SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		3 / 4 VAL A 156
TRP A 159
TRP A  38
 None
 1.30A 1gmkC-3bkxA:
undetectable
1gmkD-3bkxA:
undetectable		 1gmkC-3bkxA:
5.52
1gmkD-3bkxA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		6 / 12 GLY A  50
GLY A  52
ILE A  75
ALA A  76
SER A 130
TYR A 133
 None
 0.96A 1ri4A-3bkxA:
13.1		 1ri4A-3bkxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 8 SER A 130
LEU A 201
PHE A 144
PHE A 274
 None
 0.95A 1wrlC-3bkxA:
undetectable
1wrlD-3bkxA:
undetectable		 1wrlC-3bkxA:
13.65
1wrlD-3bkxA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		3 / 3 LYS A   1
ASP A 220
ASP A 225
 None
 1.09A 2br4A-3bkxA:
6.7		 2br4A-3bkxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 12 THR A  28
ASP A 155
VAL A 126
ALA A  58
VAL A  40
 None
 1.13A 2g72A-3bkxA:
8.8		 2g72A-3bkxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 9 GLY A 270
ILE A  34
VAL A 126
ILE A  46
VAL A  70
 None
 1.19A 2nnhB-3bkxA:
undetectable		 2nnhB-3bkxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 5 TYR A 133
ARG A 193
THR A 194
LEU A 195
 None
 1.41A 3ag1J-3bkxA:
undetectable		 3ag1J-3bkxA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 8 ASN A 191
ILE A 192
TRP A 132
TYR A 133
 None
 1.34A 3ccfB-3bkxA:
13.8		 3ccfB-3bkxA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 12 GLY A  50
GLY A  52
ILE A  75
ASN A 109
LEU A  56
 None
 0.90A 3ckkA-3bkxA:
8.0		 3ckkA-3bkxA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 12 ILE A  34
ILE A  73
ARG A 124
ASP A 155
LEU A 143
 None
 1.04A 3uj6A-3bkxA:
13.6		 3uj6A-3bkxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 12 LEU A 131
TRP A 159
LEU A 223
LEU A  56
ILE A  34
 None
 1.00A 3uwlB-3bkxA:
undetectable		 3uwlB-3bkxA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 12 LEU A 131
TRP A 159
LEU A 223
LEU A  56
ILE A  34
 None
 1.01A 3uwlD-3bkxA:
undetectable		 3uwlD-3bkxA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 5 THR A 194
ILE A 196
GLU A 158
PHE A 144
 None
 1.33A 4ac9C-3bkxA:
2.5		 4ac9C-3bkxA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 5 THR A 194
ILE A 196
GLU A 158
PHE A 144
 None
 1.37A 4acaC-3bkxA:
2.6		 4acaC-3bkxA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 5 THR A 194
ILE A 196
GLU A 158
PHE A 144
 None
 1.43A 4acbC-3bkxA:
2.2		 4acbC-3bkxA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 12 ALA A 174
LEU A 180
LEU A 181
LEU A 254
MET A 257
 None
 1.08A 4i1rA-3bkxA:
undetectable		 4i1rA-3bkxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 7 ASP A 207
GLN A 203
ASN A 208
ILE A 272
 None
 1.17A 4ii8A-3bkxA:
undetectable		 4ii8A-3bkxA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 11 PHE A 134
ALA A 139
ALA A 141
VAL A 154
LEU A 127
 None
 1.13A 4j6cA-3bkxA:
undetectable		 4j6cA-3bkxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 12 PHE A 134
ALA A 139
ALA A 141
VAL A 154
LEU A 127
 None
 1.11A 4j6dA-3bkxA:
undetectable		 4j6dA-3bkxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 12 PHE A 134
ALA A 139
ALA A 141
VAL A 154
LEU A 127
 None
 1.13A 4j6dB-3bkxA:
undetectable		 4j6dB-3bkxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 12 PHE A 134
ALA A 139
ALA A 141
VAL A 154
LEU A 127
 None
 1.12A 4jbtA-3bkxA:
undetectable		 4jbtA-3bkxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 11 PHE A 134
ALA A 139
ALA A 141
VAL A 154
LEU A 127
 None
 1.12A 4jbtB-3bkxA:
undetectable		 4jbtB-3bkxA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 9 LEU A  94
LEU A  98
GLY A  99
LEU A 102
ALA A  61
 None
 1.13A 5dqfA-3bkxA:
undetectable		 5dqfA-3bkxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		3 / 3 VAL A 104
GLN A  53
CYH A  51
 None
 0.84A 5icxA-3bkxA:
undetectable
5icxE-3bkxA:
undetectable		 5icxA-3bkxA:
19.93
5icxE-3bkxA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		3 / 3 VAL A 104
GLN A  53
CYH A  51
 None
 0.86A 5icxC-3bkxA:
undetectable
5icxF-3bkxA:
undetectable		 5icxC-3bkxA:
19.93
5icxF-3bkxA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		3 / 3 GLY A  52
ASP A  74
ASN A 109
 None
 0.27A 5jglA-3bkxA:
11.9		 5jglA-3bkxA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 10 HIS A  30
LEU A 265
THR A 267
ALA A 266
PRO A 163
 None
 1.25A 5tt3A-3bkxA:
undetectable		 5tt3A-3bkxA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 10 HIS A  30
LEU A 265
THR A 267
ALA A 266
PRO A 163
 None
 1.31A 5tt3C-3bkxA:
undetectable		 5tt3C-3bkxA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 5 TYR A 133
ARG A 193
THR A 194
LEU A 195
 None
 1.17A 5w97J-3bkxA:
undetectable		 5w97J-3bkxA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 5 TYR A 133
ARG A 193
THR A 194
LEU A 195
 None
 1.31A 5x1bW-3bkxA:
undetectable		 5x1bW-3bkxA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 5 TYR A 133
ARG A 193
THR A 194
LEU A 195
 None
 1.19A 5x1fW-3bkxA:
undetectable		 5x1fW-3bkxA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		5 / 12 GLU A  48
ILE A  49
GLY A  50
GLY A  52
ILE A  75
 None
 0.77A 6iftA-3bkxA:
10.9		 6iftA-3bkxA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3bkx SAM-DEPENDENT
METHYLTRANSFERASE
(Lactobacillus
paracasei) 		4 / 5 TYR A 133
ARG A 193
THR A 194
LEU A 195
 None
 1.35A 6nknJ-3bkxA:
undetectable		 6nknJ-3bkxA:
10.62