SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bjx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 8 LEU A  42
GLY A 260
LEU A 124
TYR A  48
 None
 0.80A 1jlbA-3bjxA:
undetectable		 1jlbA-3bjxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 4 ALA A  68
ARG A 227
GLN A  67
GLU A  71
 None
 1.29A 1lqtB-3bjxA:
undetectable		 1lqtB-3bjxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 4 ALA A  68
ARG A 227
GLN A  67
GLU A  71
 None
 1.29A 1lquB-3bjxA:
undetectable		 1lquB-3bjxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 8 LEU A  42
GLY A 260
LEU A 124
TYR A  48
 None
 0.77A 1s1xA-3bjxA:
undetectable		 1s1xA-3bjxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		6 / 10 ALA A  65
ALA A  68
LEU A  72
LEU A 119
ALA A 228
SER A  56
 None
 1.43A 2bxgB-3bjxA:
undetectable		 2bxgB-3bjxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 6 TYR A  48
TYR A 265
GLN A 266
ILE A 121
 None
 0.93A 2pgzD-3bjxA:
undetectable
2pgzE-3bjxA:
undetectable		 2pgzD-3bjxA:
19.87
2pgzE-3bjxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 7 GLN A  12
TYR A  23
TYR A 265
ILE A 121
 None
 1.30A 2ph9A-3bjxA:
undetectable
2ph9B-3bjxA:
undetectable		 2ph9A-3bjxA:
19.87
2ph9B-3bjxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 8 ASP A 189
TYR A 217
HIS A 183
HIS A 181
 SO4  A 297 (-3.7A)
None
None
None
 1.38A 2v0gA-3bjxA:
undetectable		 2v0gA-3bjxA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 6 LEU A 208
THR A 204
PHE A 190
ASP A 271
 None
 1.10A 2wm3A-3bjxA:
undetectable		 2wm3A-3bjxA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 6 ASP A  97
ILE A 100
LEU A 283
GLU A  88
 None
 0.94A 2ya7A-3bjxA:
undetectable		 2ya7A-3bjxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 6 ASP A  97
ILE A 100
LEU A 283
GLU A  88
 None
 0.87A 2ya7B-3bjxA:
undetectable		 2ya7B-3bjxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 6 ASP A  97
ILE A 100
LEU A 283
GLU A  88
 None
 0.91A 2ya7D-3bjxA:
undetectable		 2ya7D-3bjxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 7 VAL A 103
ASP A 284
LEU A 107
ILE A 202
 None
 0.91A 3avpA-3bjxA:
undetectable		 3avpA-3bjxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_A_DX2A271_1
(PTERIDINE REDUCTASE
1)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		5 / 10 SER A 292
PHE A 294
VAL A 106
LEU A 158
PRO A  33
 None
 1.50A 3jq7A-3bjxA:
0.0		 3jq7A-3bjxA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		5 / 9 ILE A 279
THR A 280
LEU A 107
VAL A 103
LEU A  86
 None
 1.22A 4g1bC-3bjxA:
undetectable		 4g1bC-3bjxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		4 / 8 ALA A  52
PRO A  50
LEU A 120
LEU A 124
 None
 0.97A 4jjkA-3bjxA:
undetectable		 4jjkA-3bjxA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		5 / 11 LEU A  72
ARG A  73
SER A  76
LEU A 119
LEU A 224
 None
 1.31A 4or0A-3bjxA:
1.7		 4or0A-3bjxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		5 / 12 TYR A  23
ILE A 272
PHE A 268
LEU A 193
GLN A 191
 None
None
SO4  A 297 (-4.8A)
None
None
 1.44A 5l8oB-3bjxA:
undetectable		 5l8oB-3bjxA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		5 / 11 ILE A 279
ILE A 276
PHE A 110
VAL A 203
ALA A 192
 None
 1.15A 5lg3A-3bjxA:
undetectable		 5lg3A-3bjxA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3bjx HALOCARBOXYLIC ACID
DEHALOGENASE DEHI
(Pseudomonas
putida) 		5 / 12 GLU A 126
VAL A 133
LEU A  30
ALA A 239
PRO A 236
 None
 1.12A 5syeB-3bjxA:
undetectable		 5syeB-3bjxA:
20.14