SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bf0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 11 ALA A 495
ILE A 421
LEU A 526
LEU A 522
GLY A 521
 None
 0.96A 1b02A-3bf0A:
undetectable		 1b02A-3bf0A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 3bf0 PROTEASE 4
(Escherichia
coli) 		4 / 7 THR A 352
THR A 343
GLY A 340
ASP A 339
 None
 0.98A 1bu5A-3bf0A:
2.4		 1bu5A-3bf0A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 11 ALA A 333
VAL A 384
ALA A 387
ALA A 390
LEU A 370
 None
 1.03A 1jinA-3bf0A:
undetectable		 1jinA-3bf0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 3 ASP A 362
ASP A 358
LYS A 397
 None
 1.11A 1lqtB-3bf0A:
undetectable		 1lqtB-3bf0A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 3 ASP A 362
ASP A 358
LYS A 397
 None
 1.13A 1lquB-3bf0A:
undetectable		 1lquB-3bf0A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		4 / 7 GLY A 411
PRO A 417
ALA A 418
ILE A 421
 None
 0.73A 1n49A-3bf0A:
undetectable		 1n49A-3bf0A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 3 GLU A 292
ASN A 307
TRP A 301
 None
 1.03A 1r15C-3bf0A:
undetectable		 1r15C-3bf0A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 3 GLU A 292
ASN A 307
TRP A 301
 None
 1.06A 1r15D-3bf0A:
undetectable		 1r15D-3bf0A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 3 GLU A 292
ASN A 307
TRP A 301
 None
 1.05A 1r15E-3bf0A:
2.3		 1r15E-3bf0A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 3 GLU A 292
ASN A 307
TRP A 301
 None
 1.07A 1r15F-3bf0A:
2.2		 1r15F-3bf0A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3bf0 PROTEASE 4
(Escherichia
coli) 		4 / 5 GLY A 411
PRO A 417
ALA A 418
ILE A 421
 None
 0.67A 2aofA-3bf0A:
undetectable		 2aofA-3bf0A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 12 LEU A 370
ALA A 333
VAL A 347
ARG A 487
LEU A 491
 None
 1.12A 2g78A-3bf0A:
undetectable		 2g78A-3bf0A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 9 ILE A 414
ILE A 337
THR A 352
VAL A 347
LEU A 370
 None
 1.18A 2m9qA-3bf0A:
undetectable		 2m9qA-3bf0A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 3 GLY A 527
ASP A 531
SER A 525
 None
 0.73A 2qhfA-3bf0A:
undetectable		 2qhfA-3bf0A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 12 ASP A 524
ILE A 506
ILE A 503
ARG A 496
ALA A 407
 None
 1.15A 2qmjA-3bf0A:
2.9		 2qmjA-3bf0A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 12 LEU A 522
SER A 498
ALA A 493
SER A 431
GLY A 509
 None
 1.05A 2vmyA-3bf0A:
undetectable		 2vmyA-3bf0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		4 / 5 ARG A 105
ASP A 530
GLU A 140
LYS A 136
 None
 0.98A 2xrzA-3bf0A:
undetectable
2xrzB-3bf0A:
undetectable		 2xrzA-3bf0A:
23.92
2xrzB-3bf0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 12 TYR A 420
ARG A 496
ILE A 328
VAL A 330
PHE A 529
 None
 1.29A 2zznA-3bf0A:
undetectable		 2zznA-3bf0A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 3 TYR A 133
ASP A  69
HIS A 546
 None
 0.85A 3e23A-3bf0A:
undetectable		 3e23A-3bf0A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 12 ALA A 495
ILE A 421
LEU A 526
LEU A 522
GLY A 521
 None
 1.03A 3k2hA-3bf0A:
undetectable		 3k2hA-3bf0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 12 ALA A 495
ILE A 421
LEU A 526
LEU A 522
GLY A 521
 None
 1.05A 3k2hB-3bf0A:
undetectable		 3k2hB-3bf0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 3 ASP A 127
SER A 130
ARG A 371
 None
 0.81A 3loqA-3bf0A:
3.3		 3loqA-3bf0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		4 / 6 ALA A 333
ILE A 385
LEU A 370
ALA A 407
 None
 0.84A 3r9sA-3bf0A:
12.5		 3r9sA-3bf0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		4 / 6 ALA A 333
ILE A 385
LEU A 370
ALA A 407
 None
 0.89A 3r9sC-3bf0A:
11.9		 3r9sC-3bf0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 12 LEU A 138
ILE A  63
ILE A 100
ILE A 113
ASP A 119
 None
 1.00A 3uj6A-3bf0A:
undetectable		 3uj6A-3bf0A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 12 LEU A 138
ILE A  63
ILE A 100
ILE A 113
ASP A 119
 None
 0.97A 3uj7A-3bf0A:
undetectable		 3uj7A-3bf0A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 12 TYR A 314
ILE A  67
ILE A 134
LEU A 138
VAL A 148
 None
 0.96A 3w68D-3bf0A:
2.9		 3w68D-3bf0A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		4 / 5 TYR A 149
THR A 296
PHE A 299
ILE A 291
 None
 1.26A 4jx1E-3bf0A:
undetectable		 4jx1E-3bf0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 11 TYR A 485
VAL A 492
ALA A 493
GLY A 433
PHE A 488
 None
 1.18A 4mm9A-3bf0A:
undetectable		 4mm9A-3bf0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 5 GLY A 335
GLY A 345
GLU A 342
 None
 0.46A 4z2eA-3bf0A:
undetectable
4z2eD-3bf0A:
undetectable		 4z2eA-3bf0A:
21.96
4z2eD-3bf0A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3bf0 PROTEASE 4
(Escherichia
coli) 		4 / 5 LYS A 274
ALA A 276
LEU A 281
LEU A 285
 None
 0.84A 5vkqA-3bf0A:
undetectable
5vkqD-3bf0A:
undetectable		 5vkqA-3bf0A:
16.39
5vkqD-3bf0A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3bf0 PROTEASE 4
(Escherichia
coli) 		4 / 5 LEU A 285
LYS A 274
ALA A 276
LEU A 281
 None
 0.86A 5vkqA-3bf0A:
undetectable
5vkqB-3bf0A:
undetectable		 5vkqA-3bf0A:
16.39
5vkqB-3bf0A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3bf0 PROTEASE 4
(Escherichia
coli) 		4 / 5 LEU A 285
LYS A 274
ALA A 276
LEU A 281
 None
 0.87A 5vkqC-3bf0A:
undetectable
5vkqD-3bf0A:
undetectable		 5vkqC-3bf0A:
16.39
5vkqD-3bf0A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3bf0 PROTEASE 4
(Escherichia
coli) 		3 / 3 GLY A 430
VAL A 372
MET A 403
 None
 0.64A 5ycpA-3bf0A:
undetectable		 5ycpA-3bf0A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3bf0 PROTEASE 4
(Escherichia
coli) 		5 / 9 LEU A 389
ILE A 368
ARG A 360
VAL A 331
ILE A 356
 None
 1.16A 6ef6A-3bf0A:
undetectable		 6ef6A-3bf0A:
24.01