SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3blw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 THR A 235
SER A 177
THR A 179
VAL A 181
 None
 0.82A 1ictD-3blwA:
undetectable		 1ictD-3blwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 166
ASP A 208
ILE A 209
ASP A 231
 None
 0.87A 1p7lD-3blwA:
undetectable		 1p7lD-3blwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 166
ASP A 208
ILE A 209
ASP A 231
 None
 0.88A 1p7lC-3blwA:
undetectable		 1p7lC-3blwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 260
PHE A 262
ALA A 267
VAL A  36
LEU A  22
 None
 1.17A 1rbpA-3blwA:
undetectable		 1rbpA-3blwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 166
ASP A 208
ILE A 209
ASP A 231
 None
 0.92A 1rg9B-3blwA:
undetectable		 1rg9B-3blwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 166
ASP A 208
ILE A 209
ASP A 231
 None
 0.89A 1rg9A-3blwA:
undetectable		 1rg9A-3blwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 166
ASP A 208
ILE A 209
ASP A 231
 None
 0.88A 1rg9D-3blwA:
undetectable		 1rg9D-3blwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 VAL A  36
THR A  38
ILE A 319
ALA A 314
PRO A 288
 None
 1.18A 2admB-3blwA:
undetectable		 2admB-3blwA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 274
PHE A 230
ALA A 108
ILE A 214
THR A 235
 FLC  A1001 (-3.4A)
None
None
None
None
 1.13A 2bjfA-3blwA:
undetectable		 2bjfA-3blwA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 THR A 235
VAL A 181
ASN A 218
ALA A 223
 None
 0.78A 2ij7C-3blwA:
undetectable		 2ij7C-3blwA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 299
ASN A 300
LEU A 302
GLY A 303
THR A 309
 None
 1.05A 2q7lA-3blwA:
undetectable		 2q7lA-3blwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 257
GLY A 253
ALA A 249
LEU A 250
 None
 0.82A 2wekB-3blwA:
undetectable		 2wekB-3blwA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 125
SER A 177
THR A 179
VAL A 181
 None
 0.87A 3d2tA-3blwA:
undetectable		 3d2tA-3blwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 236
SER A 237
GLY A 190
MET A 154
 None
 1.07A 3hcnA-3blwA:
undetectable		 3hcnA-3blwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 162
PHE A 165
ALA A 166
ILE A 126
GLY A 259
 None
 0.79A 3nxuA-3blwA:
undetectable		 3nxuA-3blwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 169
LEU A 297
GLY A 259
ILE A 128
 None
 0.76A 3wrkA-3blwA:
undetectable		 3wrkA-3blwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 123
PHE A 110
LEU A 250
VAL A 127
LEU A 125
 None
 1.25A 4g1bC-3blwA:
2.3		 4g1bC-3blwA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 198
ALA A 180
VAL A 181
ALA A 166
 None
 0.79A 4g77A-3blwA:
undetectable		 4g77A-3blwA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 125
THR A 235
THR A 179
VAL A 181
 None
 0.76A 4ik7A-3blwA:
undetectable		 4ik7A-3blwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 125
THR A 235
THR A 179
VAL A 181
 None
 0.69A 4ik7B-3blwA:
undetectable		 4ik7B-3blwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 166
ASP A 208
ILE A 209
ASP A 231
 None
 0.88A 4kttB-3blwA:
undetectable		 4kttB-3blwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 THR A 179
LEU A 233
THR A 241
MET A 238
 None
None
FLC  A1001 (-2.6A)
None
 1.49A 4mbsB-3blwA:
undetectable		 4mbsB-3blwA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 125
THR A 235
SER A 177
THR A 179
 None
 0.61A 4pwjB-3blwA:
undetectable		 4pwjB-3blwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 255
THR A 289
ILE A 329
PHE A 110
ILE A 251
 AMP  A2001 ( 4.2A)
None
None
None
None
 1.27A 4zvmA-3blwA:
2.2
4zvmB-3blwA:
3.0		 4zvmA-3blwA:
20.27
4zvmB-3blwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 125
THR A 235
SER A 177
THR A 179
 None
 0.79A 5bojB-3blwA:
undetectable		 5bojB-3blwA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 217
VAL A 181
LEU A 243
 None
 0.62A 5e5jB-3blwA:
undetectable		 5e5jB-3blwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 186
MET A 238
ASP A 217
 None
 0.78A 5h2uA-3blwA:
undetectable		 5h2uA-3blwA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 168
ILE A 162
ARG A 161
TYR A 104
 None
 1.48A 5igyA-3blwA:
undetectable		 5igyA-3blwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 169
LEU A 297
GLY A 259
ILE A 128
 None
 0.77A 5ik1A-3blwA:
undetectable		 5ik1A-3blwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  37
PRO A  24
ASN A  53
 None
 1.05A 5jwaA-3blwA:
2.6
5jwaH-3blwA:
undetectable		 5jwaA-3blwA:
21.01
5jwaH-3blwA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 280
PRO A 271
GLU A 270
ARG A 327
GLU A  31
 None
 1.41A 5mqtC-3blwA:
1.1		 5mqtC-3blwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 162
PHE A 165
ALA A 166
ILE A 126
ALA A 108
 None
 1.19A 5vc0A-3blwA:
undetectable		 5vc0A-3blwA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3blw ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 274
PHE A 136
ARG A 129
 FLC  A1001 (-3.4A)
FLC  A1001 (-4.5A)
FLC  A1001 (-3.4A)
 1.11A 5y9yA-3blwA:
undetectable		 5y9yA-3blwA:
20.32