-3be5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		3 / 3 GLY A  65
ASP A  46
SER A  63
 None
 0.62A 2qhfA-3be5A:
undetectable		 2qhfA-3be5A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		5 / 9 PHE A 211
VAL A 205
ILE A 306
ALA A 171
THR A 175
 None
 1.24A 3mdtA-3be5A:
undetectable		 3mdtA-3be5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		4 / 7 MET A 196
ILE A 288
ARG A  76
ARG A 284
 None
 1.48A 4f4dA-3be5A:
undetectable		 4f4dA-3be5A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		4 / 8 ASP A  85
ASP A  46
ASP A  70
GLU A 285
 None
 1.07A 4feuD-3be5A:
undetectable		 4feuD-3be5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		4 / 8 LEU A 111
VAL A  58
VAL A  61
LEU A 151
 None
 1.04A 4puoC-3be5A:
undetectable		 4puoC-3be5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_0
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		5 / 12 PRO A  52
GLU A  55
ILE A 288
GLN A 168
TYR A 145
 None
 1.22A 4rfqA-3be5A:
1.3		 4rfqA-3be5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		4 / 7 PHE A  86
ASP A  85
ILE A  75
GLY A  65
 None
 1.03A 4zxiA-3be5A:
2.7		 4zxiA-3be5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		4 / 7 SER A 294
ASP A  46
THR A 117
GLU A 115
 None
 0.98A 5btaA-3be5A:
undetectable
5btaC-3be5A:
undetectable
5btaD-3be5A:
undetectable		 5btaA-3be5A:
20.42
5btaC-3be5A:
20.42
5btaD-3be5A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		4 / 7 SER A 294
ASP A  46
THR A 117
GLU A 115
 None
 0.96A 5btfA-3be5A:
undetectable
5btfB-3be5A:
undetectable
5btfC-3be5A:
undetectable		 5btfA-3be5A:
20.42
5btfB-3be5A:
22.47
5btfC-3be5A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		3 / 3 ARG A 246
THR A 249
ASP A 248
 None
 0.89A 5g5gA-3be5A:
undetectable
5g5gB-3be5A:
undetectable		 5g5gA-3be5A:
21.84
5g5gB-3be5A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY
(Escherichia
coli) 		4 / 8 ASP A  46
HIS A 136
ARG A 118
GLU A 115
 None
 1.02A 6mn4D-3be5A:
undetectable		 6mn4D-3be5A:
22.70