SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		5 / 11 ALA A 201
GLU A 376
ARG A 375
ARG A 329
LEU A 317
 None
 1.35A 1mjlA-3bgwA:
undetectable
1mjlB-3bgwA:
undetectable		 1mjlA-3bgwA:
13.85
1mjlB-3bgwA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		5 / 11 LEU A 320
ALA A 353
SER A 355
LEU A 380
SER A 377
 None
 1.31A 1tz8A-3bgwA:
undetectable
1tz8B-3bgwA:
undetectable		 1tz8A-3bgwA:
16.90
1tz8B-3bgwA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		5 / 11 LEU A 380
SER A 377
LEU A 320
ALA A 353
SER A 355
 None
 1.30A 1tz8A-3bgwA:
undetectable
1tz8B-3bgwA:
undetectable		 1tz8A-3bgwA:
16.90
1tz8B-3bgwA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		5 / 9 SER A 279
LEU A 213
ILE A 276
ALA A 246
GLY A 181
 None
 0.86A 2v0mB-3bgwA:
undetectable		 2v0mB-3bgwA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		4 / 4 LEU A  75
PRO A  76
LEU A  78
ARG A  70
 None
 1.34A 3hcoB-3bgwA:
2.6		 3hcoB-3bgwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		5 / 12 SER A 279
LEU A 213
ILE A 276
ALA A 246
GLY A 181
 None
 0.94A 3nxuA-3bgwA:
undetectable		 3nxuA-3bgwA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		5 / 12 ALA A 344
LYS A 341
LEU A 340
ALA A 353
ILE A 314
 None
 1.19A 3ut5D-3bgwA:
2.8		 3ut5D-3bgwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		5 / 12 ILE A 175
GLY A 191
ILE A 311
VAL A 226
ASP A 224
 None
 1.04A 4a81A-3bgwA:
undetectable		 4a81A-3bgwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		4 / 7 ILE A 200
LEU A 390
PHE A 432
GLY A 430
 None
 0.85A 4hajA-3bgwA:
undetectable		 4hajA-3bgwA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		5 / 12 LEU A 354
LEU A 199
ILE A 333
ILE A 336
LEU A 319
 None
 1.19A 4j24C-3bgwA:
undetectable		 4j24C-3bgwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		6 / 12 LEU A 357
LEU A 317
LEU A 374
ALA A 384
ALA A 353
ILE A 387
 None
 1.44A 4o2bD-3bgwA:
undetectable		 4o2bD-3bgwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		3 / 3 ASP A 186
LEU A 185
PHE A 182
 None
 0.53A 4pthA-3bgwA:
undetectable		 4pthA-3bgwA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		4 / 6 ASP A 373
ILE A 409
ARG A 368
TYR A 391
 None
 1.03A 5igyA-3bgwA:
undetectable		 5igyA-3bgwA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		4 / 6 ASP A 373
ILE A 409
ARG A 368
TYR A 391
 None
 1.05A 5iwuA-3bgwA:
undetectable		 5iwuA-3bgwA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		4 / 5 SER A  90
VAL A  91
GLY A  21
ALA A  18
 None
 1.06A 5k50A-3bgwA:
undetectable		 5k50A-3bgwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		3 / 3 GLU A  16
HIS A  39
VAL A 104
 None
 0.75A 5trqB-3bgwA:
undetectable		 5trqB-3bgwA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3bgw DNAB-LIKE
REPLICATIVE HELICASE
(Bacillus
phage
SPP1) 		3 / 3 THR A  51
GLU A  16
ASN A  47
 None
 0.87A 6nj9K-3bgwA:
undetectable		 6nj9K-3bgwA:
21.13