SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 8 PHE A  56
GLY A  50
LEU A  97
VAL A 129
 None
 0.91A 1gsfC-3bkwA:
undetectable		 1gsfC-3bkwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 11 LEU A 133
ALA A  65
VAL A 129
LEU A 125
LEU A  49
 None
 1.18A 1rlbF-3bkwA:
undetectable		 1rlbF-3bkwA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  50
GLY A  52
LEU A  73
ASP A  96
SER A 113
 None
 0.97A 1xdsA-3bkwA:
15.3		 1xdsA-3bkwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  50
GLY A  52
LEU A  73
ASP A  96
SER A 113
 None
 0.93A 1xdsB-3bkwA:
15.8		 1xdsB-3bkwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 7 LEU A 102
VAL A 129
THR A 128
VAL A 119
 None
 0.93A 2qblA-3bkwA:
undetectable		 2qblA-3bkwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 7 GLY A  52
ASP A  72
ASP A  96
LEU A  97
 None
 0.69A 2uyqA-3bkwA:
12.3		 2uyqA-3bkwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 8 SER A 142
PRO A  39
LEU A  44
THR A 196
 None
None
None
EDO  A 243 (-3.0A)
 1.15A 2v0zO-3bkwA:
undetectable		 2v0zO-3bkwA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 8 PHE A 139
SER A 203
ARG A 127
ALA A 110
 None
None
EDO  A 245 (-2.9A)
None
 1.18A 2v7uA-3bkwA:
undetectable		 2v7uA-3bkwA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		3 / 3 LEU A 116
VAL A 193
ARG A 191
 None
None
EDO  A 243 ( 3.8A)
 0.74A 3b0wB-3bkwA:
undetectable		 3b0wB-3bkwA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  50
GLY A  52
ASP A  96
LEU A  97
TYR A 118
 None
 0.71A 3o7wA-3bkwA:
12.3		 3o7wA-3bkwA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  52
SER A  74
MET A  77
ASP A  96
LEU A  97
 None
 0.75A 3ou6A-3bkwA:
17.0		 3ou6A-3bkwA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  52
SER A  74
MET A  77
ASP A  96
LEU A  97
 None
 0.71A 3ou7A-3bkwA:
16.9		 3ou7A-3bkwA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		3 / 3 GLY A  52
ASP A  72
ASP A  96
 None
 0.32A 3ou7C-3bkwA:
16.9		 3ou7C-3bkwA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  52
SER A  74
MET A  77
ASP A  96
LEU A  97
 None
 0.67A 3ou7D-3bkwA:
16.9		 3ou7D-3bkwA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  52
LEU A  73
SER A  74
MET A  77
ASP A  96
 None
 0.70A 3pfgA-3bkwA:
15.7		 3pfgA-3bkwA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  50
GLY A  52
LEU A  73
SER A  74
VAL A 119
 None
 0.88A 4htfB-3bkwA:
17.4		 4htfB-3bkwA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		6 / 12 GLY A  50
GLY A  52
ASP A  72
MET A  77
ASP A  96
ALA A 115
 None
 0.42A 4iv8A-3bkwA:
18.8		 4iv8A-3bkwA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		6 / 12 GLY A  50
GLY A  52
ASP A  72
MET A  77
ASP A  96
ALA A 115
 None
 0.41A 4iv8B-3bkwA:
18.9		 4iv8B-3bkwA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  50
GLY A  52
LEU A  73
SER A  74
ASP A  96
 None
 0.62A 4krhA-3bkwA:
18.3		 4krhA-3bkwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 ASP A  48
GLY A  50
ASP A  72
LEU A  73
ASP A  96
 None
 0.88A 4pghB-3bkwA:
15.1		 4pghB-3bkwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  50
GLY A  52
SER A  74
MET A  77
ALA A 115
 None
 0.80A 4qtuB-3bkwA:
17.3		 4qtuB-3bkwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		6 / 12 GLY A  50
GLY A  52
SER A  74
MET A  77
SER A 113
ALA A 115
 None
 1.33A 4qtuD-3bkwA:
17.9		 4qtuD-3bkwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		3 / 3 THR A 216
ASP A 217
ALA A 218
 None
 0.06A 5g5gB-3bkwA:
undetectable		 5g5gB-3bkwA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		3 / 3 VAL A 129
SER A 112
MET A  37
 None
 0.90A 5ikqA-3bkwA:
undetectable		 5ikqA-3bkwA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		3 / 3 HIS A  63
GLU A  62
TRP A  59
 EDO  A 249 (-4.3A)
None
None
 0.82A 5odiD-3bkwA:
undetectable		 5odiD-3bkwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		3 / 3 HIS A  63
GLU A  62
TRP A  59
 EDO  A 249 (-4.3A)
None
None
 0.70A 5odqD-3bkwA:
2.8		 5odqD-3bkwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		3 / 3 HIS A  63
GLU A  62
TRP A  59
 EDO  A 249 (-4.3A)
None
None
 0.72A 5odrD-3bkwA:
2.8		 5odrD-3bkwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 7 THR A 196
HIS A 145
PRO A 146
ILE A 147
 EDO  A 243 (-3.0A)
None
None
None
 1.18A 5vkqA-3bkwA:
undetectable
5vkqB-3bkwA:
undetectable		 5vkqA-3bkwA:
9.81
5vkqB-3bkwA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 8 THR A 196
HIS A 145
PRO A 146
ILE A 147
 EDO  A 243 (-3.0A)
None
None
None
 1.14A 5vkqB-3bkwA:
undetectable
5vkqC-3bkwA:
undetectable		 5vkqB-3bkwA:
9.81
5vkqC-3bkwA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 7 THR A 196
HIS A 145
PRO A 146
ILE A 147
 EDO  A 243 (-3.0A)
None
None
None
 1.15A 5vkqC-3bkwA:
undetectable
5vkqD-3bkwA:
undetectable		 5vkqC-3bkwA:
9.81
5vkqD-3bkwA:
9.81