SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		5 / 12 VAL A  44
LEU A 117
ALA A 125
LEU A  40
ALA A 109
 None
 1.18A 1sa1C-3bifA:
undetectable
1sa1D-3bifA:
undetectable		 1sa1C-3bifA:
22.33
1sa1D-3bifA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		5 / 12 THR A  39
LEU A  40
ILE A  41
VAL A 154
ASN A 131
 None
 1.24A 1wsvA-3bifA:
undetectable		 1wsvA-3bifA:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		8 / 12 LYS A  51
THR A  52
ASN A  73
ARG A  79
PHE A  91
ARG A 102
ARG A 193
TYR A 197
 SIN  A 505 (-4.8A)
None
None
None
SIN  A 505 (-4.8A)
BOG  A 510 (-3.1A)
SIN  A 505 (-4.6A)
BOG  A 510 ( 4.2A)
 0.95A 2axnA-3bifA:
33.9		 2axnA-3bifA:
62.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		5 / 12 PRO A  47
GLY A  75
ARG A  78
ALA A 129
THR A 130
 None
SIN  A 505 (-3.5A)
SIN  A 505 (-3.7A)
SIN  A 505 ( 3.9A)
SIN  A 505 (-3.1A)
 1.39A 2axnA-3bifA:
33.9		 2axnA-3bifA:
62.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		9 / 12 PRO A  47
LYS A  51
THR A  52
ASN A  73
ARG A  79
PHE A  91
THR A 130
ARG A 193
TYR A 197
 None
SIN  A 505 (-4.8A)
None
None
None
SIN  A 505 (-4.8A)
SIN  A 505 (-3.1A)
SIN  A 505 (-4.6A)
BOG  A 510 ( 4.2A)
 0.84A 2axnA-3bifA:
33.9		 2axnA-3bifA:
62.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		10 / 12 PRO A  47
THR A  52
ASN A  73
GLY A  75
ARG A  79
PHE A  91
ALA A 129
THR A 130
ARG A 193
TYR A 197
 None
None
None
SIN  A 505 (-3.5A)
None
SIN  A 505 (-4.8A)
SIN  A 505 ( 3.9A)
SIN  A 505 (-3.1A)
SIN  A 505 (-4.6A)
BOG  A 510 ( 4.2A)
 0.65A 2axnA-3bifA:
33.9		 2axnA-3bifA:
62.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		9 / 12 THR A  52
ASN A  73
GLY A  75
ARG A  79
PHE A  91
ARG A 102
ALA A 129
ARG A 193
TYR A 197
 None
None
SIN  A 505 (-3.5A)
None
SIN  A 505 (-4.8A)
BOG  A 510 (-3.1A)
SIN  A 505 ( 3.9A)
SIN  A 505 (-4.6A)
BOG  A 510 ( 4.2A)
 0.76A 2axnA-3bifA:
33.9		 2axnA-3bifA:
62.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		4 / 7 TYR A  85
PHE A  90
ARG A 193
ARG A  78
 None
None
SIN  A 505 (-4.6A)
SIN  A 505 (-3.7A)
 1.49A 2qmqA-3bifA:
2.1		 2qmqA-3bifA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		4 / 6 VAL A 126
LEU A 107
ILE A  54
ILE A  41
 None
 0.91A 3gcsA-3bifA:
undetectable		 3gcsA-3bifA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		5 / 10 VAL A 387
LEU A 372
VAL A 322
VAL A 375
LEU A 397
 BOG  A 525 ( 4.8A)
None
None
BOG  A 525 (-3.8A)
None
 0.99A 3gwxA-3bifA:
undetectable		 3gwxA-3bifA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		4 / 6 GLU A 363
ILE A 326
GLU A 325
ASN A 324
 None
None
PO4  A 515 ( 3.8A)
None
 1.01A 3pgyA-3bifA:
undetectable
3pgyB-3bifA:
2.1		 3pgyA-3bifA:
21.61
3pgyB-3bifA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		3 / 3 ASP A 128
VAL A 124
ASN A 131
 None
 0.74A 4lmnA-3bifA:
undetectable		 4lmnA-3bifA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		4 / 4 ILE A 140
VAL A 126
VAL A  42
ARG A 137
 BOG  A 510 (-4.5A)
None
None
None
 1.35A 4m6tA-3bifA:
undetectable		 4m6tA-3bifA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		3 / 3 ARG A 193
ASP A 189
ARG A  78
 SIN  A 505 (-4.6A)
None
SIN  A 505 (-3.7A)
 0.91A 4mx0A-3bifA:
undetectable		 4mx0A-3bifA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		3 / 3 LEU A 420
THR A 443
ASN A 442
 None
 0.58A 6baaE-3bifA:
2.1		 6baaE-3bifA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		3 / 3 LEU A 420
THR A 443
ASN A 442
 None
 0.58A 6baaF-3bifA:
2.4		 6baaF-3bifA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		3 / 3 LEU A 420
THR A 443
ASN A 442
 None
 0.59A 6baaG-3bifA:
2.6		 6baaG-3bifA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)
(Rattus
norvegicus) 		3 / 3 LEU A 420
THR A 443
ASN A 442
 None
 0.59A 6baaH-3bifA:
undetectable		 6baaH-3bifA:
15.15