SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		6 / 12 GLY A  35
ALA A  10
ILE A  82
VAL A  68
GLY A  13
ILE A  57
 None
 1.12A 1hshA-3bioA:
undetectable		 1hshA-3bioA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		3 / 3 ASP A 205
HIS A 156
ASP A 211
 None
 0.58A 1nw5A-3bioA:
2.9		 1nw5A-3bioA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		4 / 5 GLY A 151
PRO A 256
ALA A 257
ILE A 253
 None
ACT  A3001 ( 4.1A)
None
None
 0.90A 2aofA-3bioA:
undetectable		 2aofA-3bioA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		3 / 3 VAL A 221
ASP A 222
GLU A 188
 None
 0.71A 2qeuA-3bioA:
undetectable		 2qeuA-3bioA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		3 / 3 VAL A 221
ASP A 222
GLU A 188
 None
 0.71A 2qeuC-3bioA:
undetectable		 2qeuC-3bioA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		4 / 7 PRO A 256
MET A 152
GLY A 149
PRO A 150
 ACT  A3001 ( 4.1A)
None
None
None
 1.40A 3ucbB-3bioA:
undetectable		 3ucbB-3bioA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		5 / 12 ILE A  33
ILE A  87
ALA A  66
LEU A  25
LEU A  22
 None
 0.78A 4o1zA-3bioA:
undetectable		 4o1zA-3bioA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		4 / 4 PHE A  93
ASP A  94
GLY A  98
SER A  72
 None
EPE  A1001 (-4.5A)
None
None
 1.16A 4xp9C-3bioA:
undetectable		 4xp9C-3bioA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		4 / 5 ARG A 272
GLN A 273
PRO A 284
ILE A 286
 None
 1.48A 4z4hA-3bioA:
3.5		 4z4hA-3bioA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		6 / 12 GLY A  35
ALA A  10
ILE A  82
VAL A  68
GLY A  13
ILE A  57
 None
 1.12A 5e5kA-3bioA:
undetectable		 5e5kA-3bioA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		6 / 12 GLY A  35
ALA A  10
ILE A  82
VAL A  68
GLY A  13
ILE A  57
 None
 1.13A 5t8hB-3bioA:
undetectable		 5t8hB-3bioA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Porphyromonas
gingivalis) 		5 / 11 VAL A  68
ALA A  66
LEU A 102
ALA A  90
LEU A 263
 None
 1.40A 6dk1B-3bioA:
undetectable		 6dk1B-3bioA:
22.52