SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D33_A_MTLA870_0 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	3bib	T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN-CONTAINING PROTEIN 4 (Mus musculus)	4 / 8	ASN X 28 ILE X 92 ASN X 99 ASP X 100	None None NA X 117 ( 3.2A) PSF X 118 ( 2.9A)	1.14A	4d33A-3bibX: undetectable	4d33A-3bibX: 11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UBB_A_SAMA301_0 (ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1B)	3bib	T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN-CONTAINING PROTEIN 4 (Mus musculus)	5 / 12	GLY X 8 LEU X 107 GLN X 12 VAL X 14 LEU X 16	None	1.10A	5ubbA-3bibX: undetectable	5ubbA-3bibX: 16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GTQ_B_ACTB207_0 (DUF1778 DOMAIN-CONTAINING PROTEIN N-ACETYLTRANSFERASE)	3bib	T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN-CONTAINING PROTEIN 4 (Mus musculus)	4 / 6	LEU X 109 THR X 80 GLY X 11 ARG X 111	None	1.03A	6gtqB-3bibX: undetectable 6gtqD-3bibX: undetectable	6gtqB-3bibX: 18.56 6gtqD-3bibX: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NCS_A_ACTA303_0 (N-ACETYLNEURAMINIC ACID (SIALIC ACID) SYNTHETASE)	3bib	T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN-CONTAINING PROTEIN 4 (Mus musculus)	3 / 3	ILE X 6 THR X 5 PRO X 17	None	0.65A	6ncsA-3bibX: undetectable	6ncsA-3bibX: 17.12

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4D33_A_MTLA870_0","NITRIC OXIDE SYNTHASE, ENDOTHELIAL","3bib","T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN-CONTAINING PROTEIN 4","Mus musculus",4,"ASN X  28;ILE X  92;ASN X  99;ASP X 100","None;None; NA X 117 ( 3.2A);PSF X 118 ( 2.9A)","1.14A","4d33A-3bibX:undetectable","4d33A-3bibX:11.29"],["5UBB_A_SAMA301_0","ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1B","3bib","T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN-CONTAINING PROTEIN 4","Mus musculus",5,"GLY X   8;LEU X 107;GLN X  12;VAL X  14;LEU X  16","None","1.10A","5ubbA-3bibX:undetectable","5ubbA-3bibX:16.89"],["6GTQ_B_ACTB207_0","DUF1778 DOMAIN-CONTAINING PROTEIN;N-ACETYLTRANSFERASE","3bib","T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN-CONTAINING PROTEIN 4","Mus musculus",4,"LEU X 109;THR X  80;GLY X  11;ARG X 111","None","1.03A","6gtqB-3bibX:undetectable;6gtqD-3bibX:undetectable","6gtqB-3bibX:18.56;6gtqD-3bibX:15.52"],["6NCS_A_ACTA303_0","N-ACETYLNEURAMINIC ACID (SIALIC ACID) SYNTHETASE","3bib","T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN-CONTAINING PROTEIN 4","Mus musculus",3,"ILE X   6;THR X   5;PRO X  17","None","0.65A","6ncsA-3bibX:undetectable","6ncsA-3bibX:17.12"]]