SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION
(Ruegeria
sp.
TM1040) 		4 / 4 LEU A 159
PRO A 156
LEU A  48
ARG A  49
 None
None
None
CA  A 235 ( 4.1A)
 1.35A 1hrkB-3bfmA:
undetectable		 1hrkB-3bfmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION
(Ruegeria
sp.
TM1040) 		3 / 3 THR A  45
GLU A  42
ASP A  24
 None
CA  A 235 (-2.1A)
None
 0.84A 1nt2A-3bfmA:
undetectable		 1nt2A-3bfmA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION
(Ruegeria
sp.
TM1040) 		3 / 3 ARG A 196
VAL A 208
TRP A  92
 None
 0.98A 1qwcA-3bfmA:
undetectable		 1qwcA-3bfmA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 159
LEU A  48
GLY A 125
ALA A  51
ALA A  26
 None
 1.14A 2br4E-3bfmA:
undetectable		 2br4E-3bfmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION
(Ruegeria
sp.
TM1040) 		4 / 4 LEU A 159
PRO A 156
LEU A  48
ARG A  49
 None
None
None
CA  A 235 ( 4.1A)
 1.33A 2hrcA-3bfmA:
undetectable		 2hrcA-3bfmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION
(Ruegeria
sp.
TM1040) 		4 / 4 LEU A 159
PRO A 156
LEU A  48
ARG A  49
 None
None
None
CA  A 235 ( 4.1A)
 1.37A 2hrcB-3bfmA:
undetectable		 2hrcB-3bfmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION
(Ruegeria
sp.
TM1040) 		4 / 4 LEU A 159
PRO A 156
LEU A  48
ARG A  49
 None
None
None
CA  A 235 ( 4.1A)
 1.31A 2pnjB-3bfmA:
undetectable		 2pnjB-3bfmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 126
LEU A 106
ALA A  95
ASP A 141
THR A 139
 None
 1.26A 3gwuA-3bfmA:
undetectable		 3gwuA-3bfmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION
(Ruegeria
sp.
TM1040) 		3 / 3 ARG A 196
VAL A 208
TRP A  92
 None
 1.03A 5fvoA-3bfmA:
undetectable		 5fvoA-3bfmA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION
(Ruegeria
sp.
TM1040) 		3 / 3 ASP A 135
ASP A 141
ASN A  93
 None
 0.67A 6gngB-3bfmA:
undetectable		 6gngB-3bfmA:
17.35