SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bjr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		5 / 12 PHE A 190
GLY A 149
LEU A  53
ALA A 256
PHE A  57
 None
 1.26A 1gseA-3bjrA:
undetectable		 1gseA-3bjrA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 4 HIS A  20
ALA A  58
PHE A  57
GLY A  61
 None
 0.86A 1mj2B-3bjrA:
undetectable		 1mj2B-3bjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 4 HIS A  20
ALA A  58
PHE A  57
GLY A  61
 None
 0.85A 1mj2D-3bjrA:
undetectable		 1mj2D-3bjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 4 HIS A  20
ALA A  58
PHE A  57
GLY A  61
 None
 0.84A 1mjoB-3bjrA:
undetectable		 1mjoB-3bjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 4 HIS A  20
ALA A  58
PHE A  57
GLY A  61
 None
 0.85A 1mjoA-3bjrA:
undetectable		 1mjoA-3bjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 4 HIS A  20
ALA A  58
PHE A  57
GLY A  61
 None
 0.84A 1mjoD-3bjrA:
undetectable		 1mjoD-3bjrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		6 / 12 LEU A  15
GLY A  87
VAL A 136
LEU A 134
LEU A 141
LEU A  93
 None
 1.42A 1mx1D-3bjrA:
17.1		 1mx1D-3bjrA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		5 / 12 LEU A  67
GLY A  87
VAL A 136
LEU A 134
LEU A 141
 None
 0.95A 1mx1D-3bjrA:
17.1		 1mx1D-3bjrA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		5 / 12 GLY A  87
VAL A 136
LEU A 134
LEU A 141
LEU A  93
 None
 0.79A 1mx1F-3bjrA:
17.3		 1mx1F-3bjrA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 6 ASP A 179
TYR A 208
ASN A 186
GLU A 175
 None
 1.19A 1rjdA-3bjrA:
undetectable		 1rjdA-3bjrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 6 ASP A 179
TYR A 208
ASN A 186
GLU A 175
 None
 1.20A 1rjdB-3bjrA:
undetectable		 1rjdB-3bjrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 6 ASP A 179
TYR A 208
ASN A 186
GLU A 175
 None
 1.22A 1rjdC-3bjrA:
undetectable		 1rjdC-3bjrA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 7 PHE A 190
LEU A 253
ALA A 256
PHE A  57
 None
 1.10A 2vcvA-3bjrA:
undetectable		 2vcvA-3bjrA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 8 LEU A   8
ARG A  88
GLY A  87
ALA A  89
 None
 0.89A 2xfsA-3bjrA:
undetectable		 2xfsA-3bjrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 8 LEU A   8
ARG A  88
GLY A  87
ALA A  89
 None
 0.89A 2xh9A-3bjrA:
undetectable		 2xh9A-3bjrA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 7 LEU A  15
LEU A  67
PRO A 109
ILE A  35
 None
 0.72A 3s56B-3bjrA:
undetectable		 3s56B-3bjrA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 8 ASP A 196
GLY A 227
VAL A 152
SER A  41
 None
 0.92A 4acbB-3bjrA:
4.3
4acbC-3bjrA:
4.2		 4acbB-3bjrA:
19.12
4acbC-3bjrA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		5 / 12 TYR A  18
VAL A  47
ALA A  48
GLY A  17
SER A  52
 None
GOL  A 265 (-3.9A)
GOL  A 265 (-3.3A)
None
None
 1.12A 4mm8A-3bjrA:
undetectable		 4mm8A-3bjrA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		5 / 10 TYR A  18
VAL A  47
ALA A  48
GLY A  17
SER A  52
 None
GOL  A 265 (-3.9A)
GOL  A 265 (-3.3A)
None
None
 1.08A 4mmdA-3bjrA:
undetectable		 4mmdA-3bjrA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		5 / 12 TYR A  18
VAL A  47
ALA A  48
GLY A  17
SER A  52
 None
GOL  A 265 (-3.9A)
GOL  A 265 (-3.3A)
None
None
 1.06A 4mmdB-3bjrA:
undetectable		 4mmdB-3bjrA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		5 / 12 ALA A  50
LEU A  53
ALA A  54
PHE A  57
THR A  16
 None
 0.62A 5k9dA-3bjrA:
undetectable		 5k9dA-3bjrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		3 / 3 ILE A 118
VAL A  37
PRO A 109
 None
 0.70A 5uunA-3bjrA:
undetectable		 5uunA-3bjrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3bjr PUTATIVE
CARBOXYLESTERASE
(Lactobacillus
plantarum) 		4 / 7 HIS A 117
LEU A  80
TYR A  42
VAL A  83
 None
 1.18A 6g2pA-3bjrA:
undetectable		 6g2pA-3bjrA:
21.48