SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3biw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		5 / 10 GLY A 284
VAL A 287
ILE A 199
TYR A 230
GLY A 201
 None
 1.41A 1fohC-3biwA:
undetectable		 1fohC-3biwA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		5 / 10 GLY A 284
VAL A 287
ILE A 199
TYR A 230
GLY A 201
 None
 1.43A 1fohD-3biwA:
undetectable		 1fohD-3biwA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		5 / 10 GLY A 284
VAL A 287
ILE A 199
TYR A 230
GLY A 201
 None
 1.41A 1pn0C-3biwA:
undetectable		 1pn0C-3biwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		5 / 10 GLY A 284
VAL A 287
ILE A 199
TYR A 230
GLY A 201
 None
 1.41A 1pn0D-3biwA:
undetectable		 1pn0D-3biwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 7 HIS A 483
TYR A 443
ASN A 635
LEU A 452
 None
 1.11A 1qzrB-3biwA:
undetectable		 1qzrB-3biwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 6 TYR A 504
ASP A 571
ASN A 573
GLU A 528
 None
 1.05A 1rjdA-3biwA:
2.6		 1rjdA-3biwA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 6 TYR A 504
ASP A 571
ASN A 573
GLU A 528
 None
 1.02A 1rjdB-3biwA:
undetectable		 1rjdB-3biwA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 6 TYR A 504
ASP A 571
ASN A 573
GLU A 528
 None
 1.03A 1rjdC-3biwA:
2.6		 1rjdC-3biwA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		3 / 3 LEU A 604
LEU A 405
MET A 404
 None
 0.81A 2itzA-3biwA:
undetectable		 2itzA-3biwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		5 / 12 LEU A 350
ALA A 244
SER A 239
ALA A 337
ASP A 346
 None
 1.04A 3axtA-3biwA:
undetectable		 3axtA-3biwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		3 / 3 GLY A 279
GLY A 201
GLY A 283
 None
 0.43A 3bogC-3biwA:
undetectable		 3bogC-3biwA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		5 / 6 GLY A 279
GLY A 283
GLY A 201
GLY A 281
GLY A 202
 None
 0.91A 3bogB-3biwA:
0.0
3bogD-3biwA:
0.0		 3bogB-3biwA:
undetectable
3bogD-3biwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		5 / 10 ILE A 265
ILE A 224
PRO A  53
VAL A  55
LEU A 156
 None
 1.26A 3elzB-3biwA:
undetectable		 3elzB-3biwA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		5 / 12 THR A 318
LEU A 625
TYR A 372
VAL A 630
ILE A 456
 None
 1.08A 3frqA-3biwA:
undetectable		 3frqA-3biwA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		3 / 3 TRP A 485
ALA A 314
VAL A 407
 None
 0.89A 3l8lC-3biwA:
undetectable
3l8lD-3biwA:
undetectable		 3l8lC-3biwA:
3.93
3l8lD-3biwA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 5 ILE A  62
THR A  57
THR A  56
PHE A 268
 None
 1.19A 3snfA-3biwA:
undetectable		 3snfA-3biwA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		5 / 12 ILE A 121
GLY A 202
SER A 203
SER A 280
LEU A 533
 None
 1.13A 3v8vA-3biwA:
undetectable		 3v8vA-3biwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 8 LEU A 211
VAL A 142
VAL A 146
GLN A 149
 None
 1.01A 4em2A-3biwA:
undetectable		 4em2A-3biwA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		3 / 3 PHE A 438
VAL A 426
ILE A 419
 None
 0.36A 4emaA-3biwA:
undetectable		 4emaA-3biwA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		3 / 3 LYS A 474
ARG A 473
TRP A 520
 None
 1.30A 4i90A-3biwA:
1.0		 4i90A-3biwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 5 TYR A 506
LEU A 290
THR A 276
MET A 196
 None
 1.41A 4mbsB-3biwA:
undetectable		 4mbsB-3biwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 5 TYR A 618
ARG A 619
GLU A 411
VAL A 129
 None
 1.33A 4nkvB-3biwA:
undetectable		 4nkvB-3biwA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 5 ILE A 535
PRO A 530
HIS A 525
VAL A 142
 None
 1.33A 4s0vA-3biwA:
undetectable		 4s0vA-3biwA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 6 GLY A 425
GLU A 470
ASP A 430
ASP A 424
 None
 0.94A 4uckB-3biwA:
undetectable		 4uckB-3biwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		3 / 3 ASP A 421
ARG A 472
PRO A 469
 None
 0.78A 4wanC-3biwA:
undetectable		 4wanC-3biwA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		3 / 3 ILE A 385
PRO A 386
ILE A 380
 None
 0.39A 5hw8F-3biwA:
undetectable		 5hw8F-3biwA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 7 ASP A 522
ALA A 524
LYS A 414
GLU A 417
 None
 0.89A 6ci6A-3biwA:
2.6		 6ci6A-3biwA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		5 / 7 VAL A 197
ILE A 158
GLY A  75
ARG A 311
ALA A 218
 None
 1.41A 6hd6B-3biwA:
undetectable		 6hd6B-3biwA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 4 ASP A 213
ILE A 535
PRO A 530
LEU A 533
 None
 1.33A 6mkeB-3biwA:
undetectable		 6mkeB-3biwA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3biw NEUROLIGIN-1
(Rattus
norvegicus) 		4 / 4 ASP A 213
ILE A 535
PRO A 530
LEU A 533
 None
 1.29A 6mkeA-3biwA:
undetectable		 6mkeA-3biwA:
8.45