SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bi3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		5 / 12 ARG A 183
GLY A 108
ALA A 107
VAL A 175
VAL A 177
 None
 0.94A 1k6cB-3bi3A:
undetectable		 1k6cB-3bi3A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 7 PHE A 154
LEU A 168
SER A 147
THR A 208
 None
None
AKG  A 302 ( 4.7A)
AKG  A 302 (-3.7A)
 1.05A 4wnvD-3bi3A:
undetectable		 4wnvD-3bi3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 4 SER A  42
ALA A  41
GLN A  84
THR A  62
 None
 1.28A 5n0rA-3bi3A:
undetectable		 5n0rA-3bi3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 4 SER A  42
ALA A  41
GLN A  84
THR A  62
 None
 1.28A 5n0sA-3bi3A:
undetectable		 5n0sA-3bi3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 5 SER A  42
ALA A  41
GLN A  84
THR A  62
 None
 1.31A 5n0tA-3bi3A:
undetectable		 5n0tA-3bi3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 4 SER A  42
ALA A  41
GLN A  84
THR A  62
 None
 1.25A 5n0wA-3bi3A:
undetectable		 5n0wA-3bi3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 5 SER A  42
ALA A  41
GLN A  84
THR A  62
 None
 1.24A 5n0wB-3bi3A:
undetectable		 5n0wB-3bi3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 4 SER A  42
ALA A  41
GLN A  84
THR A  62
 None
 1.27A 5n0xA-3bi3A:
undetectable		 5n0xA-3bi3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 5 SER A  42
ALA A  41
GLN A  84
THR A  62
 None
 1.22A 5n4iA-3bi3A:
undetectable		 5n4iA-3bi3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 5 ALA A  19
SER A 182
GLY A 180
TYR A 109
 None
 1.11A 5yodB-3bi3A:
undetectable		 5yodB-3bi3A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 5 ALA A  19
SER A 182
GLY A 180
TYR A 109
 None
 1.05A 5yodD-3bi3A:
undetectable		 5yodD-3bi3A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 7 SER A 145
SER A 147
GLY A 173
ARG A 204
 AKG  A 302 ( 3.8A)
AKG  A 302 ( 4.7A)
None
AKG  A 302 (-2.8A)
 0.97A 6btxA-3bi3A:
undetectable		 6btxA-3bi3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
(Escherichia
coli) 		4 / 5 HIS A 131
ASP A 133
HIS A 187
ARG A 210
 MN  A 301 ( 3.3A)
MN  A 301 ( 2.5A)
MN  A 301 ( 3.3A)
AKG  A 302 (-3.9A)
 1.20A 6dchA-3bi3A:
5.3		 6dchA-3bi3A:
21.17