SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3bl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 9 VAL A  47
GLY A  12
THR A  17
ILE A  51
THR A 185
 None
None
None
None
PO4  A 500 (-3.1A)
 1.36A 1gtnL-3bl5A:
undetectable
1gtnM-3bl5A:
undetectable		 1gtnL-3bl5A:
22.86
1gtnM-3bl5A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		4 / 5 SER A 103
SER A 106
PHE A 136
PHE A 152
 None
 1.19A 1oipA-3bl5A:
undetectable		 1oipA-3bl5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.89A 2f81A-3bl5A:
undetectable		 2f81A-3bl5A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		4 / 6 SER A  16
ASP A  15
SER A  11
VAL A   9
 MG  A 400 (-3.0A)
PO4  A 500 (-3.5A)
MG  A 400 (-3.0A)
None
 1.30A 2hdnI-3bl5A:
undetectable
2hdnJ-3bl5A:
4.3
2hdnL-3bl5A:
undetectable		 2hdnI-3bl5A:
9.59
2hdnJ-3bl5A:
21.43
2hdnL-3bl5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		4 / 6 SER A  11
VAL A   9
SER A  16
ASP A  15
 MG  A 400 (-3.0A)
None
MG  A 400 (-3.0A)
PO4  A 500 (-3.5A)
 1.22A 2hdnJ-3bl5A:
4.3
2hdnK-3bl5A:
undetectable
2hdnL-3bl5A:
undetectable		 2hdnJ-3bl5A:
21.43
2hdnK-3bl5A:
9.59
2hdnL-3bl5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 11 SER A  11
SER A  16
ASN A  98
THR A 119
GLY A 120
 MG  A 400 (-3.0A)
MG  A 400 (-3.0A)
None
None
None
 0.79A 2hmaA-3bl5A:
10.3		 2hmaA-3bl5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.97A 2hs2A-3bl5A:
undetectable		 2hs2A-3bl5A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.90A 2ienA-3bl5A:
undetectable		 2ienA-3bl5A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.94A 2pymA-3bl5A:
undetectable		 2pymA-3bl5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.95A 2pymB-3bl5A:
undetectable		 2pymB-3bl5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.96A 2pynA-3bl5A:
undetectable		 2pynA-3bl5A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.96A 2pynB-3bl5A:
undetectable		 2pynB-3bl5A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.97A 2q63B-3bl5A:
undetectable		 2q63B-3bl5A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 1.01A 3cyxA-3bl5A:
undetectable		 3cyxA-3bl5A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.87A 3d20A-3bl5A:
undetectable		 3d20A-3bl5A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 10 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.86A 4dqfB-3bl5A:
undetectable		 4dqfB-3bl5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		3 / 3 GLY A 196
CYH A 201
CYH A 198
 None
ZN  A 300 (-2.3A)
ZN  A 300 (-2.2A)
 0.92A 5inzB-3bl5A:
undetectable		 5inzB-3bl5A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC
(Bacillus
subtilis) 		5 / 12 LEU A 108
GLY A 113
ALA A 114
VAL A  33
ILE A   7
 None
 0.82A 6dilB-3bl5A:
undetectable		 6dilB-3bl5A:
14.86