SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		4 / 6 HIS A 114
ILE A 111
ALA A 150
VAL A 123
 None
 0.94A 1hk1A-3bfnA:
undetectable		 1hk1A-3bfnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		5 / 12 THR A 136
GLY A 127
ALA A 125
ILE A 342
ALA A 346
 None
 1.13A 1vq1A-3bfnA:
undetectable		 1vq1A-3bfnA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		3 / 3 ARG A 266
VAL A 172
THR A 158
 None
 0.81A 2nmzA-3bfnA:
undetectable		 2nmzA-3bfnA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		4 / 4 ILE A 340
THR A 136
LYS A 133
TYR A  94
 None
None
ADP  A 802 (-2.8A)
None
 1.48A 3elzA-3bfnA:
0.0		 3elzA-3bfnA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		4 / 5 LYS A 213
PRO A 214
SER A 216
LEU A 188
 None
 1.38A 3ijxH-3bfnA:
undetectable		 3ijxH-3bfnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		4 / 5 LYS A 213
PRO A 214
SER A 216
LEU A 188
 None
 1.48A 3iluH-3bfnA:
undetectable		 3iluH-3bfnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		4 / 8 PRO A 214
SER A 175
LEU A 188
ASP A 186
 None
 0.98A 3lsfH-3bfnA:
undetectable		 3lsfH-3bfnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		3 / 3 ARG A 266
VAL A 172
THR A 158
 None
 0.87A 3pwrA-3bfnA:
undetectable		 3pwrA-3bfnA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		3 / 3 GLY A 130
GLY A 132
THR A 134
 ADP  A 802 (-3.7A)
ADP  A 802 (-3.3A)
MG  A 801 ( 3.1A)
 0.43A 3si7B-3bfnA:
undetectable		 3si7B-3bfnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		5 / 12 ILE A 215
ALA A 219
LEU A 226
ILE A 147
LEU A 250
 None
 1.10A 4ej1B-3bfnA:
undetectable		 4ej1B-3bfnA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		5 / 12 GLN A 330
LEU A 333
VAL A 303
LEU A 304
ILE A 179
 None
 1.12A 4g1bA-3bfnA:
undetectable		 4g1bA-3bfnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		4 / 8 VAL A 146
TYR A 104
LEU A 115
LEU A 270
 None
 1.05A 4jtrA-3bfnA:
undetectable		 4jtrA-3bfnA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		4 / 5 ILE A 205
ARG A 202
GLU A 199
VAL A 196
 None
 0.86A 4nkxC-3bfnA:
undetectable		 4nkxC-3bfnA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		5 / 12 ILE A 215
ALA A 219
LEU A 226
ILE A 147
LEU A 250
 None
 1.07A 4qi9A-3bfnA:
undetectable		 4qi9A-3bfnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		5 / 12 ILE A 215
ALA A 219
LEU A 226
ILE A 147
LEU A 250
 None
 1.11A 4qi9B-3bfnA:
undetectable		 4qi9B-3bfnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		5 / 12 ARG A 245
GLY A 277
GLU A 279
GLY A 127
GLU A 348
 None
 1.01A 5ul4A-3bfnA:
undetectable		 5ul4A-3bfnA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		5 / 10 LEU A 272
ILE A 215
LEU A 155
LEU A 157
LEU A 115
 None
None
UNX  A 708 ( 4.9A)
None
None
 1.22A 5y7pG-3bfnA:
undetectable		 5y7pG-3bfnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		4 / 5 VAL A 108
LEU A 270
VAL A 172
LEU A 116
 None
 0.86A 6bqgA-3bfnA:
undetectable		 6bqgA-3bfnA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens) 		4 / 4 ASP A 194
ILE A 207
PRO A 208
LEU A 195
 None
 1.46A 6mkeB-3bfnA:
undetectable		 6mkeB-3bfnA:
12.60