SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bji'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 8 CYH A 546
HIS A 516
CYH A 564
GLY A 565
 ZN  A   4 (-2.0A)
ZN  A   4 (-3.1A)
ZN  A   4 (-2.4A)
None
 0.97A 1ekjA-3bjiA:
undetectable
1ekjB-3bjiA:
undetectable		 1ekjA-3bjiA:
19.25
1ekjB-3bjiA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 5 ASP A 376
VAL A 373
SER A 285
GLN A 542
 None
 1.24A 1n2xB-3bjiA:
undetectable		 1n2xB-3bjiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 8 ILE A 433
LEU A 431
MET A 496
LYS A 492
 None
 0.99A 1os6A-3bjiA:
undetectable		 1os6A-3bjiA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 8 ILE A 433
LEU A 431
MET A 496
LYS A 492
 None
 1.04A 3selX-3bjiA:
undetectable		 3selX-3bjiA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 6 ASP A 376
THR A 384
ILE A 383
THR A 539
 None
 1.07A 4acbC-3bjiA:
undetectable		 4acbC-3bjiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		4 / 7 ASN A 448
LEU A 427
ILE A 503
ILE A 506
 None
 0.66A 4ojbA-3bjiA:
undetectable		 4ojbA-3bjiA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		3 / 3 SER A 291
ASP A 211
ASP A 324
 None
 0.81A 4uckA-3bjiA:
undetectable		 4uckA-3bjiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 12 TYR A 541
HIS A 554
CYH A 529
CYH A 557
LEU A 536
 None
ZN  A   1 (-3.2A)
ZN  A   1 (-2.1A)
ZN  A   1 (-2.1A)
None
 1.18A 5lsuA-3bjiA:
undetectable		 5lsuA-3bjiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 12 PHE A 521
HIS A 554
THR A 527
CYH A 532
LEU A 536
 None
ZN  A   1 (-3.2A)
None
ZN  A   1 (-2.2A)
None
 1.24A 5lsuB-3bjiA:
undetectable		 5lsuB-3bjiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		3 / 3 TYR A 280
ASN A 239
LEU A 243
 None
 0.79A 6b58A-3bjiA:
undetectable		 6b58A-3bjiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3bji PROTO-ONCOGENE VAV
(Homo
sapiens) 		5 / 10 LEU A 278
LEU A 535
THR A 539
VAL A 373
CYH A 369
 None
 1.18A 6czmE-3bjiA:
undetectable
6czmF-3bjiA:
undetectable		 6czmE-3bjiA:
20.94
6czmF-3bjiA:
20.94