SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3beu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 8 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.52A 1aq7A-3beuA:
32.1		 1aq7A-3beuA:
36.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.25A 1bcuH-3beuA:
32.2		 1bcuH-3beuA:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.5A)
 0.30A 1dwcH-3beuA:
31.4		 1dwcH-3beuA:
34.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.49A 1etrH-3beuA:
31.3		 1etrH-3beuA:
35.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 8 ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 4.1A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.57A 1f5lA-3beuA:
31.1		 1f5lA-3beuA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 12 GLY A  69
GLY A  44
THR A  67
ALA A  66
VAL A  83
 None
 1.06A 1jg2A-3beuA:
undetectable		 1jg2A-3beuA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 12 GLY A  69
GLY A  44
THR A  67
ALA A  66
VAL A  83
 None
 1.06A 1jg4A-3beuA:
undetectable		 1jg4A-3beuA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		3 / 3 LEU A 105
LEU A  89
SER A  60
 None
BEN  A   8 ( 4.6A)
None
 0.66A 1tlmA-3beuA:
undetectable		 1tlmA-3beuA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.29A 1tnlA-3beuA:
32.1		 1tnlA-3beuA:
36.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.16A 2otvA-3beuA:
32.3		 2otvA-3beuA:
36.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
None
None
SO4  A 246 (-3.6A)
None
None
 1.44A 2oxtD-3beuA:
undetectable		 2oxtD-3beuA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3beu TRYPSIN
(Streptomyces
griseus) 		8 / 12 PHE A 174
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
None
 0.48A 2p16A-3beuA:
33.2		 2p16A-3beuA:
41.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 8 ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 4.1A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.76A 2vinA-3beuA:
32.1		 2vinA-3beuA:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		9 / 12 PHE A 174
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
None
BEN  A 247 (-3.5A)
None
 0.37A 2w26A-3beuA:
33.0		 2w26A-3beuA:
41.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 7 VAL A  52
ILE A 106
ALA A  66
GLY A  44
THR A  54
 None
 1.18A 2xrzB-3beuA:
undetectable		 2xrzB-3beuA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3beu TRYPSIN
(Streptomyces
griseus) 		4 / 7 THR A  54
ILE A 106
ILE A  64
SER A  34
 None
 0.80A 3deuA-3beuA:
undetectable		 3deuA-3beuA:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		6 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.33A 3gy3A-3beuA:
32.2		 3gy3A-3beuA:
36.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 10 ILE A 212
ASP A 102
THR A 229
ILE A 123
ILE A 238
 None
 1.43A 3kpbD-3beuA:
undetectable		 3kpbD-3beuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 12 PHE A 136
ALA A  91
ILE A 238
ALA A 235
GLY A 211
 None
 0.98A 3nxuA-3beuA:
undetectable		 3nxuA-3beuA:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.25A 3rxfA-3beuA:
17.4		 3rxfA-3beuA:
36.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		4 / 5 ASP A 189
SER A 195
VAL A 213
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.5A)
 0.34A 3rxhA-3beuA:
32.2		 3rxhA-3beuA:
36.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 10 LEU A  53
ILE A 106
ILE A 212
GLY A 196
GLY A  43
 None
 1.00A 4fakA-3beuA:
undetectable		 4fakA-3beuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 10 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
 None
 0.88A 4fakA-3beuA:
undetectable		 4fakA-3beuA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 12 HIS A  57
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
None
None
BEN  A 247 (-3.5A)
 0.22A 4hfpD-3beuA:
31.3		 4hfpD-3beuA:
33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 12 ALA A  55
ILE A 212
GLY A  44
VAL A  88
ILE A 106
 None
 0.93A 4q5mA-3beuA:
undetectable		 4q5mA-3beuA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 3beu TRYPSIN
(Streptomyces
griseus) 		3 / 3 ASP A 102
HIS A  57
LYS A  96
 None
SO4  A 246 ( 3.8A)
None
 0.85A 4qzuD-3beuA:
undetectable		 4qzuD-3beuA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 12 HIS A  57
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 SO4  A 246 ( 3.8A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.29A 4rn6B-3beuA:
26.5		 4rn6B-3beuA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3beu TRYPSIN
(Streptomyces
griseus) 		3 / 3 SER A 214
SER A 195
PHE A  94
 None
SO4  A 246 ( 2.5A)
None
 0.85A 5mugA-3beuA:
undetectable		 5mugA-3beuA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 9 ALA A 237
ILE A 238
PRO A  92
ALA A 104
LEU A 105
 None
 0.88A 5mvmA-3beuA:
undetectable
5mvmE-3beuA:
undetectable		 5mvmA-3beuA:
19.44
5mvmE-3beuA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 10 PRO A  92
ALA A 104
LEU A 105
ALA A 237
ILE A 238
 None
 0.88A 5mvmD-3beuA:
undetectable
5mvmE-3beuA:
undetectable		 5mvmD-3beuA:
19.44
5mvmE-3beuA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3beu TRYPSIN
(Streptomyces
griseus) 		5 / 12 GLY A 142
GLY A 196
GLY A  43
GLY A 140
PHE A  94
 None
 0.96A 5vimB-3beuA:
undetectable		 5vimB-3beuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3beu TRYPSIN
(Streptomyces
griseus) 		4 / 8 GLY A 216
GLY A 193
SER A 195
ALA A  55
 BEN  A 247 (-3.7A)
SO4  A 246 (-3.6A)
SO4  A 246 ( 2.5A)
None
 0.79A 6hu9H-3beuA:
undetectable
6hu9e-3beuA:
undetectable		 6hu9H-3beuA:
17.06
6hu9e-3beuA:
20.64