SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bg0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 434
ALA B 426
LEU B 424
THR B 456
 None
 0.94A 1dvtA-3bg0B:
undetectable
1dvtB-3bg0B:
undetectable		 1dvtA-3bg0B:
15.07
1dvtB-3bg0B:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 6 ILE B 357
GLU B 374
LEU B 375
LEU B 296
 None
 0.94A 1mt1B-3bg0B:
undetectable
1mt1C-3bg0B:
undetectable		 1mt1B-3bg0B:
13.54
1mt1C-3bg0B:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 11 ARG B 513
GLY B 488
GLU B 514
SER B 490
ILE B 526
 None
 1.43A 1odiA-3bg0B:
undetectable		 1odiA-3bg0B:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 10 ARG B 513
GLY B 488
GLU B 514
SER B 490
ILE B 526
 None
 1.42A 1pw7A-3bg0B:
undetectable		 1pw7A-3bg0B:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		3 / 3 LEU B 399
LEU B 402
SER B 405
 None
 0.67A 1tlmA-3bg0B:
undetectable		 1tlmA-3bg0B:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 434
ALA B 426
LEU B 424
SER B 237
 None
 0.61A 1tz8C-3bg0B:
undetectable
1tz8D-3bg0B:
undetectable		 1tz8C-3bg0B:
15.30
1tz8D-3bg0B:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 536
ILE B 532
LEU B 518
ARG B 519
ILE B 515
 None
 0.73A 2f78A-3bg0B:
undetectable		 2f78A-3bg0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 536
ILE B 532
LEU B 518
ARG B 519
ILE B 515
 None
 0.81A 2f78B-3bg0B:
undetectable		 2f78B-3bg0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 536
ILE B 532
LEU B 518
ARG B 519
ILE B 515
 None
 0.82A 2f7aA-3bg0B:
undetectable		 2f7aA-3bg0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 536
ILE B 532
LEU B 518
ARG B 519
ILE B 515
 None
 0.77A 2f7aB-3bg0B:
undetectable		 2f7aB-3bg0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 10 LEU B 536
ILE B 532
LEU B 518
ARG B 519
ILE B 515
 None
 0.76A 2f8dA-3bg0B:
undetectable		 2f8dA-3bg0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 10 LEU B 536
ILE B 532
LEU B 518
ARG B 519
ILE B 515
 None
 0.76A 2f8dB-3bg0B:
undetectable		 2f8dB-3bg0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 231
GLN B 275
ILE B 239
SER B 274
 None
 0.90A 2xz5B-3bg0B:
undetectable
2xz5E-3bg0B:
undetectable		 2xz5B-3bg0B:
20.32
2xz5E-3bg0B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 7 GLN B 275
ILE B 239
SER B 274
TYR B 231
 None
 0.92A 2xz5D-3bg0B:
undetectable
2xz5E-3bg0B:
undetectable		 2xz5D-3bg0B:
20.32
2xz5E-3bg0B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 399
VAL B 403
ILE B 239
LEU B 240
THR B 388
 None
 1.25A 3fl9C-3bg0B:
undetectable		 3fl9C-3bg0B:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		3 / 3 SER B 534
GLN B 535
PHE B 538
 None
 0.50A 3g4lC-3bg0B:
undetectable		 3g4lC-3bg0B:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		3 / 3 ARG B 181
LEU B 184
THR B 177
 None
 0.81A 3oxcA-3bg0B:
undetectable		 3oxcA-3bg0B:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 165
GLY B 169
LYS B 162
 None
 0.77A 4k50A-3bg0B:
undetectable		 4k50A-3bg0B:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 165
GLY B 169
LYS B 162
 None
 0.77A 4k50I-3bg0B:
undetectable		 4k50I-3bg0B:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		3 / 3 THR B 431
ASN B 460
PHE B 459
 None
 0.77A 4pd9A-3bg0B:
undetectable		 4pd9A-3bg0B:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 179
VAL B 493
SER B 490
HIS B 489
 None
 0.86A 4qknA-3bg0B:
undetectable		 4qknA-3bg0B:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 6 ASN B 353
GLU B 378
LEU B 296
PHE B 379
 None
 1.32A 4twdB-3bg0B:
undetectable
4twdC-3bg0B:
undetectable		 4twdB-3bg0B:
21.44
4twdC-3bg0B:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		3 / 3 SER B 213
ASP B 186
ASP B 219
 None
 0.45A 4uckA-3bg0B:
undetectable		 4uckA-3bg0B:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 6 ALA B 540
GLN B 541
LEU B 536
LEU B 527
 None
 0.90A 4xoyA-3bg0B:
undetectable		 4xoyA-3bg0B:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 236
ILE B 418
GLY B 419
VAL B 403
LEU B 385
 None
 1.01A 4y8wA-3bg0B:
undetectable		 4y8wA-3bg0B:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3bg0 NUCLEOPORIN NUP145
(Saccharomyces
cerevisiae) 		4 / 8 SER B 327
ARG B 331
PRO B 330
ILE B 332
 None
 0.84A 5jhdE-3bg0B:
undetectable
5jhdG-3bg0B:
undetectable		 5jhdE-3bg0B:
19.78
5jhdG-3bg0B:
11.19