SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ber'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		4 / 5 LEU A  59
VAL A  31
ALA A  38
CYH A  39
 None
 1.07A 1mz9D-3berA:
undetectable		 1mz9D-3berA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		4 / 4 GLN A  51
GLU A  53
ILE A  52
PRO A  47
 AMP  A 300 (-3.3A)
None
None
None
 1.21A 2fcnA-3berA:
undetectable		 2fcnA-3berA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		4 / 6 ARG A  62
ILE A  64
ILE A 145
LEU A  98
 None
 0.91A 2xkwB-3berA:
undetectable		 2xkwB-3berA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		5 / 9 VAL A 172
LEU A 220
ILE A  65
ILE A  55
GLY A  76
 None
 1.16A 3cv9A-3berA:
undetectable		 3cv9A-3berA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		4 / 8 LEU A 115
THR A  75
TRP A  44
GLY A  43
 None
AMP  A 300 (-3.6A)
AMP  A 300 (-3.5A)
None
 0.92A 3ny4A-3berA:
undetectable		 3ny4A-3berA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		3 / 3 THR A  99
VAL A  97
GLU A 175
 None
 0.69A 3v4tA-3berA:
1.2
3v4tD-3berA:
1.3		 3v4tA-3berA:
19.44
3v4tD-3berA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		5 / 10 ILE A 108
LEU A 104
GLY A  76
GLY A  73
SER A  72
 None
None
None
AMP  A 300 (-3.3A)
AMP  A 300 (-4.1A)
 1.20A 4bwlC-3berA:
undetectable		 4bwlC-3berA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		5 / 12 LEU A 192
LEU A 220
LEU A 215
ALA A 176
ILE A 179
 PGE  A 401 (-3.9A)
None
None
None
None
 1.09A 4x1iD-3berA:
2.5		 4x1iD-3berA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		5 / 11 LEU A 192
LEU A 220
LEU A 215
ALA A 176
ILE A 179
 PGE  A 401 (-3.9A)
None
None
None
None
 1.14A 4x20D-3berA:
undetectable		 4x20D-3berA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		4 / 7 ILE A 130
GLY A 128
LEU A 165
ASP A 155
 None
PO4  A 350 (-3.9A)
None
PO4  A 350 ( 3.1A)
 0.75A 5hieB-3berA:
undetectable		 5hieB-3berA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		4 / 4 GLU A 175
THR A  99
THR A 201
LEU A 215
 None
 1.46A 5v96B-3berA:
2.3		 5v96B-3berA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		4 / 7 PHE A  26
VAL A  31
PRO A  81
ILE A  82
 AMP  A 300 (-4.9A)
None
None
None
 1.19A 5vkqA-3berA:
undetectable
5vkqB-3berA:
undetectable		 5vkqA-3berA:
9.61
5vkqB-3berA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		4 / 7 PHE A  26
VAL A  31
PRO A  81
ILE A  82
 AMP  A 300 (-4.9A)
None
None
None
 1.19A 5vkqC-3berA:
undetectable
5vkqD-3berA:
undetectable		 5vkqC-3berA:
9.61
5vkqD-3berA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47
(Homo
sapiens) 		5 / 12 PHE A  26
GLY A  76
ALA A  77
ILE A  52
LEU A  29
 AMP  A 300 (-4.9A)
None
None
None
None
 0.90A 6dwnD-3berA:
undetectable		 6dwnD-3berA:
18.60