SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bjs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 8 GLU A 259
ILE A 348
LEU A 351
ALA A 172
VAL A 386
 MG  A 501 (-3.5A)
None
None
None
None
 1.22A 1a29A-3bjsA:
undetectable		 1a29A-3bjsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 ILE A 316
GLY A  84
GLY A 142
SER A 141
VAL A 398
 None
 0.85A 1i9gA-3bjsA:
undetectable		 1i9gA-3bjsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 GLU A 260
ILE A 177
MET A  59
ARG A  67
GLU A 361
 None
 1.40A 1ki3A-3bjsA:
undetectable		 1ki3A-3bjsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 11 ALA A  86
ILE A 140
GLY A 314
GLY A 315
ILE A  72
 None
 1.04A 1sduA-3bjsA:
undetectable		 1sduA-3bjsA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 10 ALA A  86
ILE A 140
GLY A 314
GLY A 315
ILE A  72
 None
 0.95A 1sdvA-3bjsA:
undetectable		 1sdvA-3bjsA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		6 / 12 ALA A  86
GLY A 314
GLY A 315
ILE A 316
VAL A  74
ILE A  72
 None
 1.23A 2fxeA-3bjsA:
undetectable		 2fxeA-3bjsA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 GLY A 314
LEU A 132
GLY A 135
LEU A 127
LEU A  98
 None
 0.94A 2nxeA-3bjsA:
undetectable		 2nxeA-3bjsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 GLY A 314
LEU A 132
GLY A 135
LEU A 127
LEU A  98
 None
 0.95A 2nxeB-3bjsA:
undetectable		 2nxeB-3bjsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 ALA A  86
GLY A 314
GLY A 315
ILE A 316
ILE A  72
 None
 0.96A 2o4kA-3bjsA:
undetectable		 2o4kA-3bjsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 ALA A  86
ILE A 140
GLY A 314
GLY A 315
ILE A  72
 None
 0.99A 2o4kA-3bjsA:
undetectable		 2o4kA-3bjsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 GLY A 314
LEU A 132
GLY A 135
LEU A 127
LEU A  98
 None
 0.93A 2zbpA-3bjsA:
undetectable		 2zbpA-3bjsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		3 / 3 ARG A  90
GLU A 286
TYR A 289
 None
MG  A 501 (-2.5A)
None
 0.84A 3k37B-3bjsA:
undetectable		 3k37B-3bjsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 PHE A 294
GLY A 319
ALA A 323
ILE A 282
MET A 297
 None
 1.14A 3ld6A-3bjsA:
undetectable		 3ld6A-3bjsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 PHE A 294
GLY A 319
ALA A 323
ILE A 331
MET A 297
 None
 1.15A 3ld6A-3bjsA:
undetectable		 3ld6A-3bjsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		3 / 3 GLY A 285
TRP A 306
VAL A 303
 None
 0.62A 3n62B-3bjsA:
undetectable		 3n62B-3bjsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		3 / 3 GLY A 285
TRP A 306
VAL A 303
 None
 0.60A 3n65B-3bjsA:
undetectable		 3n65B-3bjsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		3 / 3 GLY A 285
TRP A 306
VAL A 303
 None
 0.64A 3n66B-3bjsA:
undetectable		 3n66B-3bjsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		6 / 10 ALA A  86
ILE A 140
GLY A 315
ILE A 316
VAL A  74
ILE A  72
 None
 1.35A 3nu6A-3bjsA:
undetectable		 3nu6A-3bjsA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 6 LEU A 250
ASP A 229
LEU A 231
THR A 232
 None
 0.99A 3rozA-3bjsA:
undetectable		 3rozA-3bjsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 5 GLU A 286
GLY A 285
TYR A 289
GLU A 293
 MG  A 501 (-2.5A)
None
None
None
 1.41A 3w9tA-3bjsA:
undetectable		 3w9tA-3bjsA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 5 GLU A 286
GLY A 285
TYR A 289
GLU A 293
 MG  A 501 (-2.5A)
None
None
None
 1.40A 3w9tC-3bjsA:
undetectable		 3w9tC-3bjsA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 5 GLU A 286
GLY A 285
TYR A 289
GLU A 293
 MG  A 501 (-2.5A)
None
None
None
 1.40A 3w9tD-3bjsA:
undetectable		 3w9tD-3bjsA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 5 GLU A 286
GLY A 285
TYR A 289
GLU A 293
 MG  A 501 (-2.5A)
None
None
None
 1.40A 3w9tG-3bjsA:
undetectable		 3w9tG-3bjsA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 11 ILE A 143
ILE A 140
GLY A 314
SER A  91
GLY A 135
 None
 0.91A 4ac9B-3bjsA:
undetectable
4ac9C-3bjsA:
undetectable		 4ac9B-3bjsA:
20.30
4ac9C-3bjsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 8 GLY A  82
VAL A  74
ILE A  71
PHE A 374
 None
 0.81A 4fglD-3bjsA:
undetectable		 4fglD-3bjsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 7 GLY A  82
VAL A  74
ILE A  71
PHE A 374
 None
 0.89A 4fglC-3bjsA:
undetectable		 4fglC-3bjsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 8 GLY A 285
GLU A 259
TYR A 270
VAL A 305
 None
MG  A 501 (-3.5A)
None
None
 0.85A 4fgzA-3bjsA:
undetectable		 4fgzA-3bjsA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 7 ILE A 320
LEU A 163
LYS A 153
GLY A 152
 None
 0.99A 4hbfA-3bjsA:
undetectable		 4hbfA-3bjsA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 7 GLU A 361
ASP A 233
ASN A 235
ILE A 177
 None
MG  A 501 (-2.9A)
MG  A 501 ( 4.3A)
None
 1.27A 4ii8A-3bjsA:
undetectable		 4ii8A-3bjsA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 GLY A  82
VAL A 398
LEU A 342
GLU A 400
ILE A  72
 None
 1.10A 4pd9A-3bjsA:
undetectable		 4pd9A-3bjsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		6 / 12 ALA A  86
ILE A 140
GLY A 315
ILE A 316
VAL A  74
ILE A  72
 None
 1.35A 4q1xB-3bjsA:
undetectable		 4q1xB-3bjsA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 8 LEU A 147
ALA A 112
MET A  37
ILE A  39
 None
 0.57A 4wboB-3bjsA:
undetectable		 4wboB-3bjsA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		5 / 12 VAL A 249
VAL A 217
ILE A 253
ILE A 206
GLY A 207
 None
 1.00A 4y8wC-3bjsA:
undetectable		 4y8wC-3bjsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		4 / 5 TYR A 289
LYS A 312
GLU A 286
GLY A 285
 None
None
MG  A 501 (-2.5A)
None
 1.20A 5jhdJ-3bjsA:
undetectable		 5jhdJ-3bjsA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		3 / 3 THR A  56
SER A  63
ASP A 208
 None
 0.66A 5kvaA-3bjsA:
undetectable		 5kvaA-3bjsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		3 / 3 THR A  56
SER A  63
ASP A 208
 None
 0.65A 5kvaB-3bjsA:
undetectable		 5kvaB-3bjsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3bjs MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Polaromonas
sp.
JS666) 		3 / 3 GLY A 285
TRP A 306
VAL A 303
 None
 0.59A 5vuoB-3bjsA:
undetectable		 5vuoB-3bjsA:
22.20