SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3bhg ADENYLOSUCCINATE
LYASE
(Legionella
pneumophila) 		4 / 8 GLY A 315
ASN A 318
ILE A 147
VAL A 257
 None
 0.74A 2yoeB-3bhgA:
3.6
2yoeC-3bhgA:
3.6		 2yoeB-3bhgA:
21.23
2yoeC-3bhgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3bhg ADENYLOSUCCINATE
LYASE
(Legionella
pneumophila) 		4 / 8 LEU A 337
ARG A 335
GLU A 124
HIS A  91
 None
None
None
SO4  A 501 ( 3.7A)
 1.33A 3zmdA-3bhgA:
undetectable
3zmdB-3bhgA:
0.5		 3zmdA-3bhgA:
17.07
3zmdB-3bhgA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3bhg ADENYLOSUCCINATE
LYASE
(Legionella
pneumophila) 		4 / 8 SER A 331
ASP A 336
VAL A 342
THR A 341
 None
 1.12A 4lnwA-3bhgA:
undetectable		 4lnwA-3bhgA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 3bhg ADENYLOSUCCINATE
LYASE
(Legionella
pneumophila) 		4 / 8 GLY A  14
THR A  20
TYR A  16
ARG A  15
 None
 1.19A 4m5mA-3bhgA:
undetectable		 4m5mA-3bhgA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3bhg ADENYLOSUCCINATE
LYASE
(Legionella
pneumophila) 		5 / 12 LEU A  32
THR A 122
VAL A  96
ALA A  95
ILE A 126
 None
 1.08A 4x1kD-3bhgA:
undetectable		 4x1kD-3bhgA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3bhg ADENYLOSUCCINATE
LYASE
(Legionella
pneumophila) 		5 / 12 LEU A 167
VAL A 384
PRO A 177
THR A 178
GLU A 183
 None
 1.33A 5xipD-3bhgA:
undetectable		 5xipD-3bhgA:
23.18